3,036 research outputs found
Early Molecular Responses of Tomato to Combined Moderate Water Stress and Tomato Red Spider Mite Tetranychus evansi Attack
Interaction between plants and their environment is changing as a consequence of the climate
change and global warming, increasing the performance and dispersal of some pest species which
become invasive species. Tetranychus evansi also known as the tomato red spider mite, is an invasive
species which has been reported to increase its performance when feeding in the tomato cultivar
Moneymaker (MM) under water deficit conditions. In order to clarify the underlying molecular
events involved, we examined early plant molecular changes occurring on MM during T. evansi
infestation alone or in combination with moderate drought stress. Hormonal profiling of MM plants
showed an increase in abscisic acid (ABA) levels in drought-stressed plants while salicylic acid
(SA) levels were higher in drought-stressed plants infested with T. evansi, indicating that SA is
involved in the regulation of plant responses to this stress combination. Changes in the expression of
ABA-dependent DREB2, NCED1, and RAB18 genes confirmed the presence of drought-dependent
molecular responses in tomato plants and indicated that these responses could be modulated by
the tomato red spider mite. Tomato metabolic profiling identified 42 differentially altered compounds
produced by T. evansi attack, moderate drought stress, and/or their combination, reinforcing the idea
of putative manipulation of tomato plant responses by tomato red spider mite. Altogether, these
results indicate that the tomato red spider mite acts modulating plant responses to moderate drought
stress by interfering with the ABA and SA hormonal responses, providing new insights into the early
events occurring on plant biotic and abiotic stress interaction
The formation and evolution of binary systems. III. Low-mass binaries in the Praesepe cluster
With the aim of investigating the binary population of the 700 Myr old
Praesepe cluster, we have observed 149 G and K-type cluster members using
adaptive optics. We detected 26 binary systems with an angular separation
ranging from less than 0.08 to 3.3 arcsec (15-600 AU). After correcting for
detection biases, we derive a binary frequency (BF) in the logP (days) range
from 4.4 to 6.9 of 25.3 +/- 5.4%, which is similar to that of field G-type
dwarfs (23.8%, Duquennoy & Mayor 1991). This result, complemented by similar
ones obtained for the 2 Myr old star forming cluster IC 348 (Paper II) and the
120 Myr old Pleiades open cluster (Paper I), indicates that the fraction of
long-period binaries does not significantly evolve over the lifetime of
galactic open clusters. We compare the distribution of cluster binaries to the
binary populations of star forming regions, most notably Orion and Taurus, to
critically review current ideas regarding the binary formation process. We
conclude that it is still unclear whether the lower binary fraction observed in
young clusters compared to T associations is purely the result of the early
dynamical disruption of primordial binaries in dense clusters or whether it
reflects intrinsically different modes of star formation in clusters and
associations. We also note that if Taurus binaries result from the dynamical
decay of small-N protostellar aggregates, one would predict the existence of a
yet to be found dispersed population of mostly single substellar objects in the
Taurus cloud.Comment: 10 pages, 3 figure
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Mediterranean Sea response to climate change in an ensemble of twenty first century scenarios
The Mediterranean climate is expected to become warmer and drier during the twenty-first century. Mediterranean Sea response to climate change could be modulated by the choice of the socio-economic scenario as well as the choice of the boundary conditions mainly the Atlantic hydrography, the river runoff and the atmospheric fluxes. To assess and quantify the sensitivity of the Mediterranean Sea to the twenty-first century climate change, a set of numerical experiments was carried out with the regional ocean model NEMOMED8 set up for the Mediterranean Sea. The model is forced by airâsea fluxes derived from the regional climate model ARPEGE-Climate at a 50-km horizontal resolution. Historical simulations representing the climate of the period 1961â2000 were run to obtain a reference state. From this baseline, various sensitivity experiments were performed for the period 2001â2099, following different socio-economic scenarios based on the Special Report on Emissions Scenarios. For the A2 scenario, the main three boundary forcings (river runoff, near-Atlantic water hydrography and airâsea fluxes) were changed one by one to better identify the role of each forcing in the way the ocean responds to climate change. In two additional simulations (A1B, B1), the scenario is changed, allowing to quantify the socio-economic uncertainty. Our 6-member scenario simulations display a warming and saltening of the Mediterranean. For the 2070â2099 period compared to 1961â1990, the sea surface temperature anomalies range from +1.73 to +2.97 °C and the SSS anomalies spread from +0.48 to +0.89. In most of the cases, we found that the future Mediterranean thermohaline circulation (MTHC) tends to reach a situation similar to the eastern Mediterranean Transient. However, this response is varying depending on the chosen boundary conditions and socio-economic scenarios. Our numerical experiments suggest that the choice of the near-Atlantic surface water evolution, which is very uncertain in General Circulation Models, has the largest impact on the evolution of the Mediterranean water masses, followed by the choice of the socio-economic scenario. The choice of river runoff and atmospheric forcing both have a smaller impact. The state of the MTHC during the historical period is found to have a large influence on the transfer of surface anomalies toward depth. Besides, subsurface currents are substantially modified in the Ionian Sea and the Balearic region. Finally, the response of thermosteric sea level ranges from +34 to +49 cm (2070â2099 vs. 1961â1990), mainly depending on the Atlantic forcing
