De Rham compatible Deep Neural Network FEM

On general regular simplicial partitions $\mathcal{T}$ of bounded polytopal domains $\Omega \subset \mathbb{R}^d$, $d\in\{2,3\}$, we construct \emph{exact neural network (NN) emulations} of all lowest order finite element spaces in the discrete de Rham complex. These include the spaces of piecewise constant functions, continuous piecewise linear (CPwL) functions, the classical ``Raviart-Thomas element'', and the ``N\'{e}d\'{e}lec edge element''. For all but the CPwL case, our network architectures employ both ReLU (rectified linear unit) and BiSU (binary step unit) activations to capture discontinuities. In the important case of CPwL functions, we prove that it suffices to work with pure ReLU nets. Our construction and DNN architecture generalizes previous results in that no geometric restrictions on the regular simplicial partitions $\mathcal{T}$ of $\Omega$ are required for DNN emulation. In addition, for CPwL functions our DNN construction is valid in any dimension $d\geq 2$. Our ``FE-Nets'' are required in the variationally correct, structure-preserving approximation of boundary value problems of electromagnetism in nonconvex polyhedra $\Omega \subset \mathbb{R}^3$. They are thus an essential ingredient in the application of e.g., the methodology of ``physics-informed NNs'' or ``deep Ritz methods'' to electromagnetic field simulation via deep learning techniques. We indicate generalizations of our constructions to higher-order compatible spaces and other, non-compatible classes of discretizations, in particular the ``Crouzeix-Raviart'' elements and Hybridized, Higher Order (HHO) methods

In situ analysis of garnet inclusion in diamond using single-crystal X-ray diffraction and X-ray micro-tomography

none9A single crystal of garnet enclosed in a diamond from the Jericho kimberlite (Slave Craton, Canada) has been investigated using X-ray diffraction and X-ray micro-tomography. The novel experimental approach allowed us to determine the crystal structure of the garnet. The unit-cell edge a and fractional atomic coordinates of oxygen were used to determine the composition via an updated Margules model for garnets. The composition is Pyr(0.41(5))Alm(0.36(7))Gro(0.22(1))Uva(0.01(1)), which is indistinguishable from the eclogitic garnets found in other Jericho diamonds. We also demonstrated that residual pressures on the inclusion of up to 1 GPa do not affect significantly the determination of the garnet composition by structure refinement.noneFABRIZIO NESTOLA;M. MERLI;PAOLO NIMIS;M. PARISATTO;M. KOPYLOVA;A. DE;M. LONGO;L. ZIBERNA;M. MANGHNANINestola, Fabrizio; M., Merli; Nimis, Paolo; Parisatto, Matteo; M., Kopylova; A., De; Longo, Micaela; Ziberna, Luca; M., Manghnan

Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives

A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. The capability of some of these compound to elicit relevant repressive effects on cancer cell growth could be taken into account towards novel pharmacological approaches in cancer therapy

Ultrapermeable Polymers of Intrinsic Microporosity (PIMs) Containing Spirocyclic Units with Fused Triptycenes

Polymers of intrinsic microporosity (PIMs), such as the archetypal spirobisindane-based PIM-1, are among the most promising new materials for making gas separation membranes with high permeance for potential use in high-throughput applications. Here it is shown that ultrapermeable PIMs can be prepared by fusing rigid and bulky triptycene (Trip) to the spirobisindane (SBI) unit. PIM-SBI-Trip and its copolymer with PIM-1 (PIM-1/SBI-Trip) are both ultrapermeable after methanol treatment (PCO2 > 20 000 Barrer). Old films, although less permeable, are more selective and therefore provide data that are close to the recently redefined Robeson upper bounds for the important CO2/CH4, CO2/N2, and O2/N2 gas pairs. Temperature-dependent permeation measurements and analysis of the entropic and energetic contributions of the gas transport parameters show that the enhanced performance of these polymers is governed by strong size-sieving character, mainly due to the energetic term of the diffusivity, and related to their high rigidity. Both polymers show a relatively weak pressure-dependence in mixed gas permeability experiments up to 6 bar, suggesting a potential use for CO2 capture from flue gas or for the upgrading of biogas

Unusual sites of metastatic malignancy: case 1. Cardiac metastasis in hepatocellular carcinoma.

no abstract availabl

Long-term salvage therapy with cyclosporin A in refractory idiopathic thrombocytopenic purpura

Treatment of severe, chronic idiopathic thrombocytopenic purpura (ITP) refractory to most usual therapies is a difficult challenge. Little information exists on the clinical use of cyclosporin A (CyA) in the treatment of ITP. This report describes long-term treatment with CyA (median, 40 months) and follow-up (median, 36.8 months) in 12 adult patients with resistant ITP. CyA used in relatively low doses (2.5-3 mg/kg of body weight per day) led to a clinical improvement in 10 patients (83.3%). Five had a complete response (41.1%), 4 a complete response to maintenance therapy (33.3%), and one a partial response (8.3%). Two patients had no response. Most patients with a response (60%) had a long-term remission (mean, 28.6 months) after discontinuation of CyA. One patient had a relapse of ITP 4 years after CyA therapy was stopped. Side effects were moderate and transient, even in patients dependent on continued CyA treatment. CyA seems to represent reasonable salvage treatment in severe, potentially life-threatening, refractory ITP

Chapter Interventi di tutela e valorizzazione della biodiversità del SIC ”Torre dell’Orso"- IT 9150004

The project for the enhancement of the SIC IT9150004 (POR Puglia 2014/2020 Axis VI Environmental protection and promotion of natural and cultural resources - Interventions for the protection and enhancement of terrestrial and marine biodiversity) involves the enhancement of the Brunese Canal which makes it a fundamental infrastructure through the upgrading of the waterway, the coordination between environmental and rural development policies, the redevelopment and recovery of the landscape of its compromised areas together with the reduction of the pollution and the consequent improvement in the quality of the water poured into the sea

Stroke and Systemic Lupus Erythematosus: A Review

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that involves collagen tissue throughout the body. Several previous studies have shown that the risk of ischaemic and haemorrhagic stroke is significantly higher in SLE when compared to the general population, particularly in young individuals, representing one of the principal causes of death in these patients. Though the precise pathophysiology behind this increased risk is still poorly understood, several mechanisms are suggested to play a role. The high burden of cerebral small vessel disease features noted on brain neuroimaging studies, as well as the accelerated process of atherosclerosis identified in these patients, are likely to be responsible for at least some of the ischaemic strokes occurring in the SLE population. Repeated episodes of arterial and venous thrombosis secondary to antiphospholipid syndrome are likewise important. Less is known regarding the exact pathophysiological relationship between SLE and the high incidence of haemorrhagic stroke, though thrombocytopenia and a greater susceptibility to form typical and atypical brain aneurysms, which may then rupture, are thought to be the main mechanisms responsible for the occurrence of intracerebral and subarachnoid haemorrhage, respectively. Both inflammatory and noninflammatory events, all involving the immune system, are responsible for several pathological changes affecting cerebral vessels of every calibre in SLE, as confirmed by histopathology. In this context, endothelial activation and dysfunction play a critical role. This review will briefly analyse the most important factors responsible for the higher ischaemic and haemorrhagic stroke risk in the SLE population, with a particular focus on brain vascular changes