7 research outputs found
Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world
- Author
- Abad Pedro
- Abbara Suhny
- Abbasi Taimur
- Abbott Brian
- Abdel Aziz Islam Shawky
- Abdulla Jawdat
- Abikhzer Gad
- Abohashem Shady
- Abougabal Mahasen
- Abramson Sandra
- Abrihan Paz
- Acuña Arturo Romero
- Affandi Erwin
- Afzal Muhammad Shehzad
- Agolti Mariela
- Agranovich Svetlana
- Aguadé-Bruix Santiago
- Aguero Roberto Nicolas
- Ahmed Hassan Mohamed Ismail
- Ahmed Taghreed
- Akhter Afroza
- Al Dhuhli Humoud
- Al Kindi Faiza
- Al-Abboud Tarek
- Al-Bulushi Naeema
- Al-Mallah Mouaz
- Alak Maria del Carmen
- Alam Edison
- Alaoui Nadia Ismaili
- Alasnag Mirvat
- Albadr Amjed
- Albalooshi Batool
- Albano Domenico
- Alberguina Lucia Graciela
- Albernaz Siqueira Maria Helena
- Alexanderson-Rosas Erick
- Alfaro Ana
- Ali Mohamed Mandour
- Alkadhi Hatem
- Alkandari Faridah
- Allam Adel
- Allarakha Mohammad Aaftaab
- Almeida Augusto
- Almousalli Omar
- Alongi Pierpaolo
- Alonso Omar
- Alves Togni Paulo Henrique
- Alves Wilson Furlan
- Ananthasubramaniam Karthikeyan
- Anderson Jill
- Andrade Jose Henrique
- Andrade Luciana
- Angelidis George
- Anselmi Carlos
- Ansheles Alexey
- Araújo Roberta
- Archontaki Aikaterini
- Arnone Gaspare
- Arnous Samer
- Arnson Yoav
- Arroñada Guillermo
- Arturo Harold
- Asano Hiroshi
- Ascani Sebastian Perez
- Asfour Ahmed
- Askew Jeffrey
- Assadi Majid
- Astesiano Alfredo
- Astesiano Andrea
- Attanasio Lea
- Atyani Said
- Ayala Sandra
- Ayetey Harold
- Ayodele Tolulope
- Azevedo Guilherme
- Bagatin Elisa
- Bailly Matthieu
- Baldari Sergio
- Balmer-Swain Mallory
- Bang Ji-In
- Banthia Nilesh
- Bar-Shalom Rachel
- Barette Rene
- Baric Ana
- Barneveld Peter
- Barragan Adriana Puente
- Barragan Erika
- Barroso Asela
- Basavaraj Ashok Gangasandra
- Batinic Tonci
- Batista Juan Felipe
- Batyrkhanov Daultai
- Bauckneht Matteo
- Baugh Dainia
- Bayer Richard R.
- Bedi Punit
- Bejai Shereen
- Ben-Rais Nozha
- Benedek Imre
- Benedek Theodora
- Benitez Luis
- Benlabgaa Rabie
- Bennie George
- Benteo Pablo
- Beretta Mario
- Berman Daniel S.
- Bernheim Adam
- Bertelli Paolo
- Bester Ria
- Bettencourt Nuno
- Better Nathan
- Better Nathan
- Beuzeville Scott
- Bezerra Sabbrina
- Bhagat Jinendra Kumar
- Bhargava Rishi
- Bhat Vivek
- Bhatia Mona
- Bhatti Sabha
- Biancardi Rodrigo
- Bianco Francesco
- Bieging Erik
- Biggans Thomas
- Bittencourt Marcio Sommer
- Blanco Isabel
- Blanco Juan
- Blankstein Ron
- Blankstein Ron
- Bloom Stephen
- Blue Sean
- Bluemke David
- Bluemke David A.
- Boktor Raef
- Bom Henry
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- Bonfiglioli Rachele
- Boni Roberto
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- Branch Kelley
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- Bularga Anda
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- Bullock-Palmer Renée
- Burandt Angela
- Burg Samuel
- Burger Peter
- Burgul Rajesh
- Burke Floyd W.
- Bush Kelvin
- Busnardo Elena
- Bustos Jose Javier
- Butler Patrick
- Byrne Angela
- Bøttcher Morten
- Cabada Manuel
- Cabeda Estevan Vieira
- Cabrejas Raul
- Cabrera Antonio
- Cachero Jorge
- Cadena Alberto
- Caicedo Carlos
- Calcott Jennifer
- Califaretti Elena
- Camarero Alicia
- Camoni Luca
- Campisi Roxana
- Canal Maria Pedrera
- Candela Candace
- Canderoli Alejandro
- Canessa Jose
- Cantinho Guilhermina
- Cao Dianbo
- Capasso Elizabeth
- Carames Silvia
- Carnevale Aldo
- Carpenter John-Paul
- Carr Loretta
- Carrascosa Patrícia
- Carreira Lara
- Carvajal-Juarez Isabel
- Casoni Roberta
- Castro Bruno
- Castro Gabriel
- Castro Ricardo
- Casáns-Tormo Irene
- Cavalcante Joao
- Cavallo Armando Ugo
- Cavenaghi Giorgio
- Cendoya Oscar
- Cerci Rodrigo
- Cerci Rodrigo J.
- Ceriani Luca
- Chambers Duane
- Chan Virgil
- Chang Donald
- Chang Tien
- Chao Charles
- Chatterjee Saurav
- Chatziioannou Sofia
- Chatzizisis Yiannis
- Cheezum Michael
- Chen Jennifer
- Chen Marcus
- Chen Tiffany
- Cheung Stephen
- Chierichetti Franca
- Chimura Chimura Misato
- Chiocchi Marcello
- Cho Sang-Geon
- Choi Andrew
- Choi Andrew
- Choi Andrew D.
- Chong Woon
- Choudhury Partha
- Chow Benjamin
- Chowdekar Vijay Sai
- Christensen Mette
- Cittanti Corrado
- Clarcq James
- Cognigni Luciano Martin
- Cohen Yosef
- Cohen Yosef A.
- Coie Tchoyoson Lim
- Coles Duncan
- Collaud Carlos
- Collaud Carlos
- Colletta Mauro
- Concha Carmen
- Conti Umberto
- Cordero Ayreen
- Cortes Claudia
- Cortés Filiberto
- Cortés Violeta
- Cossu Alberto
- Courtis Javier
- Cragnolino Daniel
- Crim Matthew
- Cruz Eric
- Cuadra Teresa
- Cuellar-Calabria Hug
- Cunali Fernando
- Cuocolo Alberto
- Cury Roberto
- Cusack David
- Cuzzocrea Marco
- Dabreo Dominique
- Dai Xu
- Daicz Mariana
- Danciu Sorin
- Dantas Roberto
- Dariy Olga
- Datseris Ioannis
- Dautov Tairkhan
- de Amorim Fernandes Fernando
- De Boeck Bart
- De Carvalho Filipe Penna
- De La Peña Erasmo
- De La Vega Alejandro
- De Lorenzo Andrea
- De Macedo Filho Robson
- De Maria Silvia Teresa
- De Rimini Maria Luisa
- De Souza Thiago Ferreira
- De Vincentis Giuseppe
- Decter Bruce
- Del Giudice Eleonora
- Del Riego Horacio
- Del Torto Alberico
- Della Tommasina Veronica
- Deshpande Aparna
- Dettori Fernando
- Deux Jean-François
- Deviggiano Alejandro
- Dhruva Nimish
- Diaz Javier Lopez
- Djuraev Omoa
- Dobson Mark
- Doherty Neil
- Dondi Maurizio
- Dondi Maurizio
- Dorbala Sharmila
- Dorbala Sharmila
- Dougan John
- Doukky Rami
- Downie D'Arne
- Dragonetti Laura
- Drozdova Olga
- Dunbar Anjori
- Durmo Rexhep
- Duvall William
- Dwivedi Girish
- Edmond John
- Edwards Rachael
- Efros-Monsen Elen
- Einstein Andrew J.
- Einstein Andrew J.