Body Composition Indices and Single and Clustered Cardiovascular Disease Risk Factors in Adolescents: Providing Clinical-Based Cut-Points
ArticleThe aims of the present study in adolescents were 1) to examine how various body composition-screening tests relate to single and clustered cardiovascular disease (CVD) risk factors, 2) to examine how lean mass and body fatness (independently of each other) relate to clustered CVD risk factors and, 3) to calculate specific thresholds for body composition indices associated with an unhealthier clustered CVD risk. We measured 1089 European adolescents (46.7% boys, 12.5-17.49yr) in 2006-2007. CVD risk factors included: systolic blood pressure, maximum oxygen uptake, homeostasis model assessment, C-reactive protein (n=748), total cholesterol/high density lipoprotein cholesterol and triglycerides. Body composition indices included: height, body mass index (BMI), lean mass, the sum of four skinfolds, central/peripheral skinfolds, waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR). Most body composition indices are associated with single CVD risk factors. The sum of four skinfolds, WHtR, BMI, WC and lean mass are strong and positively associated with clustered CVD risk. Interestingly, lean mass is positively associated with clustered CVD risk independently of body fatness in girls. Moderate and highly accurate thresholds for the sum of four skinfolds, WHtR, BMI, WC and lean mass are associated with an unhealthier clustered CVD risk (all AUC > 0.773). In conclusion, our results support an association between most of the assessed body composition indices and single and clustered CVD risk factors. In addition, lean mass (independent of body fatness) is positively associated with clustered CVD risk in girls, which is a novel finding that helps to understand why an index such as BMI is a good index of CVD risk but a bad index of adiposity. Moderate to highly accurate thresholds for body composition indices associated with a healthier clustered CVD risk were found. Further studies with a longitudinal design are needed to confirm these findings
Intensive care unit discharge to the ward with a tracheostomy cannula as a risk factor for mortality: A prospective, multicenter propensity analysis
To analyze the impact of decannulation before intensive care unit
discharge on ward survival in nonexperimental conditions. DESIGN: Prospective,
observational survey. SETTING: Thirty-one intensive care units throughout Spain.
PATIENTS: All patients admitted from March 1, 2008 to May 31, 2008.
INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: At intensive care unit
discharge, we recorded demographic variables, severity score, and intensive care
unit treatments, with special attention to tracheostomy. After intensive care
unit discharge, we recorded intensive care unit readmission and hospital
survival. STATISTICS: Multivariate analyses for ward mortality, with Cox
proportional hazard ratio adjusted for propensity score for intensive care unit
decannulation. We included 4,132 patients, 1,996 of whom needed mechanical
ventilation. Of these, 260 (13%) were tracheostomized and 59 (23%) died in the
intensive care unit. Of the 201 intensive care unit tracheostomized survivors, 60
were decannulated in the intensive care unit and 141 were discharged to the ward
with cannulae in place. Variables associated with intensive care unit
decannulation (non-neurologic disease [85% vs. 64%], vasoactive drugs [90% vs.
76%], parenteral nutrition [55% vs. 33%], acute renal failure [37% vs. 23%], and
good prognosis at intensive care unit discharge [40% vs. 18%]) were included in a
propensity score model for decannulation. Crude ward mortality was similar in
decannulated and nondecannulated patients (22% vs. 23%); however, after
adjustment for the propensity score and Sabadell Score, the presence of a
tracheostomy cannula was not associated with any survival disadvantage with an
odds ratio of 0.6 [0.3-1.2] (p=.1). CONCLUSION: In our multicenter setting,
intensive care unit discharge before decannulation is not a risk factor
CMEMS downscaled circulation operational forecast system
This document describes the numerical modelling work done in task 5.2 needed to implement OSPA
Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood
Postzygotic mosaicism (PZM) in NIPBL is a strong source of causality for Cornelia de Lange syndrome (CdLS) that can have major clinical implications. Here, we further delineate the role of somatic mosaicism in CdLS by describing a series of 11 unreported patients with mosaic disease-causing variants in NIPBL and performing a retrospective cohort study from a Spanish CdLS diagnostic center. By reviewing the literature and combining our findings with previously published data, we demonstrate a negative selection against somatic deleterious NIPBL variants in blood. Furthermore, the analysis of all reported cases indicates an unusual high prevalence of mosaicism in CdLS, occurring in 13.1% of patients with a positive molecular diagnosis. It is worth noting that most of the affected individuals with mosaicism have a clinical phenotype at least as severe as those with constitutive pathogenic variants. However, the type of genetic change does not vary between germline and somatic events and, even in the presence of mosaicism, missense substitutions are located preferentially within the HEAT repeat domain of NIPBL. In conclusion, the high prevalence of mosaicism in CdLS as well as the disparity in tissue distribution provide a novel orientation for the clinical management and genetic counselling of families
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