Grill & Vinos

El proyecto Grill & Vinos, es una propuesta de negocio de plataforma ecommerce que consiste en brindar un servicio de ventas de productos premium de parrillas; en el cual los usuarios puedan encontrar fácilmente todos los productos e insumos necesarios para preparar una parrillada de calidad Premium con quesos variados, carnes de diversos cortes, vinos de la más alta calidad y cervezas artesanales. Por ello, busca satisfacer las necesidades de personas que tienen un estilo de vida moderno que prefieren cuidar de su salud y consumir productos que cumplan con altos estándares de cálida y rapidez. Grill & Vinos dispone de un sistema GPS de rastreo que se realiza en tiempo real para mayor seguridad para el servicio; también, cuentan con alianzas estratégicas de proveedores líderes en el mercado parrillero; por lo que, los convierte en ser un proyecto nuevo en el mercado diferenciándose de otros. Grill & Vinos determina un servicio totalmente personalizado y con un equipo altamente capacitado con experiencia en cada una de las áreas del proyecto con el objetivo de brindar un servicio de calidad. La propuesta de negocio actual cuenta con una tasa de conversión del 29.41% obtenido por medio de la landing page, acreditando su éxito. En el lado financiero, se mantienen positivo con un WACC de 12.27%. Por lo tanto, se espera para el primer año un ingreso total por venta de S/. 895,610.00 y su proyección a cinco años nos da un monto total de S/. 1614,645.54 sin IGV.The Grill & Vinos project is a business proposal for an electronic commerce platform that consists of providing a sales service for premium barbecue products; in which users can easily find all the products and supplies necessary to prepare a Premium quality barbecue with assorted cheeses, meats of various cuts, wines of the highest quality and craft beers. Therefore, it seeks to satisfy the needs of people who have a modern lifestyle who prefer to take care of their health and consume products that meet high standards of warmth and speed. Grill & Vinos has a GPS tracking system that is carried out in real time for greater security for the service; They also have strategic alliances with leading suppliers in the barbecue market; therefore, it becomes a new project on the market, differentiating itself from others. Grill & Vinos determines a totally personalized service with a highly trained team with experience in each of the project areas with the aim of providing a quality service. The current business proposal has a conversion rate of 29.41% obtained through the landing page, proving its success. On the financial side, they remain positive with a WACC of 12.27%. Therefore, a total income from sale of S/. 895,610.00 and its five-year projection gives us a total amount of S/. 1614,645.54 without VAT.Trabajo de investigació

Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions

Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH) in a cohort of 1045 untreated MBL/CLL patients. In all, 99/1045 (9.5%) patients displayed a CK. Despite ATM and TP53 deletions were more common in CK (25% vs 7%; P < 0.001; 40% vs 5%; P < 0.001, respectively), only 44% (40/90) patients with TP53 deletions showed a CK. CK group showed a significant higher two-year cumulative incidence of treatment (48% vs 20%; P < 0.001), as well as a shorter overall survival (OS) (79 mo vs not reached; P < 0.001). When patients were categorized regarding CK and HR-FISH, those with both characteristics showed the worst median OS (52 mo) being clearly distinct from those non-CK and non-HR-FISH (median not reached), but no significant differences were detected between cases with only CK or HR-FISH. Both CK and TP53 deletion remained statistically significant in the multivariate analysis for OS. In conclusion, CK group is globally associated with advanced disease and poor prognostic markers. Further investigation in larger cohorts with CK lacking HR-FISH is needed to elucidate which mechanisms underlie the poor outcome of this subgrou

Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions

Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH) in a cohort of 1045 untreated MBL/CLL patients. In all, 99/1045 (9.5%) patients displayed a CK. Despite ATM and TP53 deletions were more common in CK (25% vs 7%; P < 0.001; 40% vs 5%; P < 0.001, respectively), only 44% (40/90) patients with TP53 deletions showed a CK. CK group showed a significant higher two-year cumulative incidence of treatment (48% vs 20%; P < 0.001), as well as a shorter overall survival (OS) (79 mo vs not reached; P < 0.001). When patients were categorized regarding CK and HR-FISH, those with both characteristics showed the worst median OS (52 mo) being clearly distinct from those non-CK and non-HR-FISH (median not reached), but no significant differences were detected between cases with only CK or HR-FISH. Both CK and TP53 deletion remained statistically significant in the multivariate analysis for OS. In conclusion, CK group is globally associated with advanced disease and poor prognostic markers. Further investigation in larger cohorts with CK lacking HR-FISH is needed to elucidate which mechanisms underlie the poor outcome of this subgroup