- Elison Barry
- Ellis Chris
- Emami Farshad
- Embon Mario
- Engela Jean
- Engelbrecht Gerrit
- Engelmann Vaclav
- Enriquez Ruben Emilio
- Ensinas Jorge
- Erba Paola Anna
- Erthal Fernanda
- Escobar Manuel Valencia
- Escorza Velez Giovanni Alejandro
- Espeche Maria del Huerto Velazquez
- Esquitin Kerry
- Evangelista Laura
- Evbuomwan Osayande
- Faccio Fernando
- Facello Adolfo
- Fairbairn Timothy
- Faletti Riccardo
- Faragasso Evelina
- Faraggi Marc
- Farah Husam
- Farrugia Alexia
- Farsad Mohsen
- Fatima Shazia
- Fentanes Emilio
- Ferencik Maros
- Ferencik Maros
- Fernandes Fabio
- Fernandes Fabio
- Fernandes Juliano
- Ferrando Rodolfo
- Ferreira Antonio
- Ferro Paola
- Feuchtner Gudrun
- Fisher Daniel
- Fitzpatrick Daniel
- Flores Ana Camila
- Florimonte Luigia
- Flotats Albert
- Forsdahl Signe Helene
- Foster Cameron
- Fragkaki Christina
- Franceschi Maja
- Francis Roslyn
- Frantellizzi Viviana
- Frenkel Alex
- Friedrich Matthias
- Fringuelli Fabio Massimo
- Fuentes Cañamero Maria Eugenia
- Fuisz Tony
- Fujimoto Shinichiro
- Fujisue Koichiro
- Fukunaga Tomohisa
- Fukushima Yoshimitsu
- Fukuyama Kae
- Gagarina Nina
- Gaikwad Anand
- Gama-Moreno Manlio
- Gamboa Isabel Berrocal
- Gannon Michael
- Garai Ildiko
- Garashi Masoud
- Garcheva-Tsacheva Marina
- García María Elia
- Garg Ria
- Garofalo Diego
- Gastner Lori
- Gatti Marco
- Gaudiano Angela
- Georgoulias Panagiotis
- Geronazzo Ricardo
- Gerson Myron
- Gheysens Olivier
- Ghimire Ram Kumar
- Ghini Bruno
- Ghoshhajra Brian
- Gimelli Alessia
- Girijanandan Mahapatra Prof Dr
- Giubbini Raffaele
- Giuffrida Francesca
- Glaudemans Andor
- Gleeson Tadhg
- Goda Artan
- Goebel Benjamin
- Goebel Benjamin
- Goldberg Alan
- Goldner Brian
- Gomez Marie Rhiamar
- Gomez Sharon
- Goncalves Luiz
- Gong Lianggeng
- Gongxeka Harlem
- Gonza Natalia
- Gonzalez Carla
- Gonzalez Jorge
- González Luis
- González Ulises
- González-Montecinos Alejandro Becerril
- Goodwin Bruce
- Gopalan Deepa
- Gore Rosco
- Gormsen Lars Christian
- Gottlieb Ilan
- Gracia-López Sandra
- Greenough Robert
- Grossman Gabriel Blacher
- Gräni Christoph
- Gulyaev Vsevolod Milyevich
- Gummow Alistair
- Gunawan Gani
- Gutierrez Villamil Claudia T.
- Gutierrez Goleat
- Gutierrez Lucas
- Gutierrez Yamile Marcos
- Gutierrez Yamile Marcos
- Guzzo Miguel Angel
- Guzzo Miguel Angel
- Gómez Lauchy Juan Manuel
- Habets Jesse
- Habouzit Vincent
- Hadlich Marcelo
- Hafez Mohammed Nassoh
- Hage Fadi
- Haidar Mohamad
- Haider Agha
- Haider Sofia
- Hamilton Mark
- Hamilton-Craig Christian
- Hamirani Yasmin
- Han Dan
- Hapkido Habusari
- Harbinson Mark
- Hartley Thomas
- Hasbak Philip
- Hasbani Victor
- Hashimoto Jun
- Hassan Alia
- Hassan Mona
- Hassen Karen
- Hatfield Mallory
- Hawkins Carolyn
- Hawthorne Katie
- Heath Nicholas
- Hendel Robert
- Hernandez Phillip
- Hernández Gertrudis Sabatel
- Herrera Yariela
- Hess Søren
- Hidalgo Pablo
- Hidayat Basuki
- Hildre Dimmen Jenni-Mari
- Hill Gregory
- Hinterleitner Gerd
- Hirschfeld Cole B.
- Hirschfeld Cole B.
- Holdgaard Paw
- Homans Filip
- Hong Chae Moon
- Horgan Stephen
- Hou Yang
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- Hsieh Victar
- Hua Shaw
- Huda Aulia
- Hudson Benjamin
- Huerin Melina
- Huffman Jeff
- Hurwitz Lynne
- Hyafil Fabien
- Ialuna Salvatore
- Ibrahim Ahmed
- Ichikawa Yasutaka
- Iguchi Nobuo
- Iii George Kinzfogl
- Ilic Srdja
- Imai Masamichi
- Inaki Anri
- Irodi Aparna
- Ishimura Hayato
- Iskandrian Ami
- Isobe Satoshi
- Issoufou Djibrillou Moussa
- Itskovich Irina
- Jaimes Claudia
- Jain Shashank
- Janardhanan Rajesh
- Jang Su Jin
- Jason See Jia Hao
- Jawa Zabah
- Jellis Christine
- Jeong Yong Hyu
- Jerome Scott
- Jimenez-Heffernan Amelia
- Jiménez-Santos Moisés
- Johansen Allan
- Johnson Chris
- Johnson Kerryanne
- Joseph Elizabeth
- Joshi Nikhil
- Joshi Subodh
- Juillet de Saint Lager Lucas Alix
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- Junior José Soares
- Jäger Victor
- Jørgensen Arve
- Kadokami Toshiaki
- Kaffas Sameh
- Kalinin Artem
- Kalnina Marika
- Kalra Dinesh
- Kamani Christel H.
- Kameoka Vinícius
- Kaminek Milan
- Kandeel Ahmed
- Kang Won Jun
- Kapitan Miguel
- Kaplan Mitchell
- Karalkin Anatoly
- Karim Noor Khairiah A.
- Kato Takao
- Kaviratne Summanther
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- Kay Fernando
- Kay Michael
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- Pascual Thomas N. B.
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- Shaw Leslee J.
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- Solari Lucrecia
- Soldat-Stankovic Valentina
- Soli Idrissa Adamou
- Soman Prem
- Sood Aditya
- Sood Ashwani
- Sperandio Massimiliano
- Spiro Bernardo
- Srichai-Parsia Monvadi Barbara
- Stan Claudiu Adrian
- Stankovic Sinisa
- Stanton Tony
- Stavrou Petros
- Stefanelli Antonella
- Steffensen Rolf
- Strada Bruno
- Streeter James
- Strouhal Peter
- Stuart Murch
- Stubbs Michael
- Subedi Deepak
- Sueldo Claudio Pereyra
- Sun Kai
- Suwa Yoshinobu
- Swainson Ian
- Syawaluddin Hilman
- Syed Ghulam
- Szilveszter Balint
- T Albert
- Tacher Vania
- Tag Naima
- Takanami Kentaro
- Takehana Kazuya
- Taki Junichi
- Taleb Sara
- Tamaki Nagara
- Tandon Vikas
- Tang Gongshun
- Tang Jeanelle Margareth
- Taniguchi Yasuyo
- Taubman Kim
- Tawakol Ahmed
- Taylor Andrew
- Tecson Bettina
- Teragawa Hiroki
- Theng Youdaline
- Thientunyakit Tanyaluck
- Thimister Paul
- Thomas Dustin
- Thomas Paul
- Thomassen Anders
- Thompson Randall
- Thu Phyo Si
- To Andrew
- Tomas Miguel Santaularia
- Tomizawa Nobuo
- Topping William
- Torbet Tara
- Torreao Jorge
- Torres Rafael
- Traverso Sonia
- Traverzo Sonia Simona
- Trifonova Tatjana
- Trinidad Desiree
- Trivedi Adwait
- Tsujita Kenichi
- Tweed Katharine
- Udugama Chandraguptha
- Uellendahl Marly
- Ullery Shawn
- Umeji Kyoko
- Unger Steven
- Unzek Samuel
- Upton Anthony
- Uretsky Seth
- Uson Kristine Joy
- Ussov Wladimir Yurievich
- Uusitalo Valtteri
- Uy Mila
- Vajauskas Donatas
- Vakhromeeva Margarita
- Valiullina Nailya
- Vallejo Enrique
- Valles Mario
- Vallurupalli Srikanth
- Vallée Jean-Paul
- Valsamaki Pipitsa
- Vamadevan Shankar
- Van Asperen Erik-Jan
- Van De Heyning Caroline M.
