164 research outputs found

    Wigs, disguises and child's play : solidarity in teacher education

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    It is generally acknowledged that much contemporary education takes place within a dominant audit culture, in which accountability becomes a powerful driver of educational practices. In this culture both pupils and teachers risk being configured as a means to an assessment and target-driven end: pupils are schooled within a particular paradigm of education. The article discusses some ethical issues raised by such schooling, particularly the tensions arising for teachers, and by implication, teacher educators who prepare and support teachers for work in situations where vocational aims and beliefs may be in in conflict with instrumentalist aims. The article offers De Certeau’s concept of ‘la perruque’ to suggest an opening to playful engagement for human ends in education, as a way of contending with and managing the tensions generated. I use the concept to recover a concept of solidarity for teacher educators and teachers to enable ethical teaching in difficult times

    The Role of Liver-Directed Surgery in Patients With Hepatic Metastasis From Primary Breast Cancer: a Multi-Institutional Analysis

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    BACKGROUND: Data on surgical management of breast liver metastasis are limited. We sought to determine the safety and long-term outcome of patients undergoing hepatic resection of breast cancer liver metastases (BCLM). METHODS: Using a multi-institutional, international database, 131 patients who underwent surgery for BCLM between 1980 and 2014 were identified. Clinicopathologic and outcome data were collected and analyzed. RESULTS: Median tumor size of the primary breast cancer was 2.5 cm (IQR: 2.0-3.2); 58 (59.8%) patients had primary tumor nodal metastasis. The median time from diagnosis of breast cancer to metastasectomy was 34 months (IQR: 16.8-61.3). The mean size of the largest liver lesion was 3.0 cm (2.0-5.0); half of patients (52.0%) had a solitary metastasis. An R0 resection was achieved in most cases (90.8%). Postoperative morbidity and mortality were 22.8% and 0%, respectively. Median and 3-year overall-survival was 53.4 months and 75.2%, respectively. On multivariable analysis, positive surgical margin (HR 3.57, 95% CI 1.40-9.16; p = 0.008) and diameter of the BCLM (HR 1.03, 95% CI 1.01-1.06; p = 0.002) remained associated with worse OS. DISCUSSION: In selected patients, resection of breast cancer liver metastases can be done safely and a subset of patients may derive a relatively long survival, especially from a margin negative resection.info:eu-repo/semantics/publishedVersio

    The interplay of KRAS mutational status with tumor laterality in non-metastatic colorectal cancer: An international, multi-institutional study in patients with known KRAS, BRAF, and MSI status

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    Background: Although the prognostic relevance of KRAS status in metastatic colorectal cancer (CRC) depends on tumor laterality, this relationship is largely unknown in non-metastatic CRC. Methods: Patients who underwent resection for non-metastatic CRC between 2000 and 2018 were identified from institutional databases at six academic tertiary centers in Europe and Japan. The prognostic relevance of KRAS status in patients with right-sided (RS), left-sided (LS), and rectal cancers was assessed. Results: Of the 1093 eligible patients, 378 had right-sided tumors and 715 had left-sided tumors. Among patients with RS tumors, the 5-year overall (OS) and recurrence-free survival (RFS) for patients with KRASmut versus wild-type tumors was not shown to differ significantly (82.2% vs. 83.2% and 72.1% vs. 76.7%, respectively, all p >.05). Among those with LS tumors, KRAS mutation was associated with shorter 5-year OS and RFS on both the univariable (OS: 79.4% vs. 86.1%, p =.004; RFS: 68.8% vs. 77.3%, p =.005) and multivariable analysis (OS: HR: 1.52, p =.019; RFS: HR: 1.32, p =.05). Conclusions: KRAS mutation status was independently prognostic among patients with LS tumors, but this association failed to reach statistical significance in RS and rectal tumors. These findings confirm reports in metastatic CRC and underline the possible biologic importance of tumor location

    Recovery kinetics of knee flexor and extensor strength after a football match

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    © 2015 The Authors. Published by PLOS. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0128072We examined the temporal changes of isokinetic strength performance of knee flexor (KF) and extensor (KE) strength after a football match. Players were randomly assigned to a control (N = 14, participated only in measurements and practices) or an experimental group (N = 20, participated also in a football match). Participants trained daily during the two days after the match. Match and training overload was monitored with GPS devices. Venous blood was sampled and muscle damage was assessed pre-match, post-match and at 12h, 36h and 60h post-match. Isometric strength as well as eccentric and concentric peak torque of knee flexors and extensors in both limbs (dominant and non-dominant) were measured on an isokinetic dynamometer at baseline and at 12h, 36h and 60h after the match. Functional (KFecc/KEcon) and conventional (KFcon/KEcon) ratios were then calculated. Only eccentric peak torque of knee flexors declined at 60h after the match in the control group. In the experimental group: a) isometric strength of knee extensors and knee flexors declined (P<0.05) at 12h (both limbs) and 36h (dominant limb only), b) eccentric and concentric peak torque of knee extensors and flexors declined (P<0.05) in both limbs for 36h at 60°/s and for 60h at 180°/s with eccentric peak torque of knee flexors demonstrating a greater (P<0.05) reduction than concentric peak torque, c) strength deterioration was greater (P<0.05) at 180°/s and in dominant limb, d) the functional ratio was more sensitive to match-induced fatigue demonstrating a more prolonged decline. Discriminant and regression analysis revealed that strength deterioration and recovery may be related to the amount of eccentric actions performed during the match and athletes' football-specific conditioning. Our data suggest that recovery kinetics of knee flexor and extensor strength after a football match demonstrate strength, limb and velocity specificity and may depend on match physical overload and players' physical conditioning level.Published versio

