Scottish bishops and the relic-lists of the cartulary of Christchurch Priory, Twynham, Hampshire, 1200–1221 (with an edition and translation of the text by John Reuben Davies)

No abstract available

'All this I say against the rage of archdeacons against my poor fellow citizens': archdeacons' authority and identity in twelfth-century England

No abstract available

The bishops of King Stephen's reign

Traditionally, the bishops who held office during the civil war which dominated King Stephen's reign (1135-1154) have been considered weak and ineffective, able neither to bring peace between the two sides or among warring local barons nor to protect their flocks or even themselves from the so-called 'Anarchy'. The explanation for this has been found in the bishops' lack of spiritual calibre. Bishops have also been seen as withdrawing their support from the king and ending their involvement in royal government, partly because of increasing general ecclesiastical desire for separation between Church and State and partly because of specific disputes with Stephen. As a consequence of all this, bishops are allowed little importance in modern histories of Stephen's reign. This thesis shows that modern historiographical consensus is based in flawed interpretive frameworks which have led to misinterpretation of the nature of the episcopate and its importance in Stephen's reign. It offers more valid alternatives and then re-examines, the royal, ecclesiastical and, especially, the local evidence in light of them to show that, in fact, the bishops were crucially important figures in regional politics, religion and society during the civil war. It proves as well, that they could possess considerable spiritual authority and continued to be committed to the king and active in the government of the kingdom throughout the period. Additionally, each of these also has consequences for how the episcopacy and Anglo-Norman history in general are understood. This is, therefore, a reassessment of the bishops of King Stephen's reign

Concentrating Membrane Proteins Using Asymmetric Traps and AC Electric Fields

Membrane proteins are key components of the plasma membrane and are responsible for control of chemical ionic gradients, metabolite and nutrient transfer, and signal transduction between the interior of cells and the external environment. Of the genes in the human genome, 30% code for membrane proteins (Krogh et al. J. Mol. Biol.2001, 305, 567). Furthermore, many FDA-approved drugs target such proteins (Overington et al. Nat. Rev. Drug Discovery2006, 5, 993). However, the structure-function relationships of these are notably sparse because of difficulties in their purification and handling outside of their membranous environment. Methods that permit the manipulation of membrane components while they are still in the membrane would find widespread application in separation, purification, and eventual structure-function determination of these species (Poo et al. Nature1977, 265, 602). Here we show that asymmetrically patterned supported lipid bilayers in combination with AC electric fields can lead to efficient manipulation of charged components. We demonstrate the concentration and trapping of such components through the use of a “nested trap” and show that this method is capable of yielding an approximately 30-fold increase in the average protein concentration. Upon removal of the field, the material remains trapped for several hours as a result of topographically restricted diffusion. Our results indicate that this method can be used for concentrating and trapping charged membrane components while they are still within their membranous environment. We anticipate that our approach could find widespread application in the manipulation and study of membrane proteins

Alice Taylor: The Shape of the State in Medieval Scotland 1124-1290

No abstract available

R. H. Darwall-Smith (ed.): Early Records of University College, Oxford

No abstract available

N. Shead (ed.): Scottish Episcopal Acta

No abstract available

Elizabeth van Houts (ed): Anglo-Norman Studies 37 (2015)

No abstract available