- Van Gaal William
- Van Pelt Niels
- Vangu Mboyo
- Vargas Luis Salazar
- Vasquez Andres
- Vavlukis Marija
- Velez Mayra Sanchez
- Veltman Niels
- Ventroni Guido
- Vergel Damiana
- Verjans Johan
- Verma Atul
- Verma Vikas
- Verschure Derk
- Veríssimo Otávia
- Villines Todd C.
- Villines Todd C.
- Vitola Joao V.
- Vitola Joao V.
- Vondrak Andrej
- Voutnis Demetrius
- Vuuren Magritha Jv
- Várady Edit
- Vázquez Manuel Castillo
- Wagenaar Nils
- Wakabayashi Yasushi
- Waller Alfonso
- Waltrick Roberto
- Wang Ellen
- Wang Jian
- Wang Ximing
- Wang Yifan
- Wang Yining
- Wang Zhao-Qian
- Ward Parker
- Wayne Victor
- Weihmuller Juan Sebastian
- Weir-Mccall Jonathan
- Weiss Konrad
- Weissman Gaby
- Wesbey George
- White James
- White Kelly
- Williams Michelle C.
- Williams Michelle C.
- Wilson Peter
- Winchester David
- Winchester David
- Wolcan Juan
- Wolinsky David
- Won Kyoung Sook
- Wong David
- Wong Kirby
- Wu Jiang
- Wu Zhifang
- Xia Liming
- Xiao Jiangxi
- Xu Lei
- Xu Zhuoran
- Yamada Shinichiro
- Yamazaki Shinya
- Yang Youyou
- Yew Min Sen
- Yin Wu
- Yoneyama Tatsuya
- Yost Sandra
- Young Calum
- Younger John
- Younis Muhammad Numair
- Yu Jianqun
- Yuan Li
- Zaid Eed Abu
- Zakavi Seyed Rasoul
- Zapparoli Marcello
- Zavadovsky Konstantin
- Zeffiro Susana
- Zeidán Nahla
- Zerahn Bo
- Zgaljardic Michael
- Zhang Longjiang
- Zhang Tong
- Zhang Xiaoli
- Zhang Yong-Gao
- Zhu Li
- Zhuravlev Kirill
- Zoboli Stefania
- Zukotynski Katherine
- Zuluaga Alejandro
- Øvrehus Kristian Altern
- Štalc Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality.
Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States.
Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis.
Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection
Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial
- Author
- Aguirre-García Gloria Mayela
- Ahuad Guerrero Rodolfo Andres
- Ahuad Guerrero Rodolfo Andrés
- Arana-Arri Eunate
- Arancibia Luna Lesly Angela
- Arias Hoo Dommie Janneth
- Aroca Martinez Gustavo Jose
- Arredondo Saldaña Felipe
- Ascaso del Río Ana
- Balmaceda Maria Pia
- Barrera Perigault Paulo
- Bautista Toloza Leonardo
- Bobat Antonela
- Boersma Wim
- Boggia Bruno Emilio
- Bonten Marc
- Borchowiek Silvina
- Braida Ariel
- Brecx Alain
- Bustinduy Odriozola Maria Jesus
- Camacho Choza Laura Julia
- Camara Anais
- Candelario Rosalba
- Carbajal Paulet Óscar
- Castella Sofia
- Castro Castrezana Laura
- Celis Carlos R.
- Chan Milagros
- Chandler Reynaldo
- Cheatham-Seitz Darline
- Chávez Barón Jaime
- Collazos Lennis Maria Fernanda
- Cornejo Enrique
- Cornejo Rubelio E.
- Corral Gonzalo
- de Bie Jessie
- de Block Eddie Jan Louis
- de Jonge Hanna K.
- de la Flor Carolina
- de Winter Ronald Frank Jacobus
- DeAntonio Rodrigo
- Diaz-Parra Carmen
- Diez Fabián
- Dittrich Ricardo Julio
- Djamin Remco
- Donastorg Yeycy
- Durigan Virginia
- Durán Laviña María Isabel
- Eberts Sandra
- Ecker Lucie
- Escobar Johnny
- Esen Meral
- Espínola Lidia
- Fendel Rolf
- Fernandez Alberto
- Fleischmann Wim Alexander
- Flores Omar
- Foccoli Monica
- Gabor Julian Justin
- Gallego Mikel
- Ganaha Maria Cristina
- Garcia Lopez Carlos Alberto
- García Cruz Johanna Marcela
- García-de-Vicuña Aitor
- Gil Ana I.
- Gonzales Lucy
- González Limón Pablo
- Gorini Nestor
- Granados González María Angélica
- Grandez Castillo Gustavo Alberto
- Grazziani Franco
- Gregoraci Giorgia
- Grobusch Martin P.
- Guardiani Fernando Martin
- Guzman Quintanilla Fernanda
- Guzman Esperanza
- Hammerschlag Icaza Bruno
- Herrera Sanchez Javier
- Hessels Lisa
- Horn Carola
- Hrabar Adrian D.
- Huber Kristina
- Imaz-Ayo Natale
- Junker Helga
- Kimura Alan
- Koehne Erik
- Kreidenweiss Andrea
- Kremsner Peter G.
- Kroidl Arne
- Köhler Carsten
- Ladino González Margot Cecilia
- Lama Javier R.
- Lambert Sandra
- Lanata Claudio F.
- Lantigua Flavia
- Laredo Velasco Leonor
- Larrea Arranz Igor
- Lehmann Clara
- Leroux-Roels Isabel
- Longhi Andrea
- Lovesio Luciano
- Luján Palacios Juan de Dios
- Mann Philipp
- Martella Carolina
- Martinez Avendaño Alejandro
- Martinez-Reséndez Michel Fernando
- Martínez Alcorta Luis Ignacio
- Mastruzzo María
- Matta Aguirre Milagros Erika
- Mayorga Valerie
- Mazara Rosario Sonia
- Mazo Elorza Diana Patricia
- Meijide Susana
- Morales-Oliva Jose
- Nemi Sergio Andrés
- Ochoa Mayra
- Ochoa Theresa J.
- Olmos Vega Jocelyn
- Oostvogels Lidia
- Ortega Dominguez Sandra Janeth
- Pedernera Aldana
- Peña Mendez Lourdes
- Peña Bia
- Peña Moisés
- Piedimonte Fabián C. sar
- Portolés-Pérez Antonio
- Potito Roberto
- Poy Carlos Alberto
- Prieto Pradera I. igo
- Quintini Gianluca
- Ramírez Lamas Suzanne Pamela
- Rebollon Gabriel
- Reyes Fentanes Maria Jose
- Reyes Gilda
- Reynales Londoño Humberto
- Ricalde Sheby A.
- Rios Nogales Luis
- Rivera Mejia Luis Maria
- Rivera Laura
- Rodríguez Ordoñez Paula Andrea
- Rojas Marianela
- Rosario Gomez Nadia
- Ruiz Herrera Vida Veronica
- Ruiz Palacios y Santos Guillermo Miguel
- Ruiz Sergio
- Sanes Fatima
- Santorcuato Ana
- Schnyder Jenny L.
- Schunk Mirjam
- Schönborn-Kellenberger Oliver
- Seibel Tobias
- Sierra Garcia Alexandra
- Solano Mosquera Lina Marianur
- Sáez-Llorens Xavier
- Tartaglione Javier Gerardo
- Thiel Verena
- Torres Almanzar Dania
- Torres Hernandez Daniela
- Torres Quiroz Ivonne Aimee
- Vahrenhorst Dominik
- Valdiviezo Gladys
- van der Sar Simone
- Vanegas Dominguez Beatriz
- Vecchio Claudia
- Vega Orozco Karen Sofia
- Vergara Itziar
- Verstraeten Thomas
- Vico Marisa
- Vidal Jhonny
- Vázquez Saldaña Eduardo Gabriel
- Vázquez Villar Andrea
- Walz Lisa
- Webb Camille María
- Wong t Digna Y.
