Awareness and knowledge of cervical cancer and its screening methods among women attending primary healthcare centers in Zaria, North‑Western, Nigeria

Background: Cervical cancer is a leading cause of cancer death in many developing countries. Cervical cancer can be prevented by screening and treatment of premalignant lesions of the cervix. Primary healthcare centers are the health centers closest to the grassroots in Nigeria and thus may be appropriate for population‑based cervical cancer screening programs. This study sought to assess awareness of cervical cancer and its screening methods among women attending primary healthcare centers in Zaria, Nigeria.Methodology: It was a cross‑sectional study. Participants were women accessing healthcare in primary healthcare centers in Zaria. Eight primary healthcare centers in Zaria were purposively selected for the study. Data were obtained by focus group discussions (FGDs). The FGDs were tape‑recorded and transcribed verbatim. The transcripts obtained were analyzed into themes based on the objectives of the study.Results: The mean age of respondents was 26 years (standard deviation 4.9 years). Many participants were aware of symptoms of cervical cancer; however, they were not aware of the risk factors. Pap smear was the only screening method known to participants.Conclusion: Awareness of cervical cancer and cervical screening did not reflect adequate knowledge about cervical cancer and screening methods. There is a need for healthcare providers to offer adequate health education about the disease and screening methods.Keywords: Cervical cancer awareness; cervical cancer screening; primary healthcare attendee

Prevalence of diabetes in a semi-urban community in northern Nigeria.

Background: Diabetes mellitus is a growing public health problem both in developing and developed nations. The prevalence of diabetes globally is projected to rise from 2.8% in 2000 to 4.4% in 2030.This study was conducted to assess the prevalence of diabetes in Dakace village, near Zaria Method: This study was part of a larger study to assess the prevalence of cardiovascular disease risk factors among adults in Dakace village, near Zaria. Out of a total of 492 eligible respondents for the study, a subsample of 199 persons was recruited using a systematic sampling technique had their fasting blood glucose levels determined. Body mass indices of the participants were also determined. Results: A total of 199 subjects (94 males and 105 females) participated in this segment of the study. Three subjects had fasting blood glucose (FBG) of more than 7.0mmol/L; one participant a previously known diabetic on medication had a good glycaemic control. The overall prevalence of diabetes was 2.0%.Five participants (2.5%) had impaired fasting glucose (IFG). Among the diabetics, one was overweight (BMI= 27.43Kg/m2) and one was obese (BMI=31.55Kg/m2), while among those with impaired fasting glucose two were overweight. Fortythree subjects (21.6%) were overweight and 15 (7.5%) were obese. Conclusion: The prevalence of diabetes mellitus in this semi-urban community is keeping with what had been reported earlier from across the country.Nigerian Journal of Medicine Vol. 17 (4) 2008: pp. 414-41

Mortality and cause of death in Abuth, Zaria: 1999-2005

Background: Accurate mortality statistics are needed for policy formulation,implementation and monitoring of health intervention that are aimed at improving the health status of the people. Mortality level is one of the indicators of the quality of life and status of health of a population. However, accurate collection, collation, analysis and interpretation of such data is poorly organised in developing nations, including Nigeria leading to a gap in health policy formulation, implementation and monitoring. Therefore, policies and strategies for disease prevention are based on empirical evidence rather than on data primarily collected to formulate disease specific interventions.Though, hospital data have inherent deficiency in its use to design prevention. However, when accurately generated and adequately managed would provide both qualitative and quantitative information on morbidity and mortality if not for the entire society at least for a segment of the population utilizing it. We implemented a system of death certification to determine causes and pattern of mortality in Ahmadu Bello University Teaching Hospital, Zaria Methods: From May 1999 to November 2005, all case folders of deceased patients were retrieved from the central library of health information management department of the hospital; case folders of deceased patients are required to have in them a completed IFMCCD(International Form of Medical Certification of Cause of Death). All case folders of deceased patients after relevant information were extracted by the staff of health management information department, were passed on to the staff of department of Community Medicine directly involved in this study. The completed cause of death certificates received in the department of Community Medicine (between May 1999 and November 2005), were examined. Coding rules were employed to select the appropriate code for those certificates that were incorrectly completed. The underlying cause of death as identified from the correctly completed IFMCCDS is coded according to ICD-10.Results: For the period under study, there were 4019 deaths: 2212 males and 1807 females. Total of 2914 (72.5%) deaths were certified, using the IFMCCD of which 1641 of them were males and 1273 females and formed the basis of this analysis. Coverage rates ranges from 56.2% in 2001 to 85% in 1999. The proportion of garbage codes ranges from 0% to 2.4% while the three leading causes of death are HIV infection, road traffic accident (RTA), and cardiovascular diseases among the ten. The time-trend of the leading causes of death show RTA maintaining steady upward climb while malaria, septicemia, PEM, sepsis in the neonatal period shows unsteady fluctuation. Conclusion: This study assessed the pattern of mortality and causes of death in ABU Teaching Hospital, Zaria; it also provided information on leading causes of death

