A New Frequency Planning for Improved Capacity and Coverage in Sectorized OFDMA Cellular Networks

One of the main challenges in cellular systems is how to reduce Other Cells Interference (OCI) while keeping high spectral efficiency and high coverage probability. Since the beginning of cellular technologies, frequency planning with sectoring has been used to mitigate such OCI. However, in modern wireless Orthogonal Frequency Division Multiple Access (OFDMA) technologies much attention is being paid to more complex strategies like Coordintation Multi-Point transmission/reception (CoMP) techniques due to its higher performance. This paper presents a new frequency planning for sectorized cell networks. Simulation results show that this scheme considerably outperforms classical sectoring (CS) in terms of both capacity and coverage probability. In particular, for the case of hexagonal grid, the capacity improvement is around 6 b/s/Hz compared to CS while keeping a coverage probability higher than 0.9 for a 0 dB Signal to Interference plus Noise Ratio (SINR) threshold.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

A New Tractable Model to Estimate the Uplink Inter-Cell Interference in LTE

This paper presents a tractable model to estimate the uplink Inter-Cell Interference (ICI) in fully loaded LTE networks. Interfering users are considered to be uniformly distributed in an annulus so that evaluation of the interference power is obtained asymptotically for a high number of users. Model validity is proved through Monte Carlo simulations, showing that analytical results are close to simulation results even for a low number of users per cell.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Coordinated Multicast/Unicast Transmission on 5G: A Novel Approach for Linear Broadcasting

Linear broadcasting services, with a scheduled programming, constitute a paramount tel-ecommunication service for today’s society. Although the existing technology is mature, current linear broadcast systems have serious limitations when providing service to moving users or users placed in areas with complex orography and poor signal quality. To over-come these limitations, 3GPP 5G standard has included a work item to support 5G mul-ticast/broadcast services for future Release 17. This paper investigates the integration of point-to-point (unicast) communication with cellular multicast/broadcast on 5G technology to extend the current support of linear broadcasting services. This integration relies on the use mobile edge computing (MEC) at the 5G base station (gNB) to host a dynamic adap-tive streaming over HTTP (DASH) server that is coordinated with the multicast transmis-sion to complement the broadcast service. This approach join the reliability of point-to-point communications, with dedicated resources for each user, with the spectrum efficiency of multi-cast communications, where a set of users share common resources. The coopera-tion between those unicast and multicast schemes allows those users whose coverage is not good enough, to complete the linear broadcast flow through the point-to-point transmission via MEC. The benefits of such approach have been assessed with simulations in a realistic scenario that considers a vehicle moving across a sparsely populated region in southern Spain. Results reveals that throughput and bitrate playback (reproduction rate) are greatly improved when unicast/multicast integration is enabled since the number of stalling events is reduced significantly.This work has been partially supported by Radio Televisión Española through Impulsa Visión RTVE grant and by the Universidad de Málaga. We are grateful to Pere Vila, Esteban Mayoral Campos, Adolfo Muñoz Berrón and Miguel Ángel Bona San Vicente for their support and collaboration during the development of the project. Funding for open access charge: Universidad de Málaga / CBU

Joint Distribution of Distance and Angles in Finite Wireless Networks

Directional beamforming will play a paramount role in 5G and beyond networks in order to combat the higher path losses incurred at millimeter wave bands. Appropriate modeling and analysis of the angles and distances between transmitters and receivers in these networks are thus essential to understand performance and limiting factors. Most existing literature considers either infinite and uniform networks, where nodes are drawn according to a Poisson point process, or finite networks with the reference receiver placed at the origin of a disk. Under either of these assumptions, the distance and azimuth angle between transmitter and receiver are independent, and the angle follows a uniform distribution between $0$ and $2\pi$. Here, we consider a more realistic case of finite networks where the reference node is placed at any arbitrary location. We obtain the joint distribution between the distance and azimuth angle and demonstrate that these random variables do exhibit certain correlation, which depends on the shape of the region and the location of the reference node. To conduct the analysis, we present a general mathematical framework which is specialized to exemplify the case of a rectangular region. We then also derive the statistics for the 3D case where, considering antenna heights, the joint distribution of distance, azimuth and zenith angles is obtained. Finally, we describe some immediate applications of the present work, including the analysis of directional beamforming, the design of analog codebooks and wireless routing algorithms.Comment: 14 pages, 14 figure