- Zalatnik Viviana Judith
- Zambrano Ochoa Adriana Pilar
- Zambrano Ortiz José
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2022
- Field of study
Background: Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate. Methods: HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18–60 years and ≥61 years), adults with no history of virologically confirmed COVID-19 were randomly assigned (1:1) to receive intramuscularly either two 0·6 mL doses of CVnCoV containing 12 μg of mRNA or two 0·6 mL doses of 0·9% NaCl (placebo) on days 1 and 29. The primary efficacy endpoint was the occurrence of a first episode of virologically confirmed symptomatic COVID-19 of any severity and caused by any strain from 15 days after the second dose. For the primary endpoint, the trial was considered successful if the lower limit of the CI was greater than 30%. Key secondary endpoints were the occurrence of a first episode of virologically confirmed moderate-to-severe COVID-19, severe COVID-19, and COVID-19 of any severity by age group. Primary safety outcomes were solicited local and systemic adverse events within 7 days after each dose and unsolicited adverse events within 28 days after each dose in phase 2b participants, and serious adverse events and adverse events of special interest up to 1 year after the second dose in phase 2b and phase 3 participants. Here, we report data up to June 18, 2021. The study is registered at ClinicalTrials.gov, NCT04652102, and EudraCT, 2020–003998–22, and is ongoing. Findings: Between Dec 11, 2020, and April 12, 2021, 39 680 participants were enrolled and randomly assigned to receive either CVnCoV (n=19 846) or placebo (n=19 834), of whom 19 783 received at least one dose of CVnCoV and 19 746 received at least one dose of placebo. After a mean observation period of 48·2 days (SE 0·2), 83 cases of COVID-19 occurred in the CVnCoV group (n=12 851) in 1735·29 person-years and 145 cases occurred in the placebo group (n=12 211) in 1569·87 person-years, resulting in an overall vaccine efficacy against symptomatic COVID-19 of 48·2% (95·826% CI 31·0–61·4; p=0·016). Vaccine efficacy against moderate-to-severe COVID-19 was 70·7% (95% CI 42·5–86·1; CVnCoV 12 cases in 1735·29 person-years, placebo 37 cases in 1569·87 person-years). In participants aged 18–60 years, vaccine efficacy against symptomatic disease was 52·5% (95% CI 36·2–64·8; CVnCoV 71 cases in 1591·47 person-years, placebo, 136 cases in 1449·23 person-years). Too few cases occurred in participants aged 61 years or older (CVnCoV 12, placebo nine) to allow meaningful assessment of vaccine efficacy. Solicited adverse events, which were mostly systemic, were more common in CVnCoV recipients (1933 [96·5%] of 2003) than in placebo recipients (1344 [67·9%] of 1978), with 542 (27·1%) CVnCoV recipients and 61 (3·1%) placebo recipients reporting grade 3 solicited adverse events. The most frequently reported local reaction after any dose in the CVnCoV group was injection-site pain (1678 [83·6%] of 2007), with 22 grade 3 reactions, and the most frequently reported systematic reactions were fatigue (1603 [80·0%] of 2003) and headache (1541 [76·9%] of 2003). 82 (0·4%) of 19 783 CVnCoV recipients reported 100 serious adverse events and 66 (0·3%) of 19 746 placebo recipients reported 76 serious adverse events. Eight serious adverse events in five CVnCoV recipients and two serious adverse events in two placebo recipients were considered vaccination-related. None of the fatal serious adverse events reported (eight in the CVnCoV group and six in the placebo group) were considered to be related to study vaccination. Adverse events of special interest were reported for 38 (0·2%) participants in the CVnCoV group and 31 (0·2%) participants in the placebo group. These events were considered to be related to the trial vaccine for 14 (<0·1%) participants in the CVnCoV group and for five (<0·1%) participants in the placebo group. Interpretation: CVnCoV was efficacious in the prevention of COVID-19 of any severity and had an acceptable safety profile. Taking into account the changing environment, including the emergence of SARS-CoV-2 variants, and timelines for further development, the decision has been made to cease activities on the CVnCoV candidate and to focus efforts on the development of next-generation vaccine candidates. Funding: German Federal Ministry of Education and Research and CureVac
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
- Boerries Brandenburg
- Brandie Taylor
- Brandon J. Essink
- Brandy Ball
- Breanz Watkins
- Brenda Dorcely
- Brendan Levy
- Brett Gray
- Brett Leav
- Brian D.W. Chow
- Brit Sovic
- Brittany Feijoo
- Brittany Stewart
- Bruce C. Gebhardt
- Bruce G. Rankin
- Bruce McClenathan
- Bruno Valenti
- Bryan Gordon
- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
- Carl Fichtenbaum
- Carl P. Griffin
- Carlos A. Fierro
- Carlos del Rio
- Carlos Lopez
- Carlos Malvestutto
- Carmel B. Dyer
- Carmen A. Paez
- Carmen Amador
- Carmen D. Zorrilla
- Carmen Medina
- Carol Ann Linebarger
- Carol Kauffman
- Carol L. Mitchell
- Carolene Stephenson
- Caroline Greene
- Carolyn Scatamacchia
- Carolyn Tran
- Carrie Johnston
- Carrie Sopher
- Catherine A. Bunce
- Catherine Mary Healy
- Catherine Q. Gular
- Cathy Laflan
- Cecilia McKeown-Bragas
- Celia Gonzalez
- Celia Maxwell
- Charles Harper
- Charles M. Fogarty
- Charlotte-Paige Rolle
- Charnell Cromer
- Chelsea Miles
- Chelsie Nutsch
- Chelsie Nutsch
- Chen S. Tan
- Chenchen Yu
- Cheryl Nuss
- Cheryl Young
- Chimeremma Nnadi
- Chinar Desai
- Christian Tomaszewski
- Christina A. Rostad
- Christina Bacher
- Christina Kennelly
- Christine Akamine
- Christine B. Turley
- Christine Hull
- Christine Wilson
- Christopher Carpenter
- Christopher Dedon
- Christopher Galloway
- Christopher Matich
- Christy Schmeck
- Christy Sweet
- Clarence B. Creech II
- Clarisse Baudelaire
- Claudia De La Matta Rodriguez
- Claudia Espinosa
- Claudio Nuñez Lagos
- Clint C. Guillory
- Clint Wilson
- Codi M. Anthony
- Colleen F. Kelley
- Colleen Jacobsen
- Connie Moya
- Cora Sonnier
- Corey G. Anderson
- Corey M. Chen
- Cornell Calinescu
- Corrina Pavetto
- Cortney Burch
- Cory J. Huffine
- Craig Dietz
- Cristina Cicogna
- Crystal Rowell
- Cynthia Becher Strout
- Cynthia Brown
- Cynthia Bueno
- Cynthia L. Gay
- Cynthia L. Monaco
- Cynthia Montano-Pereira
- Cyrus Hoseyni
- Dakotah C. Lane
- Dalia Tovar
- Daniel Duncanson
- Daniel Hoft
- Daniel Kaul
- Daniel S. Graciaa
- Daniel T. Lawler
- Daniela Pineda Méndez
- Danielle Raley
- Danny Sugimoto
- Danyel Johnson
- Darlene Bartilucci
- David B. Musante
- David Beckmann
- David Browder
- David Dellaero
- David Fitz-Patrick
- David Halpert
- David I. Bernstein
- David J. Diemert
- David J. Ensz
- David Kline
- David L. Fried
- David Metzger
- David Pampe
- David Pitrak
- David R. Andes
- David Rosenberg
- David Tatelbaum
- David Wohl
- Dawn Furey
- Dawn Robison
- Dean Follmann
- Dean M. Boswell
- Deanna Cooper
- Debora Dunbar
- Deborah A. Theodore
- Deborah Murray
- Debra B. Schroeck
- Delia Bullock
- Denis Tarakjian
- Denise Casey
- Denise Roadman
- Denise Sample
- Denisse Alejandra González Estrada
- Derek Lewis
- Derek M. Smith
- Destiny S. Heinzig-Cartwright
- Diana Badillo
- Diana F. Florescu
- Diana Vegas
- Dianca Sierra
- Diane H. Johnson
- Dilek Ince
- Dima Dandachi
- Dirk Heerwegh
- Dolores Rijos
- Donald M. Brandon
- Donald Quinn
- Donna Percy
- Doris Franco-Vitteri
- Douglas S. Denham
- E. Javier Pretell Alva
- Edgar Garcia
- Edith Swann
- Eduardo Gabriel Vázquez Saldaña
- Edward C. Jones-López
- Edward E. Walsh
- Edward Ellerbeck
- Edward M. Tavel Jr.
