Flowchart.

<p>Fig 1 summarizes the selection of the articles included in this literature review.</p

Disability and health-related quality of life features associated with clinically significant symptoms of anxiety and depression in patients with systemic sclerosis.

<p>Values are given in median (interquartile range).</p><p>*After Bonferroni correction for multiple comparisons, a p-value less than 0.001 was considered statistically significant.</p><p>CHFS: Cochin Hand Function Scale; HAQ: Health Assessment Questionnaire; MACTAR: McMaster-Toronto Arthritis Patient Preference Disability Questionnaire; MCS: Mental Component Score; MHISS: Mouth Handicap In Systemic Sclerosis Scale; n: number; PCS: Physical Component Score; SF-36: Medical Outcomes Study 36-Item Short Form Health Survey.</p

Final model of multivariable analysis of current clinically significant symptoms of depression and anxiety according to clinical, functional and health-related quality of life features of patients with systemic sclerosis, with adjustment for age and sex.

<p>A p-value less than 0.05 was considered statistically significant.</p><p>CI: confidence interval; HAQ: Health Assessment Questionnaire; PCS: Physical Component Score;; of SF-36: Medical Outcomes Study 36-Item Short Form Health Survey.</p

Clinical features associated with clinically significant symptoms of anxiety and depression in patients with systemic sclerosis^*.

<p>Values are number/number of patients for whom the data is available (%), otherwise indicated.</p><p>*After Bonferroni correction for multiple comparisons, a p-value less than 0.001 was considered statistically significant.</p><p>IQR: interquartile range; KPS: Karnofsky Performance Status; n: number; NYHA: New York Heart Association; PAP: pulmonary artery pressure; SSc: systemic sclerosis.</p

Demographic and clinical characteristics of 381 patients with systemic sclerosis^*.

<p>*Values are number/number of patients for whom the data is available (%), otherwise indicated.</p><p>IQR: interquartile range; KPS: Karnofsky performance status; NYHA: New York Heart Association; PAP: pulmonary artery pressure.</p