Selección Dinámica de Celda en los Enlaces Ascendente y Descendente de Redes Heterogéneas: Estudio de las Estratégias Acoplada y Desacoplada

Dynamic cell selection (DCS) and decoupled access are two disruptive candidate schemes for cell association in future 5G networks. DCS provides adaptation to fast channel variations, which results in potential performance enhancement. On the other hand, decoupled accesses cope with the difference between uplink and downlink transmissions aiming to maximize their performance. In this paper, we investigate the performance such access schemes for both the downlink and the uplink with fractional power control (FPC) and compare them with different combinations of their static and coupled counter parts. Results reveal that decoupled access yields to a great fairness degree in the uplink, while the cost to pay is a minor reduction on the average rate. Additionally, dynamic cell selection with decoupled access leads to a high improvement of both fairness and average rate in the downlink and uplink.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Prestaciones de LTE sobre el canal aeronáutico

This work assesses the performance of Long Term Evolution (LTE) downlink over aeronautical channels associated to arrival, parking and en-route scenarios. The huge velocity related to some of these scenarios poses the following challenges: (1) (Inter-Carrier-Interference) ICI due to Doppler Shift, (2) ICI due to Doppler spread and (3) channel estimation errors. Taking into account these problems a physical layer LTE modem has been implemented. Results reveals that LTE can achive good performance in air-to-ground communications with aircraft moving at 1500 km/h without a complex receiver.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition

Wheat gluten proteins are responsible for the bread-making properties of the dough but also for triggering important gastrointestinal disorders. Celiac disease (CD) affects approximately 1% of the population in Western countries. The only treatment available is the strict avoidance of gluten in the diet. Interference RNA (RNAi) is an excellent approach for the down-regulation of genes coding for immunogenic proteins related to celiac disease, providing an alternative for the development of cereals suitable for CD patients. In the present work, we report a comparative study of the stimulatory capacity of seven low-gluten RNAi lines differing in grain gluten and non-gluten protein composition, relevant for CD and other gluten pathologies. Peripheral blood mononuclear cells (PBMCs) of 35 patients with active CD were included in this study to assess the stimulatory response induced by protein extracts from the RNAi lines. Analysis of the proliferative response and interferon-gamma (INF-γ) release of PBMCs demonstrated impaired stimulation in response to all RNAi lines. The lower response was provided by lines with a very low content of α- and γ-gliadins, and low or almost devoid of DQ2.5 and p31–43 α-gliadin epitopes. The non-gluten protein seems not to play a key role in PBMC stimulation.Spanish Ministry of Economy, Industry and competitiveness AGL2016-80566-PEuropean Regional Development Fund (FEDER

Negatively charged amino acids at the foot-and-mouth disease virus capsid reduce the virion-destabilizing effect of viral RNA at acidic pH

Elucidation of the molecular basis of the stability of foot-and-mouth disease virus (FMDV) particles is relevant to understand key aspects of the virus cycle. Residue N17D in VP1, located at the capsid inner surface, modulates the resistance of FMDV virion to dissociation and inactivation at acidic pH. Here we have studied whether the virion-stabilizing effect of amino acid substitution VP1 N17D may be mediated by the alteration of electrostatic charge at this position and/or the presence of the viral RNA. Substitutions that either introduced a positive charge (R,K) or preserved neutrality (A) at position VP1 17 led to increased sensitivity of virions to inactivation at acidic pH, while replacement by negatively charged residues (D,E) increased the resistance of virions to acidic pH. The role in virion stability of viral RNA was addressed using FMDV empty capsids that have a virtually unchanged structure compared to the capsid in the RNA-filled virion, but that are considerably more resistant to acidic pH than WT virions, supporting a virion-destabilizing effect of the RNA. Remarkably, no differences were observed in the resistance to dissociation at acidic pH between the WT empty capsids and those harboring replacement N17D. Thus, the virion-destabilizing effect of viral RNA at acidic pH can be partially restored by introducing negatively charged residues at position VP1 N17Work in F.S´s laboratory was funded by grants from MINECO-FEDER EU (AGL2017–84097-C2–1-R), Comunidad de Madrid co-fnanced with ECFEDER funds (P2018/BAA-4370). Work in M.G.M.´s laboratory was funded by grants from MINECO-FEDER EU (BIO2015–69928-R and RTI2018–096635-B-I00). Work by both groups was also funded by an institutional grant from Fundación Ramón Areces M.G.M. is an associate member of the Institute for Biocomputation and Physics of Complex Systems, Zaragoza, Spai