- Elham Ghadishah
- Elie Gharib
- Elisa Swieboda
- Elissa Malkin
- Elizabeth Barranco-Santana
- Elizabeth Bennett
- Elizabeth Bruce
- Elizabeth Danford
- Elizabeth Duke
- Elizabeth E. Robison
- Elizabeth Everette
- Elizabeth Formentini
- Elizabeth Hammershaimb
- Elizabeth Parker
- Elizabeth Secord
- Ellie Carmody
- Elliot DeHaan
- Elwaleed Elnagar
- Emily Degan
- Emily Oppenheim
- Emma Bainbridge
- Emmanuel B. Walter
- Eneyda Giuvanela Llerena Zegarra
- Enrique Ocaña
- Eric A. Meyerowitz
- Eric Bravo
- Eric McGrath
- Eric Miller
- Erica Herc
- Erica Johnson
- Erica Osmundsen
- Erica Sanchez
- Erika A. Cutz
- Erika Mendoza
- Erin A. Goecker
- Erin Cooksey
- Erin Coston
- Ernesto Delgado
- Esther L. Harmon
- Esther S. Huffine
- Evan C. Ewers
- Evan J. Anderson
- Evelyn Hall
- Evelyn Lomasney
- Evelyn Quevedo
- Fan Yang
- Farah Irani
- Farhan Siddiqui
- Fernanda Morales
- Fernando L. Merino
- Filip Dubovsky
- Flora Castellino
- Florence Momplaisir
- Florida Aristy
- Frances Downing
- Frank James
- Frank S. Eder
- Frank Struyf
- Fred E. Newton
- Frederick Raiser III
- Fredric Santiago
- Gail Broder
- Gary Albert
- Gary Headden
- Gary Horwith
- Gary Luckasen
- Gary Simon
- Gayle D. Hennekes
- Genevieve Beninati
- Genevieve Iwuala
- George H. Bauer Jr.
- George H. Freeman
- Georgette Ebuh
- Georgettea Geuss
- Gerald Kelty
- Germán Áñez
- Getahun Abate
- Gina Rivero
- Glenda E. Gray
- Glenn Wortman
- Gowdhami Mohan
- Grant Ellsworth
- Grant Geiger
- Greg Hachigian
- Greg Wilson
- Gregg H. Lucksinger
- Gregory C. Utz
- Gregory Holt
- Gregory J. Feldman
- Gregory M. Glenn
- Gregory M. Gottschlich
- Griet Van Roey
- Guillermo Miguel Ruiz-Palacios
- Gysella Muniz
- Hala Webster
- Hana M. El Sahly
- Hanh Chu
- Hanh Chu
- Hannah Catan
- Hannah Harrington
- Hannah Nevarez
- Haoua Dunbar
- Hayes Williams
- Heather Rattenbury-Shaw
- Henry Peralta
- Hilario Alvarado
- Hillary Dunlevy
- Holli Hamilton
- Holly E. Janes
- Hong V. Tieu
- Horacio Marafioti
- Howard I. Schwartz
- Howard Schwartz
- Hussain Malbari
- Huub G. Gelderblom
- Hyman Scott
- Ian De Proost
- Ian Frank
- Ian Hirsch
- Iksung Cho
- Ilse Van Dromme
- Insiya Valika
- Irene Graham
- Irene McKnight
- Iris García
- Isaac Thomsen
- Isabel Pereira
- Issac Pena-Renteria
- Jack Stapleton
- Jacob Coleman
- Jacqueline Miller
- Jacqueline Muenzner
- Jaleh Ostovar
- Jaleh Ostovar
- Jalima Quintero
- James Andersen
- James Fry
- James G. Kublin
- James H. Conway
- James Longe
- James Lovell
- James N. Goldenberg
- James Peacock
- James Ramsey
- James T. Peterson
- James W. Hurst
- James Walker
- James Zhou
- Jamie Ackerman
- Jamshid Saleh
- Jan Patterson
- Janet Garvey
- Janet Hill
- Janet Mendez
- Janet Otto
- Janeth Pacheco-Flores
- Janice Suyehira
- Janine Maenza
- Jarek Juraszek
- Jason F. Okulicz
- Jason Milligan
- Jay Meyer
- Jayasree Krishnankutty
- Jeanne Blevins
- Jeb Andrews
- Jeff Kingsley
- Jeffrey A. Henderson
- Jeffrey Adelglass
- Jeffrey Dugas Sr.
- Jeffrey Klein
- Jeffrey M. Jacobson
- Jeffrey Meier
- Jeffrey Rosen
- Jeffrey S. Overcash
- Jeffrey Thessing
- Jeffry Jacqmein
- Jenina Garcia
- Jennie Johnson
- Jennifer A. Johnson
- Jennifer A. Whitaker
- Jennifer Bashour
- Jennifer Berry
- Jennifer Chang
- Jennifer Foley
- Jennifer Knishinsky
- Jennifer Knowles
- Jennifer L. Dong
- Jennifer McCarter
- Jennifer Petts
- Jennifer Schwartz
- Jennifer Winbigler
- Jenny Hendriks
- Jerald Sadoff
- Jeremy Ackermann
- Jeremy Brown
- Jerome Custers
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- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Recommended from our members
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
- Bances Karla Beatriz Tafur
- Baron Mira
- Barranco-Santana Elizabeth
- Bartilucci Darlene
- Bashour Jennifer
- Batteiger Teresa A.
- Baudelaire Clarisse
- Bazan Jose A.
- Becerra Maria G.
- Becker Teresa
- Beckmann David
- Bedimo Roger J.
- Belhorn Linda R.
- Benavides Alfredo Gilberto Guerreros
- Beninati Genevieve
- Benitez Jorge A.
- Bennett Annette R.
- Bennett Elizabeth
- Beresnev Tatiana
- Berman Megan
- Bermudez Maria I.
- Bernard Marcia
- Bernstein David I.
- Berry Andrea
- Berry Jennifer
- Berthaud Vladimir
- Bialobok Kristin
- Billings Joanne L.
- Bittner Zachary
- Blevins Jeanne
- Blumenthal Jill
- Boas Rebecca
- Bocchini Joseph
- Bold Tyler D.
- Bondell Alison
- Bondy Paul
- Borger Judith
- Borgetti Scott
- Boscia Joseph
- Boswell Dean M.
- Bourgeois Tana
- Bowers Maggie
- Bradley Paul S.
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- Choquette Karin
- Chouteau R. Michelle
- Chow Brian D.W.
- Choza Laura Julia Camacho
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- Christensen Shane G.
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- Chughtai Waseem
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- Rodman Shannon
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- Villegas Marysol
- Vingerhoets Johan
- Vogler Mary
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- Vrbicky Keith W.
- Wahlin Tami
- Wakefield Paul H.
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- Walker James
- Walker Shannon
- Walsh Edward E.
- Walsh Mary C.
- Walsh Stephen R.
- Walsh Stephen R.
- Walter Emmanuel B.
- Walters Ayanna
- Wang Tina
- Warden Ashley
- Waters Michael
- Watkins Breanz
- Webb Angella
- Webster Hala
- Weidler Jessica L.
- Weiss Thomas
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- Wendell Lewis III
- Wendrow Andrea
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- Whatley Jordan L.
- Whitaker Jennifer A.
- White Jewel J.
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- Wijewardane Priyantha N.
- Wilkin Timothy
- Wilkinson Bethanie
- William S. Davis Jr
- Williams Barton G.
- Williams Hayes
- Williams Samantha
- Wilson Christine
- Wilson Clint
- Wilson Greg
- Wilson Natasha
- Winbigler Jennifer
- Winkle Peter J.
- Winokur Patricia L.
- Witbeck John
- Wohl David
- Woo Wayne
- Woodside Leana
- Wortman Glenn
- Wu Yi H.
- Wylie Paul E.
- Yang Fan
- Yang Kinara S.
- Yoon Anelgine C.
- York Jill
- Young Cheryl
- Yu Chenchen
- Yusin Joseph
- Zapata Luz
- Zash Rebecca
- Zegarra Eneyda Giuvanela Llerena
- Zemanek Arthur L.
- Zenlea Kate
- Zepeda Karla
- Zervos Marcus J.
