Impact exercise strategies in the HRQOL of the sedentary adults

El objetivo del estudio fue analizar la eficacia de diferentes estrategias de intervención del ejercicio físico y relacionarlas con la percepción de la calidad de vida relacionada con la salud (CVRS) en adultos mayores sedentarios. Participaron 100 sujetos, con edades comprendidas entre los 60 y 70 años, que fueron divididos aleatoriamente en cuatro grupos: control, recomendación, prescripción y monitorización. La intervención de ejercicio físico tuvo una duración de 6 meses. Para la valoración de la CVRS se utilizó el cuestionario SF-36. Los grupos monitorización y prescripción obtuvieron los mayores valores en todos los dominios en el análisis intragrupos. La función física y la salud general y mental obtienen los mayores valores significativos entre grupos (p<.05). Entre los grupos prescripción y monitorización no existen diferencias significativas en ninguna dimensión. Sin embargo el grupo de monitorización obtuvo valores superiores en salud mental, no siendo así en salud físicaThe aim of the study was to analyze the effectiveness of different intervention strategies of exercise and relate the perception of quality of life related to health (HRQOL) in sedentary older adults. It involved 100 subjects, aged between 60 and 70, who were randomly divided into four groups: control, recommend, prescribe and monitor. The exercise intervention lasted 6 months. The SF-36 questionnaire was used for the assessment of HRQOL. The monitoring and prescription groups had higher values in all domains in the intragroup analysis. Physical function and health and mental health obtain the highest significant values between groups (p <.05). There are no significant differences at all in any domain among prescription and monitoring groups. However, the monitoring group obtained higher values in mental health, but were not in physical healt

Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%

Nuclear modification factor of D0 mesons in PbPb collisions at sNN=5.02TeV

The transverse momentum (pT) spectrum of prompt D0 mesons and their antiparticles has been measured via the hadronic decay channels D0→K−π+ and D‾0→K+π− in pp and PbPb collisions at a centre-of-mass energy of 5.02 TeV per nucleon pair with the CMS detector at the LHC. The measurement is performed in the D0 meson pT range of 2–100GeV/c and in the rapidity range of |y|<1. The pp (PbPb) dataset used for this analysis corresponds to an integrated luminosity of 27.4 pb−1 (530 μb−1). The measured D0 meson pT spectrum in pp collisions is well described by perturbative QCD calculations. The nuclear modification factor, comparing D0 meson yields in PbPb and pp collisions, was extracted for both minimum-bias and the 10% most central PbPb interactions. For central events, the D0 meson yield in the PbPb collisions is suppressed by a factor of 5–6 compared to the pp reference in the pT range of 6–10GeV/c. For D0 mesons in the high-pT range of 60–100GeV/c, a significantly smaller suppression is observed. The results are also compared to theoretical calculations

Search for single production of a vector-like T quark decaying to a Z boson and a top quark in proton–proton collisions at √s = 13 TeV

A search is presented for single production of a vector-like quark (T) decaying to a Z boson and a top quark, with the Z boson decaying leptonically and the top quark decaying hadronically. The search uses data collected by the CMS experiment in proton–proton collisions at a center-of-mass energy of 13 TeV in 2016, corresponding to an integrated luminosity of 35.9 fb⁻¹. The presence of forward jets is a particular characteristic of single production of vector-like quarks that is used in the analysis. For the first time, different T quark width hypotheses are studied, from negligibly small to 30% of the new particle mass. At the 95% confidence level, the product of cross section and branching fraction is excluded above values in the range 0.26–0.04 pb for T quark masses in the range 0.7–1.7 TeV, assuming a negligible width. A similar sensitivity is observed for widths of up to 30% of the T quark mass. The production of a heavy Z′ boson decaying to Tt, with T→tZ, is also searched for, and limits on the product of cross section and branching fractions for this process are set between 0.13 and 0.06 pb for Z′ boson masses in the range from 1.5 to 2.5 TeV

Search for Higgs boson pair production in events with two bottom quarks and two tau leptons in proton–proton collisions at √s =13 TeV

A search for the production of Higgs boson pairs in proton–proton collisions at a centre-of-mass energy of 13 TeV is presented, using a data sample corresponding to an integrated luminosity of 35.9 fb$^{-1}$ collected with the CMS detector at the LHC. Events with one Higgs boson decaying into two bottom quarks and the other decaying into two τ leptons are explored to investigate both resonant and nonresonant production mechanisms. The data are found to be consistent, within uncertainties, with the standard model background predictions. For resonant production, upper limits at the 95% confidence level are set on the production cross section for Higgs boson pairs as a function of the hypothesized resonance mass and are interpreted in the context of the minimal supersymmetric standard model. For nonresonant production, upper limits on the production cross section constrain the parameter space for anomalous Higgs boson couplings. The observed (expected) upper limit at 95% confidence level corresponds to about 30 (25) times the prediction of the standard model

