Ophiuroidea of the Avilés Canyons System (INDEMARES + LIFE Project).

The Avilés Canyons System (ACS) is located in the Cantabrian Sea (Bay of Biscay) and is composed of three canyons. It was declared Site of Community Importance (SCI: C ESZZ12003) within the Natura 2000 Network (Ministry of Agriculture, Food and Environment, 2014) due to their diversity of species and vulnerable habitats (Sánchez et.al., 2014). During the years 2010 - 2012 several campaigns of the INDEMARES LIFE - ACS project were carried out. This study includes the zone that goes from the beginning of the continental slope to the maximum depth sampled in the bathyal zone (depth range between 266 and 2291 m). A total of 7413 specimens which correspond to 48 species, were collected from 50 stations. The most abundant species were Ophiocten affinis (Lütken, 1858) with 4092 specimens and Ophiothamnus affinis Ljungman, 1872 with 1842. The most frequent ones were Ophiactis abyssicola (M. Sars, 1861) and Ophiacantha bidentata (Bruzelius, 1805) present in 48% and 26% of stations respectively. Comparing our species with public databases (OBIS, GBIF) and the bibliography, five potential new records have been found for the Cantabrian Sea, part of the North-Atlantic Marine Subdivision (Lavín et. al., 2012).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Multifrequency filter search for high redshift sources and lensing systems in Herschel -ATLAS

We present a new catalog of high-redshift candidate Herschel sources. Our sample is obtained after applying a multifrequency filtering method (?matched multifilter?), which is designed to improve the signal-to-noise ratio of faint extragalactic point sources. The method is tested against already-detected sources from the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) and used to search for new high-redshift candidates. The multifilter technique also produces an estimation of the photometric redshift of the sources. When compared with a sample of sources with known spectroscopic redshift, the photometric redshift returned from the multifilter is unbiased in the redshift range 0.8?< ?z?< ?4.3. Using simulated data we reproduced the same unbiased result in roughly the same redshift range and determined the error (and bias above z???4) in the photometric redshifts. Based on the multifilter technique, and a selection based on color, flux, and agreement of fit between the observed photometry and assumed SED, we find 370 robust candidates to be relatively bright high-redshift sources. A second sample with 237 objects focuses on the faint end at high-redshift. These 237 sources were previously near the H-ATLAS detection limit but are now confirmed with our technique as high significance detections. Finally, we look for possible lensed Herschel sources by cross-correlating the first sample of 370 objects with two different catalogs of known low-redshift objects, the redMaPPer Galaxy Cluster Catalog and a catalog of galaxies with spectroscopic redshift from the Sloan Digital Sky Survey Data Release 14. Our search renders a number of candidates to be lensed systems from the SDSS cross-correlation but none from the redMaPPeR confirming the more likely galactic nature of the lenses

Anomalías sinópticas y su relación con el incremento de granizo en 2006

Ponencia presentada en: VIII Congreso de la Asociación Española de Climatología celebrado en Salamanca entre el 25 y el 28 de septiembre de 2012.[ES]Las tormentas de granizo son uno de los riesgos meteorológicos más importantes del SW de Europa. Concretamente el Valle Medio del Ebro (VME) es el área que registra la mayor frecuencia de eventos de granizo de España, con unas pérdidas económicas de alrededor de 100 M€ anuales. El Grupo de Física de la Atmósfera (GFA) de la Universidad de León realiza campañas de investigación en el VME desde 2001 de forma continuada, registrando un promedio de 60 días de tormenta cada verano, mediante un radar meteorológico.[EN]Hailstorms are one of the principal risks in the SW of Europe. Specifically, the Mid-Ebro Valley (VME), is the area that has the greatest frequency of registered hail events in Spain, with economic losses of approximately 100 M€ annually. The Group for Atmospheric Physics (GFA) at the University of León has done research campaigns in the VME continuously since 2001, registering 60 storm days per year via meteorological radar.Este estudio ha sido financiado por los proyectos REN 2000-1210 CLI, REN 2003-09617-C02-01, CGL 2006-13372-C02-01, CGL 2010-15930 del Plan Nacional del I+D+i

Evolution of legislation and crimes based on sexual identity or orientation in Spain: a retrospective observational study (2011-2021)

