El papel del cooperativismo en el turismo rural de la Comunidad Valenciana

This study considers rural tourism an activity that is playing an important role in the local development of many inland shires, with notable future potential both as a means of complementing agricultural income and as a way to create employment in disadvantaged inland areas. The co-operative philosophy is presented as ideal for getting these activities underway; whether under the agricultural co-operative format –already widely known in rural areas-; or in the form of associated work co-operatives or community land exploitation. The article shows the experiences in this field and this business format in the Valencia Autonomous Region, explaining the main defining features.Rural tourism, agricultural co-operatives, associated work co-operatives, local development, Valencia Region.

Desarrollo y evaluación de la competencia trabajo en equipo en el grado en Gestión Turística (Primera Fase)

[EN] The main purpose of this project is to design, evaluate and implement a methodology that allows us to properly develop the competence of Teamwork in the Degree of Tourism Management (GGT) taught at the Gandia Campus of the Universitat Polit`ecnica de Val`encia (UPV). In the preliminary phase of the project, which is presented in this paper, we describe the initial experiences developed during 2013-2014 by some teachers who teach in the GGT. In this project, we have collaborated with researchers from the GTI-IA1 group of the UPV that have developed a tool for automatic group formation based on the Belbin’s Roles Taxonomy. The methodology that we are developing takes as starting point data from the Belbin profiles of students, obtained through surveys conducted by students at the end of a given task in a particular subject. This information is used to establish new work teams to address a new task in the same or in other subjects. The methodology is evaluated through surveys in which students express their satisfaction with respect to the performance of the team after every task. The initial results show that the line we are following seems to be suitable for the development of the teamwork competence. We are currently working on more advanced stages within the framework of a project of the UPV PIME, in order to improve and complete the implementation of this methodology.[ES] La finalidad principal de este proyecto es diseñar, evaluar e implementar una metodología que nos permita desarrollar adecuadamente la competencia de Trabajo en Equipo en el Grado de Gestión Turística (GGT) que se imparte en la Escuela Politécnica Superior de Gandía (EPSG) de la Universitat Politècnica de València (UPV). En la fase preliminar del proyecto, que es la que presentamos en este artículo, describimos las experiencias iniciales desarrolladas durante el curso 2013-2014 por algunos profesores que impartimos clases en el GGT. Para realizar este trabajo hemos colaborado con un grupo de investigadores del Grupo de Tecnologías Informáticas e Inteligencia Artificial (GTI-IA) de la UPV que han desarrollado unas herramientas para la formación automática de equipos de trabajo óptimos basándose en la Taxonomía de Roles”de Belbin (TRB). La metodología que estamos desarrollando parte de los datos de los perfiles de Belbin de los alumnos, obtenidos mediante encuestas realizadas por los alumnos al finalizar un determinado trabajo en equipo en una determinada asignatura, y utilizamos estas herramientas para establecer nuevos equipos de trabajo para abordar nuevos trabajos en equipo en la misma o en otras asignaturas. La metodología se evalúa mediante encuestas en las que los alumnos expresan su grado de satisfacción con el funcionamiento de los equipos al finalizar cada trabajo. Los resultados iniciales muestran que la línea de trabajo que estamos siguiendo parece bastante adecuada para conseguir los fines previstos al final del proyecto, y actualmente estamos trabajando en fases más avanzadas del proyecto, en el marco de un proyecto PIME de la UPV, con el fin de mejorar y terminar de implementar estas metodogías.Del Val Noguera, E.; Palomares Chust, A.; Alberola Oltra, JM.; Teruel Serrano, MD.; Fernández Méndez, MM.; Morant González, M.; Benlloch Aparisi, V. (2015). Desarrollo y evaluación de la competencia trabajo en equipo en el grado en Gestión Turística (Primera Fase). En In-Red 2015 - CONGRESO NACIONAL DE INNOVACIÓN EDUCATIVA Y DE DOCENCIA EN RED. Editorial Universitat Politècnica de València. https://doi.org/10.4995/INRED2015.2015.1570OC

Memoria del IV Coloquio Internacional sobre Diversidad Cultural y Estudios Regionales

Esta memoria del IV Coloquio Internacional sobre Diversidad Cultural y Estudios Regionales: Escenarios de la heterogeneidad, memorias y culturas, realizada por el Centro de Investigaciones sobre Diversidad Cultural y Estudios Regionales, CIDICER, en 2016, compila las ponencias presentadas, las cuales se organizan por ejes temáticos, en 7 apartados: Culturas, Identidades e Imaginarios, Literatura Cultura e Identidades, Estéticas de la Heterogeneidad, Pluriculturalidad y Grupos Minoritarios, Diversidad Cultural e Identidades, Literatura, Identidades y Género.UCR::Sedes Regionales::Sede de Occidente::Recinto San Ramón::Centro de Investigaciones sobre Diversidad Cultural y Estudios Regionales (CIDICER

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

Genome-wide association studies have generated an increasing number of common genetic variants associated with neurological and psychiatric disease risk. An improved understanding of the genetic control of gene expression in human brain is vital considering this is the likely modus operandum for many causal variants. However, human brain sampling complexities limit the explanatory power of brain-related expression quantitative trait loci (eQTL) and allele-specific expression (ASE) signals. We address this, using paired genomic and transcriptomic data from putamen and substantia nigra from 117 human brains, interrogating regulation at different RNA processing stages and uncovering novel transcripts. We identify disease-relevant regulatory loci, find that splicing eQTLs are enriched for regulatory information of neuron-specific genes, that ASEs provide cell-specific regulatory information with evidence for cellular specificity, and that incomplete annotation of the brain transcriptome limits interpretation of risk loci for neuropsychiatric disease. This resource of regulatory data is accessible through our web server, http://braineacv2.inf.um.es/

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation. Findings Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16–36% of the heritable risk of Parkinson's disease depending on prevalence. Integrating methylation and expression data within a Mendelian randomisation framework identified putatively associated genes at 70 risk signals underlying GWAS loci for follow-up functional studies. Tissue-specific expression enrichment analyses suggested Parkinson's disease loci were heavily brain-enriched, with specific neuronal cell types being implicated from single cell data. We found significant genetic correlations with brain volumes (false discovery rate-adjusted p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024), and educational attainment (p=0·038). Mendelian randomisation between cognitive performance and Parkinson's disease risk showed a robust association (p=8·00 × 10−7). Interpretation These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, to the best of our knowledge, by revealing many additional Parkinson's disease risk loci, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified. These associations derived from European ancestry datasets will need to be followed-up with more diverse data. Funding The National Institute on Aging at the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation (see appendix for full list of funding sources)

Concentración empresarial, internacionalización. Actuaciones del cooperativismo agrario en la Unión Europea

Fil: Juliá Igual, Juan Francisco.Fil: Fernández Méndez, Manuela