3-Chloro-N-(4-meth­oxy­phen­yl)propanamide

The title compound, C10H12ClNO2, is a halogenated derivative of a secondary amide bearing an aromatic substituent. The C(=O)—N(H)—Car—Car torsion angle of −33.70 (18)° rules out the presence of resonance spanning the amide as well as the aromatic system. In the crystal, classical N—H⋯O hydrogen bonds, as well as C–H⋯O contacts connect the mol­ecules into chains propagating along the a axis

Facile thermal rearrangement of Lorazepam and Oxazepam

1628-1632  Lorazepam 1, a very well known anti-convulsant undergo facile thermal rearrangement at about 110°C to 6-chloro-4-(o-chlorophenyl)-2-Quinazolinecarboxaldehyde 10 in almost quantitative yield. Oxazepam 2 which is structurally similar, require higher temperature for the similar rearrangement to give 6-chloro-4-phenyl-2-quinazolinecarboxaldehyde 11. However, structurally similar temazepam 3 did not undergo this rearrangement. </span

6-Chloro-2-chloromethyl-4-phenylquinazoline 3-oxide

In the title compound, C15H10Cl2N2O, the dihedral angle between the mean planes of the phenyl ring and the 10-membered quinazoline ring is 63.3 (4)°. In the crystal, pairs of weak C—H...O interactions link the molecules into centrosymmetric dimers, forming R22(10) graph-set ring motifs. In addition, weak π–π stacking interactions [minimum centroid–centroid separation = 3.6810 (8) Å] are observed, which contribute to the formation of a supramolecular assembly in the packing array