Tumor section (H&E) shows loosely arranged medium-sized cells with finely dispersed chromatin, solitary nucleoli and clear, often vacuolated cytoplasm

<p><b>Copyright information:</b></p><p>Taken from "Midline carcinoma with t(15;19) and fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy"</p><p>BMC Cancer 2006;6():69-69.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1456975.</p><p>Copyright © 2006 Engleson et al; licensee BioMed Central Ltd.</p> The upper left inset depicts PAS-positive cytoplasmic glycogen granules, while the middle inset shows strong epithelial membrane antigen expression in all tumor cells. The lower inset includes the single field which expressed the broad spectrum cytokeratin marker MNF116

CT-scan of upper mediastinum when the tumor progressed after two cycles of VIDE

<p><b>Copyright information:</b></p><p>Taken from "Midline carcinoma with t(15;19) and fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy"</p><p>BMC Cancer 2006;6():69-69.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1456975.</p><p>Copyright © 2006 Engleson et al; licensee BioMed Central Ltd.</p> Tumor masses almost surrounds the superior vena cava (with the stent) and right upper lobe bronchus. At the autopsy four weeks later, there was only a tiny focus of tumor left in conjunction with the cava stent

Fluorecense in situ hybridization: a) Metaphase FISH of the t(15;19) showing one green (15q14) and one red (19p13) signal on the normal homologues

<p><b>Copyright information:</b></p><p>Taken from "Midline carcinoma with t(15;19) and fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy"</p><p>BMC Cancer 2006;6():69-69.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1456975.</p><p>Copyright © 2006 Engleson et al; licensee BioMed Central Ltd.</p> The 15q14- and the 19p13-specific BAC probes were both split by the translocation and therefore visualized as a red-green (yellow) fusion signals on der(15) and der(19), respectively. b) Interphase FISH. Yellow arrows indicate fusions

Additional file 3: Figure S2. of Respiratory chain complex III deficiency due to mutated BCS1L: a novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model

Coronal section at the level of the left amygdala. The bulk of the white matter is reduced and shows discoloration in the temporal lobe. The corpus callosum is thin and there is moderate lateral and third ventricular dilation. Cortical laminar necrosis is seen in the cingulate gyrus, the superior frontal gyrus, the precentral gyrus, the inferior temporal gyrus and the lateral occipitotemporal gyrus (arrows). (PDF 5698 kb