- Zhai Nan
- Zhang Kevin
- Zhou James
- Zimmer Andrea
- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Reduction of cardiac imaging tests during the COVID-19 pandemic: The case of Italy. Findings from the IAEA Non-invasive Cardiology Protocol Survey on COVID-19 (INCAPS COVID)
- Author
- Abdelkader Medjahedi
- Adam Bernheim
- Adel Allam
- Adelina Sanches
- Aditya Sood
- Adna Lima
- Adolfo Facello
- Adriana Puente Barragan
- Adwait Trivedi
- Afonso Shiozaki
- Agha Haider
- Agnès Pasquet
- Ahmad Mansy
- Ahmad Ozair
- Ahmad Slim
- Ahmed Asfour
- Ahmed Ibrahim
- Ahmed Kandeel
- Ahmed Tawakol
- Aikaterini Archontaki
- Alan Goldberg
- Alastair Moss
- Alberico Del Torto
- Albert Flotats
- Albert T
- Alberto Cadena
- Alberto Cossu
- Alberto Cuocolo
- Aldo Carnevale
- Alejandra Marquez
- Alejandro Becerril González-Montecinos
- Alejandro Canderoli
- Alejandro De La Vega
- Alejandro Deviggiano
- Alejandro Horacio Meretta
- Alejandro Radzinschi
- Alejandro Zuluaga Costa Rica: Isabel Berrocal Gamboa
- Alessia Gimelli
- Alex Frenkel
- Alexander Kokov
- Alexander Pitman
- Alexander Sasse
- Alexandra Smith
- Alexia Farrugia
- Alfonso Waller
- Alfredo Astesiano
- Alfredo Rodrigues
- Alia Hassan
- Alicia Camarero
- Alistair Gummow
- Alix Juillet de Saint Lager Lucas
- Allan Johansen
- Alvin Quinon
- Amalia Peix
- Amanda Marn
- Ambedhkar Shantaram Naojee Mexico: Erick Alexanderson-Rosas
- Amelia Jimenez-Heffernan
- Ami Iskandrian
- Amit Patel
- Amit Pursnani
- Ana Sevilla
- Anand Gaikwad
- Anastasia Oikonomou
- Anatoly Karalkin
- Anda Bularga
- Anders Thomassen
- Anders Tjellaug Bråten Oman: Humoud Al Dhuhli
- Andor Glaudemans
- Andrea Astesiano
- Andrea Bruno
- Andrea De Lorenzo
- Andres Vasquez
- Andressa Borges
- Andrew Choi
- Andrew Kelion
- Andrew Taylor
- Andrew To
- Andrés Preciado-Anaya
- Angela Burandt
- Angela Byrne
- Angela Gaudiano
- Anggoro Praja Mukti
- Anibal Mele
- Anjori Dunbar
- Anri Inaki
- Ante Punda Cuba: Juan Felipe Batista
- Anthony Murray
- Anthony Samuel Mauritius: Mohammad Aaftaab Allarakha
- Anthony Upton
- Antonella Stefanelli
- Antonio Cabrera
- Antonio Calderón Moncayo
- Antonio Calderón Moncayo
- Antonio Ferreira Qatar: Ghulam Syed Republic of Ireland: Samer Arnous
- Anupama Kottam
- Anxo Martinez de Alegria
- Aparna Deshpande
- Aparna Irodi
- Armando Ugo Cavallo
- Arthur Scholte
- Arturo Romero Acuña
- Arve Jørgensen
- Aryeh Shalev Jamaica: Dainia Baugh
- Asbjørn Scholtens
- Asela Barroso
- Ashok Gangasandra Basavaraj
- Ashwani Sood
- Atsutaka Okizaki
- Atul Verma Indonesia: Erwin Affandi
- Augusto Almeida
- Aulia Huda
- Austin Robinson
- Axel Rominger
- Ayreen Cordero
- Azhar Khokhar
- Balint Szilveszter
- Barbara Nardi
- Barry Elison
- Bart De Boeck
- Basuki Hidayat
- Benjamin Chow
- Benjamin Hudson
- Bernardo Spiro
- Better N.
- Bettina Tecson
- Bhagwant Rai Mittal
- Bhanupriya Singh
- Bijoy Rajbanshi Netherlands: Peter Barneveld
- Bin Lu
- Bjarne Linde Norgaard
- Bo Zerahn Dominican Republic: Alfredo Perez Ecuador: Giovanni Alejandro Escorza Velez
- Brian Abbott
- Brian Ghoshhajra
- Brian Goldner
- Brian Pomerantz
- Bruce Decter
- Bruce Goodwin
- Bruno Castro
- Bruno Ghini
- Bruno Strada
- Caiying Li
- Calum Young Nicaragua: Teresa Cuadra
- Cameron Foster
- Candace Candela
- Carlo Liguori
- Carlos Anselmi
- Carlos Caicedo
- Carlos Collaud
- Carlos Collaud
- Carlos Eduardo Soares
- Carlos Novoa
- Carlos Rodrigues
- Carmen Concha
- Carolina Bas Norton
- Caroline M. Van De Heyning Bolivia: Raúl Araujo Ríos Bosnia - Herzegovina: Valentina Soldat-Stankovic
- Carolyn Hawkins
- Cerci R.
- Cesar Lovera
- Cesar Nomura
- Cesar Rodríguez
- Chae Moon Hong
- Chanan Moffitt
- Chandraguptha Udugama Sweden: Magnus Simonsson Switzerland: Hatem Alkadhi
- Chang Kyeong Namgung
- Charles Chao
- Charles Peebles
- Chen Low
- Chetan Patel
- Chibuzo Madu
- Chimura Misato Chimura
- Chris Ellis
- Chris Johnson
- Christel H. Kamani
- Christian Hamilton-Craig
- Christian Michael Pawhay
- Christina Fragkaki
- Christine Jellis
- Christoph Gräni
- Christopher Occleshaw
- Christopher Rofe
- Claudia Cortes
- Claudia Jaimes
- Claudia T. Gutierrez Villamil
- Claudio Marcassa
- Claudio Pereyra Sueldo
- Claudiu Adrian Stan Russian Federation: Alexey Ansheles
- Cláudio Tinoco Mesquita
- Connor Saunders
- Conor Meehan
- Corrado Cittanti
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- Zorana Mrsic
- Óscar Ulises Preciado-Gutiérrez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: In early 2020, COVID-19 massively hit Italy, earlier and harder than any other European country. This caused a series of strict containment measures, aimed at blocking the spread of the pandemic. Healthcare delivery was also affected when resources were diverted towards care of COVID-19 patients, including intensive care wards. Aim of the study: The aim is assessing the impact of COVID-19 on cardiac imaging in Italy, compare to the Rest of Europe (RoE) and the World (RoW). Methods: A global survey was conducted in May–June 2020 worldwide, through a questionnaire distributed online. The survey covered three periods: March and April 2020, and March 2019. Data from 52 Italian centres, a subset of the 909 participating centres from 108 countries, were analyzed. Results: In Italy, volumes decreased by 67% in March 2020, compared to March 2019, as opposed to a significantly lower decrease (p < 0.001) in RoE and RoW (41% and 40%, respectively). A further decrease from March 2020 to April 2020 summed up to 76% for the North, 77% for the Centre and 86% for the South. When compared to the RoE and RoW, this further decrease from March 2020 to April 2020 in Italy was significantly less (p = 0.005), most likely reflecting the earlier effects of the containment measures in Italy, taken earlier than anywhere else in the West. Conclusions: The COVID-19 pandemic massively hit Italy and caused a disruption of healthcare services, including cardiac imaging studies. This raises concern about the medium- and long-term consequences for the high number of patients who were denied timely diagnoses and the subsequent lifesaving therapies and procedures
International Impact of COVID-19 on the Diagnosis of Heart Disease
- Author
- Abdelkader Medjahedi
- Adam Bernheim
- Adelina Sanches
- Aditya Sood
- Adna Lima
- Adolfo Facello
- Adriana Puente Barragan
- Adwait Trivedi
- Afonso Shiozaki
- Afroza Akhter
- Agha Haider
- Agnès Pasquet
- Ahmad Mansy
- Ahmad Ozair
- Ahmad Slim
- Ahmed Asfour
- Ahmed Ibrahim
- Ahmed Kandeel
- Aikaterini Archontaki
- Alan Goldberg
- Alastair Moss
- Alberico Del Torto
- Albert Flotats
- Albert T Ahmed Tawakol
- Alberto Cadena
- Alberto Cossu
- Alberto Cuocolo
- Aldo Carnevale
- Alejandra Marquez
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- Tiago Senra
- Tien Chang
- Tiffany Chen
- Timothy Fairbairn
- Tolulope Ayodele
- Tomoaki Nakata
- Tomohisa Fukunaga
- Tonci Batinic
- Tong Zhang
- Tony Fuisz
- Tony Mcrae
- Tony Stanton
- Toshiaki Kadokami
- U Joseph Schoepf
- Ulises González
- Umberto Conti
- Vaclav Engelmann
- Valentina Soldat-Stankovic
- Valtteri Uusitalo
- Vania Naue
- Vania Tacher
- Velipekka Kokkonen
- Venjamin Majstorov
- Venkatesh Murthy
- Venkateshwar Polsani
- Veronica Della Tommasina
- Veronique Roelants
- Victar Hsieh
- Victor Hasbani
- Victor Jäger
- Victor Wayne
- Vijay Sai Chowdekar
- Vijay Solanki
- Vikas Tandon
- Vikas Verma
- Viktor Persic
- Viktor Pospelov
- Villines T. C.
