The Effect of Waste Loading and Glass Structural Factors on Structure and Chemical Durability of SB2 and SB4 SRS Waste Glasses -11397

ABSTRACT Glassy materials simulating vitrified high-Na/Fe (Sludge Batch 2 -SB2) and high-Na/Fe/Al (Sludge Batch 4 -SB4) Savannah River Site high level wastes (HLW) were produced in a resistive furnace and 236 and 418 mm inner diameter cold crucibles. The effect of waste loading (WL) and glass structural factors (degree of connectedness of glass network, metal oxides to boron oxide ratios) on chemical durability of glassy materials was studied

Galaxy correlations and the BAO in a void universe: structure formation as a test of the Copernican Principle

A suggested solution to the dark energy problem is the void model, where accelerated expansion is replaced by Hubble-scale inhomogeneity. In these models, density perturbations grow on a radially inhomogeneous background. This large scale inhomogeneity distorts the spherical Baryon Acoustic Oscillation feature into an ellipsoid which implies that the bump in the galaxy correlation function occurs at different scales in the radial and transverse correlation functions. We compute these for the first time, under the approximation that curvature gradients do not couple the scalar modes to vector and tensor modes. The radial and transverse correlation functions are very different from those of the concordance model, even when the models have the same average BAO scale. This implies that if void models are fine-tuned to satisfy average BAO data, there is enough extra information in the correlation functions to distinguish a void model from the concordance model. We expect these new features to remain when the full perturbation equations are solved, which means that the radial and transverse galaxy correlation functions can be used as a powerful test of the Copernican Principle.Comment: 12 pages, 8 figures, matches published versio

Thermochemical characterization of polybenzimidazole with and without nano-ZrO2 for ablative materials application

During the ballistic atmospheric re-entry, a space vehicle has to withstand huge thermo-mechanical solicitations because of its high velocity and the friction with the atmosphere. According to the kind of the re-entry mission, the heat fluxes can be very high (in the order of some MW m−2) ;thus, an adequate thermal protection system is mandatory in order to preserve the structure of the vehicle, the payload and, for manned mission, the crew. Carbon phenolic ablators have been chosen for several missions because they are able to dissipate the incident heat flux very efficiently. Phenolic resin presents satisfying performance but also environmental drawbacks. Thus, a more environmental-friendly solution was conceived: a high-performance thermoplastic material, polybenzimidazole (PBI), was employed instead of phenolic resin. In this work PBI-ablative material samples were manufactured with and without the addition of nano-ZrO2 and tested with an oxyacetylene flame. For comparison, some carbon-phenolic ablators with the same density were manufactured and tested too. Thermogravimetric analysis on PBI samples was carried out at different heating rates, and the obtained TG data were elaborated to evaluate the activation energy of PBI and nano-filled PBI. The thermokinetics results for PBI show an improvement in thermal stability due to the addition of nano-ZrO2, while the oxyacetylene flame test enlightens how PBI ablators are able to overcome the carbon phenolic ablators performance, in particular when modified by the addition of nano-ZrO2

Proteomic analysis of apricot fruit during ripening

Ripening of climacteric fruits involves a complex network of biochemical and metabolic changes that make them palatable and rich in nutritional and health-beneficial compounds. Since fruit maturation has a profound impact on human nutrition, it has been recently the object of increasing research activity by holistic approaches, especially on model species. Here we report on the original proteomic characterization of ripening in apricot, a widely cultivated species of temperate zones appreciated for its taste and aromas, whose cultivation is yet hampered by specific limitations. Fruits of Prunus armeniaca cv. Vesuviana were harvested at three ripening stages and proteins extracted and resolved by 1D and 2D electrophoresis. Whole lanes from 1D gels were subjected to shot-gun analysis that identified 245 gene products, showing preliminary qualitative differences between maturation stages. In parallel, differential analysis of 2D proteomic maps highlighted 106 spots as differentially represented among variably ripen fruits. Most of these were further identified by means of MALDI-TOF-PMF and nanoLC–ESI–LIT–MS/MS as enzymes involved in main biochemical processes influencing metabolic/structural changes occurring during maturation, i.e. organic acids, carbohydrates and energy metabolism, ethylene biosynthesis, cell wall restructuring and stress response, or as protein species linkable to peculiar fruit organoleptic characteristics. In addition to originally present preliminary information on the main biochemical changes that characterize apricot ripening, this study also provides indications for future marker-assisted selection breeding programs aimed to ameliorate fruit quality