    The effect of two consecutive soccer games on muscle damage and performance markers

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    High‐intensity activities during a soccer game, such as sprints, accelerations, change of direction, jumps, shoot, requires high force through the Stretch – Shortening Cycle (SSC), which is associated with the exercise – induced muscle damage. Consequences of muscle damage are muscle soreness and loss of muscle power. The aim of this study was to investigate the effect of two consecutive soccer games on indices of exercise – induced muscle damage (EIMD) and physical performance (PP). In this study participated 10 soccer players (age: 20.7years, height: 177cm, weight: 73kg, body fat: 6.4%, VO2max 55 ml/kg/min) who joined the first week of experimental design without playing in matches. The second week included two soccer games which had 90 minutes duration and separated 72 hours. Measurements executed daily in the morning during first and second week up to 48 hours after the second soccer game. The EIMD determined through thigh circumferences, knee joint of range motion (KJRM) and delayed onset of muscle damage (DOMS). The PP determined through squat jump (SJ) and countermovement jump (CJ). Data was analyzed with ANOVA repeated measures. Results show that thigh circumferences were significantly different 48 hours after the first and second game, and DOMS was higher 24 and 48 hours after second game. PP deteriorated in both SJ and CJ which is ranged between 10‐20% with the greatest decrement 48 hours after the soccer games. In conclusion, the two soccer games caused noticeable changes in the EIMD and PP indices. Coaches should plan suitable training sessions after games taking account of enough recovery period for the players

    Arrowhead agility test in elite u-19 soccer players: Positional differences and relationships with other performance tests

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    Introduction. Change of direction (COD) is an important prerequisite in soccer. Therefore, a large number of tests have been developed aiming to assess the COD of athletes. The test most commonly used in soccer include the Illinois test (ICODT), the T test, the 505 test, and the Arrowhead COD test (ACODT). Aim of Study. The aim of this study was to investigate relationships between ACODT and other field tests (ICODT, 0-10 m sprint, 0-30 m sprint, countermovement jump, squat jump) in Greek elite under-19 soccer players. Comparisons were also drawn between different field positions (central defenders, side defenders, central midfielders, side midfielders, forwards). Material and Methods. Forty Greek elite male soccer players (under 19; U-19) participated in this study and were classified into the following groups: forwards, central-midfielders, side-midfielders, central-defenders, and side-defenders. Anthropometric variables of participants (height, weight, body mass index (BMI), % body fat) and anaerobic physiological parameters (10 m and 30 m sprint, squat jump, countermovement jump, Illinois COD test, Arrowhead COD test) were measured. Results. There were no significant differences between the position groups for any of the performance tests or the anthropometric measurements. There were significant correlations between ACODT for both sides (left and right) and 0-10 m time, 0-30 m time, and ICODT time. There were no significant correlations between ACODT and any of the jump performance tests. Conclusions. The lack of differences between positional roles is in contrast with other studies that addressed professional older soccer players. This fact indicates that the specification of the training may produce differences between positional roles as the performance level of the players is increasing. Greater sprinting and acceleration speed could augment ACODT performance. © 2021, University School of Physical Education. All rights reserved

    A safe and feasible “clock-face” duct-to-mucosa pancreaticojejunostomy with a very low incidence of anastomotic failure: A single center experience of 248 patients [Une technique d&apos;anastomose pancréaticojéjunale en cadran (de montre) faisable et sûre avec un taux de fistules anastomotiques très faible. Expérience monocentrique à propos de 248 patients]

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    Introduction Postoperative pancreatic fistula (POPF) is one of the most frequent and serious postoperative complications of pancreatoduodenectomy (PD). We sought to assess the impact of a novel pancreaticojejunostomy (PJ) on the rates of POPF and overall postoperative complications. Methods Between 01/2010 and 12/2013, a total of 248 consecutive patients who underwent PD with a modified PJ were identified from our database and retrospectively analyzed. POPF cases were divided into three categories (International Study Group-Guidelines [ISGPF]): biochemical fistula without clinical sequelae (grade A), fistula requiring any therapeutic intervention (grade B), and fistula with severe clinical sequelae (grade C). Perioperative outcomes were recorded and analyzed. Results The overwhelming majority of patients had no evidence of fistula. Grade A POPF was observed in 9 (3.62%), grade B in 1 (0.40%), and grade C in 0 patients. There were no postoperative deaths. Overall complications occurred in 61 patients (24.59%) of patients after PD. Conclusions This modified pancreaticojejunostomy is widely applicable and is associated with very low rates of POPF, low postoperative morbidity and mortality. Overall, it is a feasible and safe novel approach with excellent short-term outcomes. © 2016 Elsevier Masson SA
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