ROC curves to compare the ability of each miRNA to distinguish between different groups.

<p>(<b>A</b>) miR-138, (<b>B</b>) miR-376a and (<b>C</b>) miR-15b can distinguish between OB and CTR. (<b>D</b>) miR-138 (<b>E</b>) miR-376a (<b>F</b>) miR-15b can also distinguish between OB and OB-DM2. (<b>G</b>) miR-138 (<b>H</b>) miR-376a (<b>I</b>) miR-15b can distinguish between OB and DM2.</p

ROC curves to compare the ability of combinations of miRNAs to distinguish between DM2 and OB-DM2 groups.

<p>The combination of miR-503 and miR-138(<b>A</b>) and miR-503 and miR-376a (<b>B</b>) could distinguish DM2 from OB-DM2 patients. (<b>C</b>) The combination of miR-503 and miR-15b cannot distinguish between DM2 and OB-DM2 patients.</p

Comparison of the serum levels of miR-138(A), miR-376a (B), miR-15b (C) and miR-503 (D) in controls, DM2, OB and OB-DM2 groups.

<p>Graphs show median level with interquartile range. The Kruskal-Wallis test with Dunn´s post test was used to determine the significance of differences between groups. The serum levels were determined using RT-PCR following RNA extraction. Two technical replicates were performed on two cDNA replicates.</p

Comorbidities in the MHO subjects by W (Wildman), WM (Wildman modified) and CS (Consensus Societies) criteria according to the data shown in Table 1.

<p>BP: Elevated Blood Pressure, TG: Elevated Triglycerides, HDL-C: Decreased HDL-C; FG: Elevated Fasting Glucose, HOMA IR: Elevated Homeostasis Model Assessment Insulin Resistance, CRP: Elevated C Reactive Protein, WC: Large Waist Circumference.</p

Biochemical characteristics and lifestyle in individuals metabolically healthy and unhealthy with BMI ≥30 kg/m² by Wildman modified criteria, adjustment by age and sex.

<p>BMI: Body Mass Index; -X: Mean, CI: confidence interval HDL-C: High Density Lipoprotein Cholesterol; HOMA-IR: Homeostasis model assessment of insulin resistance; CRP:C-Reactive Protein, METs: Metabolic Equivalents.</p><p>Biochemical characteristics and lifestyle in individuals metabolically healthy and unhealthy with BMI ≥30 kg/m² by Wildman modified criteria, adjustment by age and sex.</p

Criteria: Wildman (W), Wildman modified (WM) and Consensus Societies (CS).

<p>HDL-C: High Density Lipoprotein Cholesterol, HOMA-IR: Homeostasis model assessment of insulin resistance, hsCRP: high sensitivity C Reactive Protein,</p><p>BMI: Body Mass Index.</p><p>Criteria: Wildman (W), Wildman modified (WM) and Consensus Societies (CS).</p

BMI, WC and WHR in detecting Framingham risk score (≥20%) and SCORE Project (≥5%).

<p>A.-The AUC was 0.739 (95%CI 0.719–0.759) for WC; 0.724 (95%CI 0.704–0.745) for WHR and 0.631 (95%CI 0.608–0.653) for BMI (p<0.001). B. - The AUC was 0.688 (95%CI 0.655–0.721) for WC; 0.746 (95%CI 0.719–0.773 for WHR, 0.523 (95%CI 0.486–0.561) for BMI (p<0.001).</p

Basic characteristics and anthropometric parameters in individuals with BMI ≥30 Kg/m² by Consensus Societies criteria, means adjustment by age and sex.

<p>BMI: Body Mass Index; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure, WC: Waist Circumference; HC: Hip Circumference; WHR: Waist to Hip Ratio;</p><p>*Mean ± (SD). -X: Mean, CI: confidence interval.</p>Δ<p>Logistic regression models independent variables: Framinghan and SCORE risk scores adjustment by age and sex. OR: Odd Ratio.</p><p>Basic characteristics and anthropometric parameters in individuals with BMI ≥30 Kg/m² by Consensus Societies criteria, means adjustment by age and sex.</p

Haplotypic frequencies and association analysis with OGTT values in Spanish population

<p>F: population frequency.</p

Baseline characteristics of study subjects.

<p>Baseline characteristics of study subjects.</p