A short list of Equalities induces large sign-rank

We exhibit a natural function Fn on n variables that can be computed by just a linear-size decision list of "Equalities," but whose sign-rank is 2Ω (n1/4). This yields the following two new unconditional complexity class separations. 1. Boolean circuit complexity. The function Fn can be computed by linear-size depth-two threshold formulas when the weights of the threshold gates are unrestricted (THR ∘ THR), but any THR ∘ MAJ circuit (the weights of the bottom threshold gates are polynomially bounded in n) computing Fn requires size 2Ω (n1/4). This provides the first separation between the Boolean circuit complexity classes THR ∘ MAJ and THR ∘ THR. While Amano and Maruoka [Proceedings of the 30th International Symposium on Mathematical Foundations of Computer Science, 2005, pp. 107-118] and Hansen and Podolskii [Proceedings of the 25th Annual IEEE Conference on Computational Complexity, 2010, pp. 270-279] emphasized that superpolynomial separations between the two classes remained a basic open problem, our separation is in fact exponential. In contrast, Goldmann, Håstad, and Razborov [Comput. Complexity, 2 (1992), pp. 277-300] showed more than twenty-five years ago that functions efficiently computable by MAJ ∘ THR circuits can also be efficiently computed by MAJ ∘ MAJ circuits. In view of this, it was not even clear if THR ∘ THR was significantly more powerful than THR ∘ MAJ until our work, and there was no candidate function identified for the potential separation. 2. Communication complexity. The function Fn (under the natural partition of the inputs) lies in the communication complexity class PMA. Since Fn has large sign-rank, this implies PMA ⊈ UPP, strongly resolving a recent open problem posed by Göös, Pitassi, and Watson [Comput. Complexity, 27 (2018), pp. 245-304]. In order to prove our main result, we view Fn as an XOR function and develop a technique to lower bound the sign-rank of such functions. This requires novel approximation-theoretic arguments against polynomials of unrestricted degree. Further, our work highlights for the first time the class "decision lists of exact thresholds" as a common frontier for making progress on longstanding open problems in threshold circuits and communication complexity

EXAFS study of intermetallics of the type RGe<SUB>2</SUB> (R=La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er and Y) Part I: determination of Ge-Ge distances

A study of the EXAFS associated with the K x-ray absorption discontinuity of germanium in pure germanium and in the rare-earth germanides RGe2 (where R=La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er and Y) has been carried out. The Ge-Ge distances have been obtained in these compounds. Considering the phase to the RGe2 system, the bond lengths in these compounds have been determined. The values obtained by us for the RGe2 compounds (R=La, Ce, Pr, Nd, Sm, Gd, Dy and Y) agree with those obtained earlier by crystallographic methods. The bond lengths for the compounds TbGe2, HoGe2 and ErGe2 are also being reported

Lifting to parity decision trees via Stifling

We show that the deterministic decision tree complexity of a (partial) function or relation f lifts to the deterministic parity decision tree (PDT) size complexity of the composed function/relation f ◦ g as long as the gadget g satisfies a property that we call stifling. We observe that several simple gadgets of constant size, like Indexing on 3 input bits, Inner Product on 4 input bits, Majority on 3 input bits and random functions, satisfy this property. It can be shown that existing randomized communication lifting theorems ([Göös, Pitassi, Watson. SICOMP'20], [Chattopadhyay et al. SICOMP'21]) imply PDT-size lifting. However there are two shortcomings of this approach: first they lift randomized decision tree complexity of f, which could be exponentially smaller than its deterministic counterpart when either f is a partial function or even a total search problem. Second, the size of the gadgets in such lifting theorems are as large as logarithmic in the size of the input to f. Reducing the gadget size to a constant is an important open problem at the frontier of current research. Our result shows that even a random constant-size gadget does enable lifting to PDT size. Further, it also yields the first systematic way of turning lower bounds on the width of tree-like resolution proofs of the unsatisfiability of constant-width CNF formulas to lower bounds on the size of tree-like proofs in the resolution with parity system, i.e., Res(☉), of the unsatisfiability of closely related constant-width CNF formulas

