Solution to Faddeev equations with two-body experimental amplitudes as input and application to J^P=1/2^+, S=0 baryon resonances

We solve the Faddeev equations for the two meson-one baryon system $\pi\pi N$ and coupled channels using the experimental two-body $t$-matrices for the $\pi N$ interaction as input and unitary chiral dynamics to describe the interaction between the rest of coupled channels. In addition to the $N^*(1710)$ obtained before with the $\pi\pi N$ channel, we obtain, for $J^\pi=1/2^+$ and total isospin of the three-body system $I=1/2$, a resonance peak whose mass is around 2080 MeV and width of 54 MeV, while for $I=3/2$ we find a peak around 2126 MeV and 42 MeV of width. These two resonances can be identified with the $N^* (2100)$ and the $\Delta (1910)$, respectively. We obtain another peak in the isospin 1/2 configuration, around 1920 MeV which can be interpreted as a resonance in the $N a_0(980)$ and $N f_0(980)$ systems.Comment: published versio

Thermodynamics of a model for RNA folding

We analyze the thermodynamic properties of a simplified model for folded RNA molecules recently studied by G. Vernizzi, H. Orland, A. Zee (in {\it Phys. Rev. Lett.} {\bf 94} (2005) 168103). The model consists of a chain of one-flavor base molecules with a flexible backbone and all possible pairing interactions equally allowed. The spatial pseudoknot structure of the model can be efficiently studied by introducing a $N \times N$ hermitian random matrix model at each chain site, and associating Feynman diagrams of these models to spatial configurations of the molecules. We obtain an exact expression for the topological expansion of the partition function of the system. We calculate exact and asymptotic expressions for the free energy, specific heat, entanglement and chemical potential and study their behavior as a function of temperature. Our results are consistent with the interpretation of $1/N$ as being a measure of the concentration of $\rm{Mg}^{++}$ in solution.Comment: 11 pages, 4 figure

GeoCLEF 2006: the CLEF 2006 Ccross-language geographic information retrieval track overview

After being a pilot track in 2005, GeoCLEF advanced to be a regular track within CLEF 2006. The purpose of GeoCLEF is to test and evaluate cross-language geographic information retrieval (GIR): retrieval for topics with a geographic specification. For GeoCLEF 2006, twenty-five search topics were defined by the organizing groups for searching English, German, Portuguese and Spanish document collections. Topics were translated into English, German, Portuguese, Spanish and Japanese. Several topics in 2006 were significantly more geographically challenging than in 2005. Seventeen groups submitted 149 runs (up from eleven groups and 117 runs in GeoCLEF 2005). The groups used a variety of approaches, including geographic bounding boxes, named entity extraction and external knowledge bases (geographic thesauri and ontologies and gazetteers)

Challenges to evaluation of multilingual geographic information retrieval in GeoCLEF

This is the third year of the evaluation of geographic information retrieval (GeoCLEF) within the Cross-Language Evaluation Forum (CLEF). GeoCLEF 2006 presented topics and documents in four languages (English, German, Portuguese and Spanish). After two years of evaluation we are beginning to understand the challenges to both Geographic Information Retrieval from text and of evaluation of the results of geographic information retrieval. This poster enumerates some of these challenges to evaluation and comments on the limitations encountered in the first two evaluations

Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma

: Neuroblastoma is the most common extra-cranial solid tumour in children. Despite multi-modal therapy, over half of the high-risk patients will succumb. One contributing factor is the one-size-fits-all nature of multi-modal therapy. For example, during the first step (induction chemotherapy), the standard regimen (rapid COJEC) administers fixed doses of chemotherapeutic agents in eight two-week cycles. Perhaps because of differences in resistance, this standard regimen results in highly heterogeneous outcomes in different tumours. In this study, we formulated a mathematical model comprising ordinary differential equations. The equations describe the clonal evolution within a neuroblastoma tumour being treated with vincristine and cyclophosphamide, which are used in the rapid COJEC regimen, including genetically conferred and phenotypic drug resistance. The equations also describe the agents' pharmacokinetics. We devised an optimisation algorithm to find the best chemotherapy schedules for tumours with different pre-treatment clonal compositions. The optimised chemotherapy schedules exploit the cytotoxic difference between the two drugs and intra-tumoural clonal competition to shrink the tumours as much as possible during induction chemotherapy and before surgical removal. They indicate that induction chemotherapy can be improved by finding and using personalised schedules. More broadly, we propose that the overall multi-modal therapy can be enhanced by employing targeted therapies against the mutations and oncogenic pathways enriched and activated by the chemotherapeutic agents. To translate the proposed personalised multi-modal therapy into clinical use, patient-specific model calibration and treatment optimisation are necessary. This entails a decision support system informed by emerging medical technologies such as multi-region sequencing and liquid biopsies. The results and tools presented in this paper could be the foundation of this decision support system