Multi-risk assessment in a historical city

AbstractNatural hazards pose a significant threat to historical cities which have an authentic and universal value for mankind. This study aims at codifying a multi-risk workflow for seismic and flood hazards, for site-scale applications in historical cities, which provides the Average Annual Loss for buildings within a coherent multi-exposure and multi-vulnerability framework. The proposed methodology includes a multi-risk correlation and joint probability analysis to identify the role of urban development in re-shaping risk components in historical contexts. The workflow is unified by exposure modelling which adopts the same assumptions and parameters. Seismic vulnerability is modelled through an empirical approach by assigning to each building a vulnerability value depending on the European Macroseismic Scale (EMS-98) and modifiers available in literature. Flood vulnerability is modelled by means of stage-damage curves developed for the study area and validated against ex-post damage claims. The method is applied to the city centre of Florence (Italy) listed as UNESCO World Heritage site since 1982. Direct multi-hazard, multi-vulnerability losses are modelled for four probabilistic scenarios. A multi-risk of 3.15 M€/year is estimated for the current situation. In case of adoption of local mitigation measures like floodproofing of basements and installation of steel tie rods, multi-risk reduces to 1.55 M€/yr. The analysis of multi-risk correlation and joint probability distribution shows that the historical evolution of the city centre, from the roman castrum followed by rebuilding in the Middle Ages, the late XIX century and the post WWII, has significantly affected multi-risk in the area. Three identified portions of the study area with a different multi-risk spatial probability distribution highlight that the urban development of the historical city influenced the flood hazard and the seismic vulnerability. The presented multi-risk workflow could be applied to other historical cities and further extended to other natural hazards

Regression spline bivariate probit models: A practical approach to testing for exogeneity

Bivariate probit models can deal with a problem usually known as endogeneity. This issue is likely to arise in observational studies when confounders are unobserved. We are concerned with testing the hypothesis of exogeneity (or absence of endogeneity) when using regression spline recursive and sample selection bivariate probit models. Likelihood ratio and gradient tests are discussed in this context and their empirical properties investigated and compared with those of the Lagrange multiplier and Wald tests through a Monte Carlo study. The tests are illustrated using two datasets in which the hypothesis of exogeneity needs to be tested

Expression of tumor-associated antigens in breast cancer subtypes

OBJECTIVES: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer. MATERIAL AND METHODS: A total of 250 selected invasive breast cancers including 50 estrogen receptor (ER)-positive (Luminal B like), 50 triple-negative (TN), 50 ER-positive lobular type, 50 ER- and progesterone receptor (PgR)-positive (Luminal A like) and 50 cerbB2-positive breast cancers, were assessed for New York esophageal squamous cell carcinoma-1 (NY-ESO-1), Wilms tumor antigen (WT-1) and PReferentially expressed Antigen of MElanoma (PRAME) antigen expression by immunohistochemistry (IHC). RESULTS: A significantly higher expression of cancer testis (CT)-antigens NY-ESO-1 and WT-1 antigen was detected in TN breast cancers compared with ER-positive tumors. NY-ESO-1 overexpression (score 2 + and 3+) assessed by monoclonal and polyclonal antibodies was detected in 9 (18%) TN cancers as compared to 2 (4%) ER-positive tumors (p = 0.002). WT1 over-expression (score 2 + and 3+) was confirmed in 27 (54%) TN tumor samples as compared to 6 (12%) ER-positive (p < 0.0001). PRAME over-expression (score 2 + and 3+) was detected in 8 (16%) HER2 positive tumor samples as compared to no TN and ER-positive cancers (p = 0.0021). CONCLUSIONS: NY-ESO-1 and WT1 antigens are overexpressed in TN breast cancers. Because of the limited therapeutic options for this patient subgroup, CT antigen-based vaccines might prove to be useful for patients with this phenotype of breast cancer

Cosmological background solutions and cosmological backreactions

The cosmological backreaction proposal, which attempts to account for observations without a primary dark energy source in the stress-energy tensor, has been developed and discussed by means of different approaches. Here, we focus on the concept of cosmological background solutions in order to develop a framework to study different backreaction proposals.Comment: 14 pages, 5 figures; major changes, replaced to match the version published in General Relativity and Gravitatio

Observational constraints on inhomogeneous cosmological models without dark energy

It has been proposed that the observed dark energy can be explained away by the effect of large-scale nonlinear inhomogeneities. In the present paper we discuss how observations constrain cosmological models featuring large voids. We start by considering Copernican models, in which the observer is not occupying a special position and homogeneity is preserved on a very large scale. We show how these models, at least in their current realizations, are constrained to give small, but perhaps not negligible in certain contexts, corrections to the cosmological observables. We then examine non-Copernican models, in which the observer is close to the center of a very large void. These models can give large corrections to the observables which mimic an accelerated FLRW model. We carefully discuss the main observables and tests able to exclude them.Comment: 27 pages, 7 figures; invited contribution to CQG special issue "Inhomogeneous Cosmological Models and Averaging in Cosmology". Replaced to match the improved version accepted for publication. Appendix B and references adde