Neurocognitive Function in Acromegaly after Surgical Resection of GH-Secreting Adenoma versus Naïve Acromegaly

Patients with active untreated acromegaly show mild to moderate neurocognitive disorders that are associated to chronic exposure to growth hormone (GH) and insulin-like growth factor (IGF-I) hypersecretion. However, it is unknown whether these disorders improve after controlling GH/IGF-I hypersecretion. The aim of this study was to compare neurocognitive functions of patients who successfully underwent GH-secreting adenoma transsphenoidal surgery (cured patients) with patients with naive acromegaly. In addition, we wanted to determine the impact of different clinical and biochemical variables on neurocognitive status in patients with active disease and after long-term cure. A battery of six standardized neuropsychological tests assessed attention, memory and executive functioning. In addition, a quantitative electroencephalography with Low-Resolution Electromagnetic Tomography (LORETA) solution was performed to obtain information about the neurophysiological state of the patients. Neurocognitive data was compared to that of a healthy control group. Multiple linear regression analysis was also conducted using clinical and hormonal parameters to obtain a set of independent predictors of neurocognitive state before and after cure. Both groups of patients scored significantly poorer than the healthy controls on memory tests, especially those assessing visual and verbal recall. Patients with cured acromegaly did not obtain better cognitive measures than naïve patients. Furthermore memory deficits were associated with decreased beta activity in left medial temporal cortex in both groups of patients. Regression analysis showed longer duration of untreated acromegaly was associated with more severe neurocognitive complications, regardless of the diagnostic group, whereas GH levels at the time of assessment was related to neurocognitive outcome only in naïve patients. Longer duration of post-operative biochemical remission of acromegaly was associated with better neurocognitive state. Overall, this data suggests that the effects of chronic exposure to GH/IGF-I hypersecretion could have long-term effects on brain functions. © 2013 Martín-Rodríguez et al.Funding for this project was provided by an R&D grant from Novartis Oncology and the Plan Andaluz de Investigación (CTS-444). DAC was supported by the “Ramón y Cajal” program (RYC-2006-001071) of the Spanish Ministry of Science and Innovation.Peer Reviewe

Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease

A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease (CD). Traditionally, treatment with a GFD has excluded wheat, barley and rye, while the presence of oats is a subject of debate. The most-recent research indicates that some cultivars of oats can be a safe part of a GFD. In order to elucidate the toxicity of the prolamins from oat varieties with low, medium, and high CD toxicity, the avenin genes of these varieties were cloned and sequenced, and their expression quantified throughout the grain development. At the protein level, we have accomplished an exhaustive characterization and quantification of avenins by RP-HPLC and an analysis of immunogenicity of peptides present in prolamins of different oat cultivars. Avenin sequences were classified into three different groups, which have homology with S-rich prolamins of Triticeae. Avenin proteins presented a lower proline content than that of wheat gliadin; this may contribute to the low toxicity shown by oat avenins. The expression of avenin genes throughout the development stages has shown a pattern similar to that of prolamins of wheat and barley. RP-HPLC chromatograms showed protein peaks in the alcohol-soluble and reduced-soluble fractions. Therefore, oat grains had both monomeric and polymeric avenins, termed in this paper gliadin- and glutenin-like avenins. We found a direct correlation between the immunogenicity of the different oat varieties and the presence of the specific peptides with a higher/lower potential immunotoxicity. The specific peptides from the oat variety with the highest toxicity have shown a higher potential immunotoxicity. These results suggest that there is wide range of variation of potential immunotoxicity of oat cultivars that could be due to differences in the degree of immunogenicity in their sequences