Cognitive features of schizotypal personality

El presente trabajo estudia la relación entre personalidad esquizotípica e indicadores neuropsicológicos de alto-riesgo de esquizofrenia. La muestra inicial la formaron 726 sujetos (14-20 años) los cuáles fueron divididos en dos grupos según su nivel de esquizotipia (Multidimensional Schizotypal Traits Questionnaire; MSTQ). Como criterios de agrupamiento se tomaron los puntos de corte correspondientes o los centiles 15-85 y 5-95 en MSTQ. Se computaron los errores en varias tareas cognítivas (Category Test, CAT; Test de Reconocimiento de Palabras, TRP; Prueba Visual de Memoria Operativa, PVMO-1 y Prueba Verbal de Memoria Operativa, PVMO-2) con el fin de comparar ambos grupos. Pero el primer punto de corte (15%), de las comparaciones realizadas entre ambos grupos (esquizotípicos-no esquizotípicos) no se obtuvieron diferencias significativas pero ninguna de las tareas. Paro el segundo punto de corte (5%), se constataron diferencias significativas en dos de las tareas (TRP y PVM0-1)

Study protocol for a randomized clinical trial to assess 7 versus 14-days of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial)

Background Research priorities in Antimicrobial Stewardship (AMS) have rapidly evolved in the last decade. The need for a more efficient use of antimicrobials have fueled plenty of studies to define the optimal duration for antibiotic treatments, and yet, there still are large areas of uncertainty in common clinical scenarios. Pseudomonas aeruginosa has been pointed as a priority for clinical research, but it has been unattended by most randomized trials tackling the effectiveness of short treatments. The study protocol of the SHORTEN-2 trial is presented as a practical example of new ways to approach common obstacles for clinical research in AMS. Objective To determine whether a 7-day course of antibiotics is superior to 14-day schemes for treating bloodstream infections by P. aeruginosa (BSI-PA). Methods A superiority, open-label, randomized controlled trial will be performed across 30 Spanish hospitals. Adult patients with uncomplicated BSI-PA will be randomized to receive a 7 versus 14-day course of any active antibiotic. The primary endpoint will be the probability for the 7-day group of achieving better outcomes than the control group, assessing altogether clinical effectiveness, severe adverse events, and antibiotic exposure through a DOOR/RADAR analysis. Main secondary endpoints include treatment failure, BSI-PA relapses, and mortality. A superiority design was set for the primary endpoint and non-inferiority for treatment failure, resulting in a sample size of 304 patients. Conclusions SHORTEN-2 trial aligns with some of the priorities for clinical research in AMS. The implementation of several methodological innovations allowed overcoming common obstacles, like feasible sample sizes or measuring the clinical impact and unintended effects

Snowmass Neutrino Frontier: DUNE Physics Summary

The Deep Underground Neutrino Experiment (DUNE) is a next-generation long-baseline neutrino oscillation experiment with a primary physics goal of observing neutrino and antineutrino oscillation patterns to precisely measure the parameters governing long-baseline neutrino oscillation in a single experiment, and to test the three-flavor paradigm. DUNE's design has been developed by a large, international collaboration of scientists and engineers to have unique capability to measure neutrino oscillation as a function of energy in a broadband beam, to resolve degeneracy among oscillation parameters, and to control systematic uncertainty using the exquisite imaging capability of massive LArTPC far detector modules and an argon-based near detector. DUNE's neutrino oscillation measurements will unambiguously resolve the neutrino mass ordering and provide the sensitivity to discover CP violation in neutrinos for a wide range of possible values of $\delta_{CP}$. DUNE is also uniquely sensitive to electron neutrinos from a galactic supernova burst, and to a broad range of physics beyond the Standard Model (BSM), including nucleon decays. DUNE is anticipated to begin collecting physics data with Phase I, an initial experiment configuration consisting of two far detector modules and a minimal suite of near detector components, with a 1.2 MW proton beam. To realize its extensive, world-leading physics potential requires the full scope of DUNE be completed in Phase II. The three Phase II upgrades are all necessary to achieve DUNE's physics goals: (1) addition of far detector modules three and four for a total FD fiducial mass of at least 40 kt, (2) upgrade of the proton beam power from 1.2 MW to 2.4 MW, and (3) replacement of the near detector's temporary muon spectrometer with a magnetized, high-pressure gaseous argon TPC and calorimeter