A process development approach to a platformable and robust scale up for enrichment of full AAV capsids using membrane chromatography

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THE CONCEPT OF BODY LANGUAGE IN THE MEDICAL CONSULTATION

In this paper we wish to argue that the human body is an instrument of communication that can be used by the individual. This can be shown by the use of phenomenology, as described by Husserl, and that indeed empathy, as described by phenomenology, can be seen as a link enabling two human bodies/persons to communicate. We then wish to show from neuroscience that empathy can itself be seen as a bodily function. We then will describe how the doctor-patient relationship in the consultation is an extremely important type of communication between two persons, and how teaching of consultation skills has developed. We will show that, once consultation skills teaching was established, then study of body language became an essential part of this teaching, as soon as the technology was developed, and finally we will demonstrate that it is now possible to confirm by observational and controlled trials that appropriate use of body language does indeed enhance the effectiveness of the consultation, including, we would suggest, by appropriate communication of empathy and understanding

THE DOCTOR PATIENT RELATIONSHIP; WHAT IF COMMUNICATION SKILLS ARE NOT USED? A MALTESE STORY

The doctor patient relationship is fundamental to the practice of medicine. In the UK, much work has been carried out to develop taining in communication skills for both doctors and medical students. Whereas it is true that controled trials of communication skills are now beginning to emerge in the primary care literature, it is also true that there is need for studies of communication skills on the hospital ward. One alternative form of evidence for the need of communication skills is that of anthropological studies of hospital wards. We here summarise the observations made in one such anthropological study which was carried out in a renal unit in Malta. The conclusion of these observations is that the inability of the doctors to utilise communication skills is that patients develop meaningful relationships with other groups of professionals, to the extent that they consider them as part of an extended family. Doctors remain isolated from all these relationships and only relate to patients from a position of power

An ngVLA Wide Area AGN Survey

The next generation Very Large Array (ngVLA) will have unprecedented sensitivities and mapping speeds at $1-8$ GHz. We discuss how the active galactic nuclei (AGN) community can benefit from a wide-area, medium depth ngVLA survey. We propose a 10 deg$^2$ survey in the Stripe 82 field using the 8 GHz band with an rms depth of $1\,\mu$Jy beam$^{-1}$. We will detect $\sim$130,000 galaxies, including radio-quiet AGN out to $z\sim7$. We can measure the luminosity and space density evolution of radio-quiet and radio-loud AGN. We can also measure AGN evolution through clustering of both populations using cross-correlation functions. A wide area ngVLA survey will benefit from existing multiwavelength AGN populations, particularly in the Stripe 82 field, as well as new information from next-generation optical and infrared survey instruments such as LSST and WFIRST.Comment: ngVLA Science Use Case to appear in the ngVLA Science Book (http://ngvla.nrao.edu/page/scibook

Selective primary alcohol oxidation of lignin streams from butanol-pretreated agricultural waste biomass

We would like to thank the CRITICAT Centre for Doctoral Training for financial support [Ph.D. studentship to IP; Grant code: EP/L016419/1] and BBSRC Global Challenges Research Fund Impact Acceleration Account at St Andrews BB/GCRFIAA/20. CSL thanks the Leverhulme Trust for funding an Early Career Fellowship.Chemically modified lignins are important for the generation of biomass-derived materials and as precursors to renewable aromatic monomers. A butanol-based organosolv pretreatment has been used to convert an abundant agricultural waste product, rice husks, into a cellulose pulp and three additional product streams. One of these streams, a butanol-modified lignin, was oxidized at the γ position to give a carboxylic acid functionalized material. Subsequent coupling of the acid with aniline aided lignin characterization and served as an example of the flexibility of this approach for grafting side chains onto a lignin core structure. The pretreatment was scaled up for use on a multi-kilogram scale, a development that enabled the isolation of an anomeric mixture of butoxylated xylose in high purity. The robust and scalable butanosolv pretreatment has been developed further and demonstrates considerable potential for the processing of rice husks.PostprintPeer reviewe