- Vincent Habouzit
- Vincent Peter Magboo
- Vincenzo Russo
- Vinícius Kameoka
- Violeta Cortés
- Virgil Chan
- Virginia Peiro
- Virginia Pubul-Nuñez
- Vitola J. V.
- Vivek Bhat
- Viviana Frantellizzi
- Vladimír Kincl
- Volodymyr Pliatsek
- Vsevolod Milyevich Gulyaev
- Warren Moore
- William Duvall
- William Topping
- William Van Gaal
- Williams M. C.
- Wilson Furlan Alves
- Wladimir Yurievich Ussov
- Won Jun Kang
- Woon Chong
- Wu Yin
- Xiaoli Zhang
- Ximing Wang
- Xu Dai
- Xuan Canh Nguyen
- Yamile Marcos Gutierrez
- Yamile Marcos Gutierrez
- Yang Hou
- Yao Lu
- Yariela Herrera
- Yaroslav Kmetyuk
- Yasmin Hamirani
- Yasushi Wakabayashi
- Yasutaka Ichikawa
- Yasutoshi Ohta
- Yasuyo Taniguchi
- Yetunde Onimode
- Yiannis Chatzizisis
- Yifan Wang
- Yining Wang
- Yiyan Liu
- Yoav Arnson
- Yoichi Otomi
- Yong Hyu Jeong
- Yong-Gao Zhang
- Yoshimitsu Fukushima
- Yoshinobu Suwa
- Youdaline Theng
- Young So
- Youyou Yang
- Zabah Jawa
- Zerida Muyinda
- Zhao-Qian Wang
- Zhifang Wu
- Zhuoran Xu
- Zorana Mrsic
- Óscar Ulises Preciado-Gutiérrez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: The coronavirus disease 2019 (COVID-19) pandemic has adversely affected diagnosis and treatment of noncommunicable diseases. Its effects on delivery of diagnostic care for cardiovascular disease, which remains the leading cause of death worldwide, have not been quantified. Objectives: The study sought to assess COVID-19's impact on global cardiovascular diagnostic procedural volumes and safety practices. Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations in cardiovascular procedure volumes and safety practices resulting from COVID-19. Noninvasive and invasive cardiac testing volumes were obtained from participating sites for March and April 2020 and compared with those from March 2019. Availability of personal protective equipment and pandemic-related testing practice changes were ascertained. Results: Surveys were submitted from 909 inpatient and outpatient centers performing cardiac diagnostic procedures, in 108 countries. Procedure volumes decreased 42% from March 2019 to March 2020, and 64% from March 2019 to April 2020. Transthoracic echocardiography decreased by 59%, transesophageal echocardiography 76%, and stress tests 78%, which varied between stress modalities. Coronary angiography (invasive or computed tomography) decreased 55% (p < 0.001 for each procedure). In multivariable regression, significantly greater reduction in procedures occurred for centers in countries with lower gross domestic product. Location in a low-income and lower–middle-income country was associated with an additional 22% reduction in cardiac procedures and less availability of personal protective equipment and telehealth. Conclusions: COVID-19 was associated with a significant and abrupt reduction in cardiovascular diagnostic testing across the globe, especially affecting the world's economically challenged. Further study of cardiovascular outcomes and COVID-19–related changes in care delivery is warranted
Impact of COVID-19 on Diagnostic Cardiac Procedural Volume in Oceania: The IAEA Non-Invasive Cardiology Protocol Survey on COVID-19 (INCAPS COVID)
- Author
- Abdelkader Medjahedi
- Adam Bernheim
- Adel Allam
- Adelina Sanches
- Aditya Sood
- Adna Lima
- Adolfo Facello
- Adriana Puente Barragan
- Adwait Trivedi
- Afghanistan: Mohammad Nawaz Nasery Albania: Artan Goda
- Afonso Shiozaki
- Agha Haider
- Agnès Pasquet
- Ahmad Mansy
- Ahmad Ozair
- Ahmad Slim
- Ahmed Asfour
- Ahmed Ibrahim
- Ahmed Kandeel
- Ahmed Tawakol
- Aikaterini Archontaki
- Alan Goldberg
- Alastair Moss
- Alberico Del Torto
- Albert Flotats
- Albert T
- Alberto Cadena
- Alberto Cossu
- Alberto Cuocolo
- Aldo Carnevale
- Alejandra Marquez
- Alejandro Becerril González-Montecinos
- Alejandro Canderoli
- Alejandro De La Vega
- Alejandro Deviggiano
- Alejandro Horacio Meretta
- Alejandro Radzinschi
- Alejandro Zuluaga Costa Rica: Isabel Berrocal Gamboa
- Alessia Gimelli
- Alex Frenkel
- Alexander Kokov
- Alexander Pitman
- Alexander Sasse
- Alexandra Smith
- Alexia Farrugia
- Alfonso Waller
- Alfredo Astesiano
- Alfredo Rodrigues
- Alia Hassan
- Alicia Camarero
- Alistair Gummow
- Alix Juillet de Saint Lager Lucas
- Allan Johansen
- Alvin Quinon
- Amalia Peix
- Amanda Marn
- Ambedhkar Shantaram Naojee Mexico: Erick Alexanderson-Rosas
- Amelia Jimenez-Heffernan
- Ami Iskandrian
- Amit Patel
- Amit Pursnani
- Ana Sevilla
- Anand Gaikwad
- Anastasia Oikonomou
- Anatoly Karalkin
- Anda Bularga
- Anders Thomassen
- Anders Tjellaug Bråten Oman: Humoud Al Dhuhli
- Andor Glaudemans
- Andrea Astesiano
- Andrea Bruno
- Andrea De Lorenzo
- Andres Vasquez
- Andressa Borges
- Andrew Choi
- Andrew Kelion
- Andrew Taylor
- Andrew To
- Andrés Preciado-Anaya
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- Dong Li
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- Rajaram Poludasu
- Rajesh Burgul
- Rajesh Janardhanan
- Raluca Mititelu
- Rami Doukky
- Ramkumar Sekar
- Randall Thompson
- Randazzo M.