Genetic variability and incidence of systemic diseases in wild vines (Vitis vinifera ssp. silvestris) along the Danube

In the riparian woods of Danube and March east of Vienna 87 wild specimens of Vitis vinifera ssp. silvestris were genetically analysed and compared. The silvestris population can be split into 6 distinct groups, but this clustering cannot be explained solely by the geographical distance. The unique genetic variability observed represents a strong case for preservation of wild grapevines.The incidence of bacterioses, viroses and nematodes transmitting nepoviruses to these vines were registered. None of the analysed specimens suffered from Agrobacterium vitis-induced crown gall. Only some vines were infected by viral pathogens such as GLRaV I and SLRV. Thus the wild vines do not constitute a risk for the surrounding commercial vineyards. On the other hand, diseases spread from cultivated grapevines may seriously harm the wild vine population. Four species of nematodes transmitting nepoviruses were registered. Samples of Xiphinema vuittenezi and Longidorus attenuatus from the Lobau (natural forests, north of the Danube in the area of Vienna) differ morphometrically from others found on arable soils or isolated from the research area.

Design of an electron microscope phase plate using a focused continuous-wave laser

We propose a Zernike phase contrast electron microscope that uses an intense laser focus to convert a phase image into a visible image. We present the relativistic quantum theory of the phase shift caused by the laser-electron-interaction, study resonant cavities for enhancing the laser intensity, and discuss applications in biology, soft materials science, and atomic and molecular physics.Comment: 5 pages, 3 figure

Predictors and outcomes of crossover to surgery from physical therapy for meniscal tear and osteoarthritis a randomized trial comparing physical therapy and surgery

BACKGROUND: Arthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomized to PT received APM before assessment of the primary outcome. We sought to identify factors associated with crossing over to APM and to compare pain relief between patients who had crossed over to APM and those who had been randomized to APM. METHODS: We used data from the MeTeOR (Meniscal Tear in Osteoarthritis Research) Trial of APM with PT versus PT alone in subjects ≥45 years old who had mild-to-moderate osteoarthritis and a degenerative meniscal tear. We assessed independent predictors of crossover to APM among those randomized to PT. We also compared pain relief at 6 months among those randomized to PT who crossed over to APM, those who did not cross over, and those originally randomized to APM. RESULTS: One hundred and sixty-four subjects were randomized to and received APM and 177 were randomized to PT, of whom 48 (27%) crossed over to receive APM in the first 140 days after randomization. In multivariate analyses, factors associated with a higher likelihood of crossing over to APM among those who had originally been randomized to PT included a baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Score of ≥40 (risk ratio [RR] = 1.99; 95% confidence interval [CI] = 1.00, 3.93) and symptom duration of <1 year (RR = 1.74; 95% CI = 0.98, 3.08). Eighty-one percent of subjects who crossed over to APM and 82% of those randomized to APM had an improvement of ≥10 points in their pain score at 6 months, as did 73% of those who were randomized to and received only PT. CONCLUSIONS: Subjects who crossed over to APM had presented with a shorter symptom duration and greater baseline pain than those who did not cross over from PT. Subjects who crossed over had rates of surgical success similar to those of the patients who had been randomized to surgery. Our findings also suggest that an initial course of rigorous PT prior to APM may not compromise surgical outcome. LEVEL OF EVIDENCE: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence

Generating functional for the gravitational field: implementation of an evolutionary quantum dynamics

We provide a generating functional for the gravitational field, associated to the relaxation of the primary constraints as extended to the quantum sector. This requirement of the theory, relies on the assumption that a suitable time variable exist, when taking the T-products of the dynamical variables. More precisely, we start from the gravitational field equations written in the Hamiltonian formalism and expressed via Misner-like variables; hence we construct the equation to which the T-products of the dynamical variables obey and transform this paradigm in terms of the generating functional, as taken on the theory phase-space. We show how the relaxation of the primary constraints (which correspond to break down the invariance of the quantum theory under the 4-diffeomorphisms) is summarized by a free functional taken on the Lagrangian multipliers, accounting for such constraints in the classical theory. The issue of our analysis is equivalent to a Gupta-Bleuler approach on the quantum implementation of all the gravitational constraints; in fact, in the limit of small $\hbar$, the quantum dynamics is described by a Schr\"odinger equation, as soon as the mean values of the momenta, associated to the lapse function and the shift vector, are not vanishing. Finally we show how, in the classical limit, the evolutionary quantum gravity reduces to General Relativity in the presence of an Eckart fluid, which corresponds to the classical counterpart of the physical clock, introduced in the quantum theory.Comment: 23 pages, no figures, to appear on International Journal of Modern Physics