A randomised control trial to reduce bullying and other aggressive behaviours in secondary schools

In Australia bullying tends to peak twice in a school student\u27s life - firstly at age 1 0 to 12 and then during the two years following their transition to secondary school (Rigby, 1994; Slee, 1995b) This transition to secondary school is considered a critical period to intervene on bullying (Farrington, 1993; Rigby, 1997, 1999; Sharp, 1995; Stevens, Bourdeaudhuij, & Van Oost, 2000; Whitney & Smith, 1993). It is suggested that compared with primary schools, the change in friendship structures that accompanies the move to secondary school, large student numbers and the less consistent contact and fewer close relationships between students and staff are factors contributing to the increase in bullying at this age (Stevens, Bourdeaudhuij et al., 2000; Patton, 2000)..

Characterization of an Invertebrate-Type Dopamine Receptor of the American Cockroach, Periplaneta americana

We have isolated a cDNA coding for a putative invertebrate-type dopamine receptor (Peadop2) from P. americana brain by using a PCR-based strategy. The mRNA is present in samples from brain and salivary glands. We analyzed the distribution of the PeaDOP2 receptor protein with specific affinity-purified polyclonal antibodies. On Western blots, PeaDOP2 was detected in protein samples from brain, subesophageal ganglion, thoracic ganglia, and salivary glands. In immunocytochemical experiments, we detected PeaDOP2 in neurons with their somata being located at the anterior edge of the medulla bilaterally innervating the optic lobes and projecting to the ventro-lateral protocerebrum. In order to determine the functional and pharmacological properties of the cloned receptor, we generated a cell line constitutively expressing PeaDOP2. Activation of PeaDOP2-expressing cells with dopamine induced an increase in intracellular cAMP. In contrast, a C-terminally truncated splice variant of this receptor did not exhibit any functional property by itself. The molecular and pharmacological characterization of the first dopamine receptor from P. americana provides the basis for forthcoming studies focusing on the significance of the dopaminergic system in cockroach behavior and physiology