- Raul Cabrejas
- Ravi Patel
- Raymond Russell
- Rayner Menéndez
- Rebecca Schofield
- Rene Barette
- Renée Bullock-Palmer
- Rexhep Durmo
- Ria Bester
- Ria Garg
- Ricardo Castro
- Ricardo Geronazzo
- Ricardo Machado e Silva
- Ricardo Rocha
- Ricardo Ruano Perez
- Riccardo Faletti
- Riccardo Laudicella
- Riccardo Liga
- Richard R. Bayer
- Riemer Slart
- Rishi Bhargava
- Robert Greenough
- Robert Hendel
- Robert Manka
- Robert Miller
- Roberta Araújo
- Roberta Casoni
- Roberto Boni
- Roberto Cury
- Roberto Dantas
- Roberto Nicolas Aguero
- Roberto Nolasco
- Roberto Sciagrà
- Roberto Waltrick
- Robson De Macedo Filho
- Rodolfo Ferrando
- Rodrigo Biancardi
- Rodrigo Moreno-Reyes
- Rodrigo Rizzo Nogueira Ramos
- Rohan Poulter
- Rolf Steffensen
- Romina Lorena Romero
- Ron Blankstein
- Ronaldo Lima
- Ronny Ralf Buechel
- Rosco Gore
- Roslyn Francis
- Ross Keenan
- Roxana Campisi
- Ruben Emilio Enriquez
- Rubén Leta
- Russell Bull
- Ryan Paul
- Ryan Prentice
- Ryo Nakazato
- Ryota Morimoto
- Sabbrina Bezerra
- Sabha Bhatti
- Sabina Pulizzi
- Said Atyani
- Sakata Yasushi Sakata
- Salah Bouyoucef
- Salvatore Ialuna
- Sameh Kaffas
- Samir Shah
- Samuel Burg
- Samuel Unzek
- Sandra Abramson
- Sandra Ayala
- Sandra Gracia-López
- Sandra Graciela Rosales Uvera
- Sandra Yost
- Sang-Geon Cho
- Santosh Singh
- Sara Pacella
- Sara Ranser
- Sara Santana
- Sara Taleb Myanmar: Khin Pa Pa Myo
- Satoshi Isobe
- Satoshi Okayama
- Saurav Chatterjee
- Scott Jerome
- Sean Blue
- Sebastian Perez Ascani
- Sergio Baldari
- Seth Uretsky
- Seyed Rasoul Zakavi Israel: Eed Abu Zaid
- Shady Abohashem
- Shamil Morayati
- Shankar Vamadevan
- Shantanu Sengupta
- Sharon Gomez
- Shashank Jain
- Shaw Hua (Anthony) Kueh
- Shaw L. J.
- Shawn Ullery
- Shazia Fatima
- Sherif Nabil
- Shigeki Nagamachi
- Shinichiro Fujimoto
- Shinichiro Kumita
- Shinichiro Yamada
- Shinya Shiraishi
- Shinya Yamazaki
- Shivani Patel
- Sigelinda Sandoval
- Signe Helene Forsdahl
- Sijin Li
- Silvia Carames
- Silvia Siu
- Silvia Teresa De Maria
- Simone Brandão
- Sinisa Stankovic Brazil: Maria Helena Albernaz Siqueira
- Siroos Mirzaei
- Sofia Chatziioannou
- Sofia Haider
- Son Hong Mai
- Sonexay Rajvong Latvia: Artem Kalinin
- Sonia Simona Traverzo
- Sonia Traverso
- Sophia Koukouraki
- Sorin Danciu
- Srikanth Vallurupalli
- Stefan Pool
- Stefania Zoboli Jamaica: Dainia Baugh
- Stephan Probst
- Stephen Bloom
- Stephen Cheung
- Stephen E Matis
- Stephen Horgan
- Steve Leung
- Steven H Lee
- Steven Shayani
- Steven Sigman
- Steven Unger
- Stuart More
- Su Jin Jang
- Subhani Okarvi Serbia: Dragana Sobic Saranovic Singapore: Felix Keng
- Subodh Joshi
- Sudhir Saxena
- Sujata Shanbhag
- Sujith Seneviratne
- Sukriti Kumar
- Summanther Kaviratne
- Suresh Ramamurti
- Susana Molteni
- Susana Zeffiro Armenia: Mari Sakanyan Australia: Scott Beuzeville
- Svetlana Agranovich
- Svetlana Sazonova
- Sze Mun Mak
- Søren Hess
- Tadhg Gleeson
- Taghreed Ahmed
- Taimur Abbasi
- Tairkhan Dautov Kenya: Khalid Makhdomi
- Takao Kato
- Takashi Kudo
- Takashi Norikane
- Tanyaluck Thientunyakit Tunisia: Ali Sellem Turkey: Kemal Metin Kir
- Tao Li
- Tapan Patel
- Tara Torbet
- Tarek Al-Abboud
- Tatjana Trifonova
- Tatsuya Yoneyama Jordan: Mohammad Rawashdeh Kazakhstan: Daultai Batyrkhanov
- Teerapon Premprabha
- Teresa Massardo
- Thiago Ferreira De Souza
- Thomas Biggans
- Thomas Hartley
- Thomas Porter
- Thomas Semple
- Tiago Magalhães
- Tiago Senra
- Tien Chang
- Tiffany Chen
- Timothy Fairbairn
- Tomoaki Nakata
- Tomohisa Fukunaga
- Tonci Batinic
- Tong Zhang
- Tony Fuisz
- Tony Mcrae
- Tony Stanton
- Toshiaki Kadokami
- U. Joseph Schoepf
- Ulises González
- Umberto Conti
- Valtteri Uusitalo France: Matthieu Bailly
- Van Pelt N.
- Vania Naue
- Vania Tacher Germany: Roman P. Schneider Ghana: Harold Ayetey Greece: George Angelidis
- Velipekka Kokkonen
- Venkatesh Murthy
- Venkateshwar Polsani
- Veronica Della Tommasina
- Veronique Roelants
- Victar Hsieh
- Victor Hasbani
- Victor Jäger
- Victor Wayne
- Vijay Sai Chowdekar
- Vijay Solanki
- Vikas Tandon
- Vikas Verma
- Viktor Persic
- Viktor Pospelov
- Villines T. C.
- Vincent Habouzit
- Vincent Peter Magboo
- Vincenzo Russo
- Vinícius Kameoka
- Violeta Cortés
- Virgil Chan
- Virginia Peiro
- Virginia Pubul-Nuñez
- Vitola J. V.
- Vivek Bhat
- Viviana Frantellizzi
- Vladimir Sergienko
- Vladimír Kincl
- Volodymyr Pliatsek
- Vsevolod Milyevich Gulyaev
- Warren Moore
- William Duvall
- William Topping
- William Van Gaal
- Williams M. C.
- Wilson Furlan Alves
- Wladimir Yurievich Ussov
- Won Jun Kang
- Woon Chong
- Wu Yin
- Xiaoli Zhang
- Ximing Wang
- Xu Dai
- Xuan Canh Nguyen
- Yamile Marcos Gutierrez
- Yamile Marcos Gutierrez
- Yang Hou
- Yasmin Hamirani
- Yasushi Wakabayashi
- Yasutaka Ichikawa
- Yasutoshi Ohta
- Yasuyo Taniguchi
- Yetunde Onimode Norway: Elen Efros-Monsen
- Yiannis Chatzizisis
- Yifan Wang
- Yining Wang
- Yiyan Liu
- Yoav Arnson
- Yoichi Otomi
- Yong Hyu Jeong
- Yong-Gao Zhang
- Yoshimitsu Fukushima
- Yoshinobu Suwa
- Young So
- Younger J.
- Youyou Yang
- Zabah Jawa
- Zerida Muyinda Ukraine: Yaroslav Kmetyuk
- Zhao-Qian Wang
- Zhifang Wu
- Zorana Mrsic
- Óscar Ulises Preciado-Gutiérrez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: The INCAPS COVID Oceania study aimed to assess the impact caused by the COVID-19 pandemic on cardiac procedure volume provided in the Oceania region. Methods: A retrospective survey was performed comparing procedure volumes within March 2019 (pre-COVID-19) with April 2020 (during first wave of COVID-19 pandemic). Sixty-three (63) health care facilities within Oceania that perform cardiac diagnostic procedures were surveyed, including a mixture of metropolitan and regional, hospital and outpatient, public and private sites, and 846 facilities outside of Oceania. The percentage change in procedure volume was measured between March 2019 and April 2020, compared by test type and by facility. Results: In Oceania, the total cardiac diagnostic procedure volume was reduced by 52.2% from March 2019 to April 2020, compared to a reduction of 75.9% seen in the rest of the world (p<0.001). Within Oceania sites, this reduction varied significantly between procedure types, but not between types of health care facility. All procedure types (other than stress cardiac magnetic resonance [CMR] and positron emission tomography [PET]) saw significant reductions in volume over this time period (p<0.001). In Oceania, transthoracic echocardiography (TTE) decreased by 51.6%, transoesophageal echocardiography (TOE) by 74.0%, and stress tests by 65% overall, which was more pronounced for stress electrocardiograph (ECG) (81.8%) and stress echocardiography (76.7%) compared to stress single-photon emission computerised tomography (SPECT) (44.3%). Invasive coronary angiography decreased by 36.7% in Oceania. Conclusion: A significant reduction in cardiac diagnostic procedure volume was seen across all facility types in Oceania and was likely a function of recommendations from cardiac societies and directives from government to minimise spread of COVID-19 amongst patients and staff. Longer term evaluation is important to assess for negative patient outcomes which may relate to deferral of usual models of care within cardiology