Respect for different sexual options and orientations prevents the occurrence of hate crimes against lesbian, gay, bisexual, trans and intersex (LGTBI) persons for this reason. Our aim was to review the legislation that protects the rights of LGTBI people and to quantify the victimization rates of hate crimes based on sexual identity and orientation. A retrospective observational study was conducted across all regions of Spain from 2011?2021. The laws on LGTBI rights in each region were identified. Hate crime victimization data on sexual identity and orientation were collected in annual rates per 100,000 inhabitants, annual percentage change and average change during the study period to assess the trend. The regulatory development of laws against discrimination against LGTBI individuals is heterogeneous across regions. Overall, in Spain there is an upward trend in the number of hate crime victimizations motivated by sexual identity or orientation. The effectiveness of data collection, thanks to better training and awareness of police forces regarding hate crimes and the processes of data cleansing and consolidation contributes to a greater visibility of hate crimes against LGTBI people

Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain

ContextSome reports suggest that acromegaly in elderly patients has a more benign clinical behavior and could have a better response to first-generation long-acting somatostatin receptor ligands (SRL). However, there is no specific therapeutic protocol for this special subgroup of patients. ObjectiveThis study aimed at identifying predictors of response to SRL in elderly patients. DesignMulticentric retrospective nationwide study of patients diagnosed with acromegaly at or over the age of 65 years. ResultsOne-hundred and eighteen patients (34 men, 84 women, mean age at diagnosis 71.7 +/- 5.4 years old) were included. Basal insulin-like growth factor type 1 (IGF-1) above the upper limit of normal (ULN) and growth hormone (GH) levels (mean +/- SD) were 2.7 +/- 1.4 and 11.0 +/- 11.9 ng/ml, respectively. The mean maximal tumor diameter was 12.3 +/- 6.4 mm, and up to 68.6% were macroadenoma. Seventy-two out of 118 patients (61.0%) underwent surgery as primary treatment. One-third of patients required first-line medical treatment due to a rejection of surgical treatment or non-suitability because of high surgical risk. After first-line surgery, 45/72 (63.9%) were in disease remission, and 16/34 (46.7%) of those treated with SRL had controlled disease. Patients with basal GH at diagnosis <= 6 ng/ml had lower IGF-1 levels and had smaller tumors, and more patients in this group reached control with SRL (72.7% vs. 33.3%; p < 0.04) [OR: 21.3, IC: 95% (2.4-91.1)], while male patients had a worse response [OR: 0.09, IC 95% (0.01-0.75)]. The predictive model curve obtained for SRL response showed an AUC of 0.82 CI (0.71-0.94). ConclusionsThe most frequent phenotype in newly diagnosed acromegaly in the elderly includes small adenomas and moderately high IGF-1 levels. GH at diagnosis <= 6 ng/ml and female gender, but not age per se, were associated with a greater chance of response to SRL

Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study

Molecular techniques are the gold standard method for the diagnosis of AML with mutated nucleophosmin gene (NPM1mut). However, their worldwide availability is limited and they provide limited insight into disease heterogeneity. Hence, surrogate markers of NPM1mut are used for fast diagnostic screening of the disease [1], including, among others, immunohistochemical detection of cytoplasmic NPM1 (NPM1c) [2], cup-like nuclear morphology [3], normal karyotype, and/or recurrent flow cytometry profiles -e.g., CD34 negativity, and/or a phenotype resembling acute promyelocytic leukemia (APL)- [4]. Nevertheless, some of these methods are also not widely available, they show limited sensitivity (e.g., low or absent NPM1c expression, particularly among monoblastic/monocytic AML-NPM1mut) [5], frequently lack standardized procedures [1], and they might also bring limited information about disease heterogeneity.This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI21/01115 and co-funded by the European Union and the grant of CIBERONC of the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain, and FONDOS FEDER (no. CB16/12/00400); MR was supported by the Ministry of Health of the Czech Republic, grant number NU20J-07-00028.Peer reviewe

Differences in the clinical and hormonal presentation of patients with familial and sporadic primary aldosteronism

