Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia

TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology titled, "ZBTB16-RARA variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature" [1]. We would like to add some comments to their article and suggest additional molecular methods to confirm variant translocations in acute promyelocytic leukemia (APL)...

Experiences with an Online Mobile Learning Platform. Intervention for marginalised young people

Marginalised young people who find themselves disadvantaged in a number of respects also tend to experience limited access to Information and Communication Technologies (ICT) – with the exception of mobile phones. The European Commission-funded ComeIn project seeks to take advantage of marginalised young people’s access to mobile phones by reaching out to them via an innovative pedagogical approach based on the media convergence of the mobile phone through an online platform with video streaming. The platform was developed specifically for the purposes of the project to create the possibility for new, positive learning experiences as well as for interaction with peers and youth workers. In a three-month study in Austria and the United Kingdom, 94 young people accessed the platform via their mobile phones. In this paper we discuss the appropriateness of media convergence as a means for learning in and across three dimensions: interaction, creative expression and self-organisation. Furthermore, we explore how to incorporate initiatives such as ComeIn in an institutionalised context

Konzentration aufs Ziel : genetische Veränderungen setzen bei der Leukämie das Verhältnis von Rot und Weiß außer Kraft

Blut steht für Leben - und für den Tod. Das ist in der Medizin nicht anders als in der Mythologie. Vor wenigen Jahrzehnten war die Diagnose Blutkrebs noch ein sicheres Todesurteil. Heute werden viele Leukämiekranke geheilt. An der Goethe-Universität setzt ein Schwerpunkt für Lymphom- und Leukämieforschung deutschlandweit Akzente bei Forschung und Diagnostik

The future of UK Antarctic science: strategic priorities essential needs and opportunities for international leadership

• The Antarctic region has been experiencing rapid change in recent decades due to human induced factors. Most notably, climate heating is causing ice sheet melting, leading to sea level rise and disruption in global ocean heat circulation, with far-reaching global consequences. • At the same time, this region holds unique research potential that can help address a range of critically important scientific priorities, including climate change impacts, ecosystem protection, the likelihood of extra-terrestrial life and monitoring of space debris. • Due to its long and impressive record of Antarctic research and its scientific, engineering and logistical capabilities in the region, the United Kingdom (UK) is strategically well-positioned to lead or play a key role in the delivery of these research priorities. • To achieve this potential, the UK must act collectively and in partnership with others, as the best and most urgent research benefits from collaboration, cooperation and cost sharing. Crucially, it must mobilise experts both from within the UK and internationally from a range of disciplines, including the social sciences. In the twenty-first century, Antarctic research must not exist within its own bubbl

Tolerância de genótipos de arroz irrigado (Oryza sativa) ao estresse por calor na antese

Global warming is occurring all over the world and climate changes are likely to affect agriculture by raising the frequency of weather events with very high and very low temperatures, which will increase the risks for food production. This study aimed to evaluate the effect of heat stress at anthesis on the agronomic performance of modern Brazilian lowland rice genotypes. The varieties SCS124 Sardo, SCS122 Miura, SCS121 CL, SCS116 Satoru, SCSBRS Tio Taka, Epagri 109 and the inbreeds SC 491 ME, SC 676, SC 792, SC 806, SC 817, SC 849 were tested. At anthesis, plants which received heat stress treatment were transferred to a growth chamber for four days at temperatures of 38ºC (day) and 30ºC (night). After that, they were returned to a greenhouse, remaining there until harvest, under temperatures of about 25ºC. Spikelet sterility ranged from 4.0 to 84.1%. Yield varied from 10.2 to 101.2g pl-1. Heat stress increased spikelet sterility and decreased grain production. The inbreeds SC 817 and SC 806 showed the lowest percentage of spikelet sterility and the highest yield under thermic stress and are thus promising genotypes to generate tolerant cultivars to high temperatures at anthesis.O objetivo deste trabalho foi avaliar o efeito do estresse térmico (calor) na antese sobre o desempenho agronômico de genótipos brasileiros modernos de arroz irrigado. As variedades SCS124 Sardo, SCS122 Miura, SCS121 CL, SCS116 Satoru, SCSBRS Tio Taka, Epagri 109 e as linhagens SC 491 ME, SC 676, SC 792, SC 806, SC 817, SC 849 foram avaliadas. Na antese, as plantas correspondentes ao tratamento de estresse por calor foram transferidas para uma câmara de crescimento por quatro dias sob temperaturas de 38ºC (dia) e 30ºC (noite). Em seguida, voltaram à casa de vegetação, onde permaneceram até a colheita sob 25ºC aproximadamente. A esterilidade de espiguetas variou de 4,0 a 84,1%. A produtividade variou de 10,2 a 101,2g pl-1. O estresse térmico aumentou a esterilidade das espiguetas e diminuiu a produção de grãos. As linhagens SC 817 e 806 apresentaram menor porcentagem de esterilidade de espiguetas e maior produção sob estresse de calor, sendo, portanto, genótipos promissores para gerar cultivares tolerantes a altas temperaturas na antese

Exploring Controls on the Flow Dynamics of Devon Ice Cap using a Basal Friction Inversion

Accurately predicting the future dynamic contribution to mass loss from the ice caps of the High Arctic requires an improved understanding of the basal conditions of these ice bodies. An adjoint method numerical inversion is therefore applied to elucidate the basal and englacial conditions of Devon Ice Cap in the Canadian Arctic Archipelago, which exhibits a variety of changes to flow dynamics in recent years. These include the surge of Southeast1 and Southeast2 Glaciers, which is suggested to be thermally-regulated. A cryo-hydraulic warming feedback may contribute to the acceleration during this surge as an additional source of heat or water is required for the base of sliding areas to reach pressure melting point. During the active phase of the surge, freezing rates increase as the basal temperature gradient increases dramatically, leading to enhanced conductive heat loss which is not countered by additional frictional heating as the weakened till provides less resistance to flow. The termination of this surge could therefore result from water withdrawal from the underlying till without the need for changes to geometry. Glaciers defined as pulsing consistently had lower basal shear stresses when velocities were higher, but different pulses produced different changes to the basal conditions, making it difficult to suggest a mechanism for these events. The cause of the unequal periods of faster and slower flow observed on the Croker Bay Glaciers also remains uncertain. However, changes to water storage in the till layer are far smaller than interannual variability in surface meltwater reaching the bed, suggesting this could play some role in modulating till strength, thus flow speeds. The bed of Belcher Glacier provides very little resistance to flow near the terminus, supporting the hypothesis that its acceleration is a result of the thinning and retreat of the terminus reducing resistive stresses