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly

The final version of this article is available at the link below.Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an accessory subunit, E3BP (E3-binding protein). Its icosahedral E2/E3BP 60-meric ‘core’ provides the central structural and mechanistic framework ensuring favourable E1 and E3 positioning and enzyme co-operativity. Current core models indicate either a 48E2+12E3BP or a 40E2+20E3BP subunit composition. In the present study, we demonstrate clear differences in subunit content and organization between the recombinant hPDC core (rhPDC; 40E2+20E3BP), generated under defined conditions where E3BP is produced in excess, and its native bovine (48E2+12E3BP) counterpart. The results of the present study provide a rational basis for resolving apparent differences between previous models, both obtained using rhE2/E3BP core assemblies where no account was taken of relative E2 and E3BP expression levels. Mathematical modelling predicts that an ‘average’ 48E2+12E3BP core arrangement allows maximum flexibility in assembly, while providing the appropriate balance of bound E1 and E3 enzymes for optimal catalytic efficiency and regulatory fine-tuning. We also show that the rhE2/E3BP and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC comprises a heterogeneous population of assemblies incorporating a network of E3 (and possibly E1) cross-bridges above the core surface.This work was partly supported by EPSRC (under grants GR/R99393/01 and EP/C015452/1)

Influence of monsoon regime and microclimate on soil respiration in the tropical forests

The consequence of precipitation and how environmental factors influence soil respiration remain poorly understood in the tropical forest ecosystems under a monsoon climate in Malaysia. This study was conducted in a recovering tropical lowland Dipterocarpus forest in Peninsular Malaysia, and its monthly variations were examined in association with changing precipitation. Soil respiration was measured using a continuous open flow chamber system connected to a multi gas-handling unit and an infrared gas analyser. The aim of this study was to determine the effects of the monsoon period and microclimate of the tropical region on soil respiration. The average monthly soil respiration rates were 152.79 to 528.67, 120.97 to 500.73, 106.77 to 472.89, 122.89 to 453.89 and 120.33 to 434.89 mg m⁻² h⁻¹ in the respective months from September to January. The emission rate varied across the days and months, with the highest value recorded between September and October, and then gradually decreasing from November to January. Soil temperature explained more than 90% of the soil respiration rate whereas precipitation had a major effect during the monsoon regime. Soil organic carbon (SOC), total organic carbon (TOC), soil organic carbon stock (SOCstock), forest biomass, carbon to nitrogen ratio (C/N) and soil pH were found to vary in considerable amounts, provide nutrients and the environment favourable for microorganism activities, leading to emission of soil CO₂. The low values of soil respiration rate between November and January were due not only on the amount of soil moisture and water potential but also on the intensity and frequency of precipitation. Therefore, these results indicate that the monsoon regime can significantly alter the emission of soil CO₂ and influence the microclimatic conditions and other environmental factors

Rainfall trend detection in Northern Nigeria over the period of 1970-2012

This study examined the trends in variability and spatial distribution of annual rainfall over northern Nigeria during the period 1970-2012 with a view to understand the pattern of rainfall trend (significance and magnitude), by applying various statistical tools on the data obtained from 11 weather stations. The non-parametric Mann– Kendall test was used to determine the statistical significance of trends while the magnitude of trends was derived from the Sen slope estimator of the linear trends using Kendall robust line fitting. Map of rainfall trends was generated by applying a geo-statistical interpolation technique to visualize the detected tendencies. The findings revealed that a significant positive increase of 2.16mm in rainfall was recorded in the entire northern Nigeria within the period of 1970 to 2012. It further indicated that majority of the stations revealed an upward trend, with Bauchi, Borno, Kebbi and Sokoto stations showing significant positive trends of 8.13mm, 4.30mm, 4.76mm and 4.42mm respectively. It is concluded that there is high variability in rainfall in the northern Nigeria which signifies a clear evidence of climate change in the region