Purpose: To compare the clinical and hormonal characteristics of patients with familial hyperaldosteronism (FH) and sporadic primary aldosteronism (PA). Methods: A systematic review of the literature was performed for the identification of FH patients. The SPAIN-ALDO registry cohort of patients with no suspicion of FH was chosen as the comparator group (sporadic group). Results: A total of 360 FH (246 FH type I, 73 type II, 29 type III, and 12 type IV) cases and 830 sporadic PA patients were included. Patients with FH-I were younger than sporadic cases, and women were more commonly affected (P = 0.003). In addition, the plasma aldosterone concentration (PAC) was lower, plasma renin activity (PRA) higher, and hypokalemia (P < 0.001) less frequent than in sporadic cases. Except for a younger age (P < 0.001) and higher diastolic blood pressure (P = 0.006), the clinical and hormonal profiles of FH-II and sporadic cases were similar. FH-III had a distinct phenotype, with higher PAC and higher frequency of hypokalemia (P < 0.001), and presented 45 years before sporadic cases. Nevertheless, the clinical and hormonal phenotypes of FH-IV and sporadic cases were similar, with the former being younger and having lower serum potassium levels. Conclusion: In addition to being younger and having a family history of PA, FH-I and III share other typical characteristics. In this regard, FH-I is characterized by a low prevalence of hypokalemia and FH-III by a severe aldosterone excess causing hypokalemia in more than 85% of patients. The clinical and hormonal phenotype of type II and IV is similar to the sporadic case

Evaluating Person-Centred Integrated Care to People with Complex Chronic Conditions: Early Implementation Results of the ProPCC Programme

Introduction: The evaluation of integrated care programmes for high-need high-cost older people is a challenge. We aim to share the early implementation results of the ProPCC programme in the North-Barcelona metropolitan area, in Catalonia, Spain. Methods: We analysed the intervention with retrospective data from May 2018 to December 2021 by describing the cohort complexity and by showing its 6-months pre-post impact on time spent at home and resources used: primary care visits, emergency department visits, hospital admissions and hospital stay. Findings: 264 cases were included (91% at home; 9% in nursing homes). 6-month pre vs. 6-months post results were (mean, p-value): primary care visits 8.2 vs. 11.5 (p < 0.05); emergency department visits 1.4 vs. 0.9 (p < 0.05); hospital admissions 0.7 vs. 0.5 (p < 0.05); hospital stay 12.8 vs. 7.9 days (p < 0.05). Time spent at home was 169.2 vs.174.2 days (p < 0.05). Conclusion: Early implementation of the ProPCC programme results in an increase in time spent at home (up to 3%) and significant reductions in emergency department attendance (–37.2%) and hospital stays (–38.3%). The increased use of primary care resources is compensated by the hospital resources savings, with a result in the average total cost of –46.3%

Autonomous cortisol secretion in patients with primary aldosteronism: prevalence and implications on cardiometabolic profile and on surgical outcomes

Purpose: The aim of this study was to evaluate the prevalence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic and surgical outcomes. Methods: This is a retrospective multicenter study of PA patients who underwent 1 mg dexamethasone-suppression test (DST) during diagnostic workup in 21 Spanish tertiary hospitals. ACS was defined as a cortisol post-DST >1.8 μg/dL (confirmed ACS if >5 μg/dL and possible ACS if 1.8–5 μg/dL) in the absence of spe cific clinical features of hypercortisolism. The cardiometabolic profile was compared with a control group with ACS without PA (ACS group) matched for age and DST levels. Results: The prevalence of ACS in the global cohort of patients with PA (n = 176) was 29% (ACS–PA; n = 51). Ten patients had confirmed ACS and 41 possible ACS. The cardiometabolic profile of ACS–PA and PA-only patients was simil ar, except for older age and larger tumor size of the adrenal lesion in the ACS–PA group. When comparing the ACS–PA group (n = 51) and the ACS group (n = 78), the prevalence of hypertension (OR 7.7 (2.64–22.32)) and cardiovascular events (OR 5.0 (2.29–11.07)) was higher in ACS–PA patients than in ACS patients. The coexistence of ACS in patien ts with PA did not affect the surgical outcomes, the proportion of biochemical cure and clinical cure being similar between ACS–PA and PA-only groups. Conclusion: Co-secretion of cortisol and aldosterone affects almost one-thi rd of patients with PA. Its occurrence is more frequent in patients with larger tumors and advanced age. However, the cardiometabolic and surgical outcomes of patients with ACS–PA and PA-only are similar