Deflection and Friction Performance of Waste-Wooden Block Pavements

The use of waste wood for road light pavements is essential for environmental and economic sustainability.The paper investigates the mechanical performance of pavements built with waste wood elements discarded from Sardinia manufacture (Italy). Without structural value, mainly Sardinian wood is used for combustion and heating due to the characteristics of dimensional irregularity, non-homogeneity, and the presence of defects. Even small urban and forest furniture comes from foreign markets. Landscape reasons, emissions reduction, and environmental integration with the local context could encourage its use if reliable techniques are available.The study first analyzed the structural response of a portion of pavementmade with waste wood bricks (pine and Eucalyptus). Subsequently, a Finite Element simulation of the pavement has been validated with the tests' results. The experimental pavement was created with Interlocked Block Pavement (IBP) technique, using brick elements 13 x 6 x 10 cm. The behavior of the pavement was analyzed in situ with dynamic deflection tests using the Falling Weight Deflectometer test (FWD). Further tests performed in the laboratory investigated the friction of the wood pavement surface. The simulation results show that the wooden pavement elements do not differ substantially from the classic concrete IBP and HMA cracked pavement. The mean deflections are greater than 19%, while the vertical stress on the foundation layer is equivalent. As with the classic concrete IBP, the results largely depend on the bearing capacity of the substrate and the degree of interlocking.Friction tests show good values with mean values of 53 divided by 64 BPN. The most significant values were observed in the elements eucalyptus. The direction of the wood fibers also influences the results: about 3 points in the case of pine and over 7 points in the case of Eucalyptus. The study shows how the use of wood for the pavement with elements is sustainable and practicable due to the minor and low-traffic roads while also guaranteeing permeability and low-cost maintenance

A swift approach for identifying vulnerable linear transport infrastructures in areas prone to floods and erosion

Linear transport infrastructures are essential for the socio-economic development of industrialized countries. However, adverse meteorological and hydrogeological events can result in significant economic losses.Globally, floods have the most substantial socio-economic impact. Climate Change, due to the extent of transport infrastructures over flood-prone territories, is a very important factor in worsening flood risk.The main objective of this study is to identify the sections of the hydrographic network that are susceptible to flood and erosion hazards where road infrastructures are located. The Metropolitan City of Cagliari (Sardinia, Italy) is selected as test site, due to the presence of several coastal watersheds and of a high population density.A swift methodological approach, based on already available datasets from public repositories and GIS analyses, is presented. This approach includes: i) geomorphological characterization of the hydrographic network; ii) census of stream tracts where bridges were damaged in past flood events; iii) identification of potentially critical tracts (PCT), based on similar geomorphological conditions; iv) multi-temporal satellite imagery analysis of PCT for the identification of flood-prone areas and, therefore, vulnerable road crossings.The adopted methodology has proved to be effective for the identification of vulnerable road crossings over wide portion of territories, identifying critical sites that need further investigation

Real-time evaluation of the on-board comfort of standing passenger in bus transit services

Bus on-board comfort may be intended as a multidimensional concept declined according to several attributes (e.g., vibrations, the load factor, the driving style, etc.) and represents a key factor of service quality. Thus, its measurement is crucial for public transport companies as it can support for the monitoring, evaluation and implementation of specific actions to improve their services. The objective of this paper is to build a numerical scale for real-time measurement of bus on-board comfort. This is pursued integrating subjective measurements of the driving style provided by the passengers with objective ones of longitudinal and transversal accelerations data collected by Intelligent Transportation System tools. The results are very useful because they represent a contribution to establish a comfort scale in a real operational environment, as a tool to regulate the driver's behavior: each driver is in the position of real-time monitoring the quality of a bus ride regarding on-board comfort level

Circulating adrenomedullin levels and Doppler-derived dP/dt in idopathic cardiomyopathy

Chronic heart failure (CHF) is characterized both by ventricular and vascular remodeling. Osteopontin (OP) is an extracellular matrix protein,that might have a role as a marker of ventricular remodelling, its expression being increased in myocardial tissue of CHF patients from biopsies. Adrenomedullin (AM), a potent vasodilator peptide secreted by endothelial cells, and endothelin (ET), a substance with long-acting vasocostrictor action, might express the paracrine vasomotor response to CHF progression

Ig Glycosylation in Ulcerative Colitis: It’s Time for New Biomarkers

Background: Ulcerative colitis (UC) is a chronic relapsing disease, which needs a continue monitoring, especially during biological therapies. An increasing number of patients is treated with anti-Tumor Necrosis factor (TNF) drugs, and current research is focalized to identify biomarkers able to monitor the disease and to predict therapeutic outcome. Methods: We enrolled consecutive UC patients treated with anti-TNF, naïve to biologic drugs. Therapeutic outcome was evaluated after 54 weeks of treatment in terms of clinical remission (Partial Mayo Score -PMS- <2) and mucosal healing (Mayo Endoscopic Score <2). On serum samples collected at baseline and after 54 weeks of treatment, a Lectin-based ELISA assay was performed, and specific glycosylation patterns were evaluated by biotin-labelled lectins. We have also collected 21 healthy controls (NHS) samples, age and sex-matched. Results: Out of 44 UC patients enrolled, 22 achieved clinical remission and mucosal healing after 54 weeks. At baseline, when Protein A was used as coating, UC patients non-responders showed a reduced reactivity to Jacalin (JAC) in comparison with NHS (p = 0.04). After one year of treatment, a decrease in JAC binding was seen only in responders, in comparison with baseline (p = 0.04). When JAC binding was tested selecting IgG by means of Fab anti-IgG Fab, UC patients displayed an increased reactivity after anti-TNF therapy (p < 0,0001 vs controls). At baseline, PMS inversely correlates with JAC binding when Fab anti-IgG Fab was used in solid phase (r2 = 0,2211; p = 0,0033). Patients with higher PMS at baseline (PMS ≥5) presented lower binding capacity for JAC in comparison with NHS and with lower PMS patients (p = 0,0135 and p = 0,0089, respectively). Conclusion: Ig glycosylation was correlated with clinical and endoscopic activity in patients with UC. JAC protein A-selected Ig showed a possible role in predicting therapeutic effectiveness. If these data would be confirmed, Ig glycosylation could be used as biomarker in UC

Osteopontin plasma levels and accelerated atherosclerosis in patients with CAD undergoing PCI: a prospective clinical study.

OBJECTIVES: Growing evidence supports the role played by inflammation in atherosclerosis. Identifying sensitive biomarkers is useful in predicting accelerated atherosclerosis. We investigated prospectively the relationship between plasma levels of inflammatory biomarkers [osteopontin, C-reactive protein (CRP), interleukin-6 (IL-6)] and instent restenosis, and rapid coronary plaque progression in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). METHODS: We studied 77 patients with CAD: 45 affected by unstable angina/non-ST elevation myocardial infarction [acute coronary syndrome (ACS)], and 32 by chronic coronary syndrome (CCS). Plasma osteopontin, IL-6, and CRP levels were measured before intervention in all patients; measurements were carried out on the basis of the following time course at 1,15, 30, 90, and 180 days follow-up in a subgroup of 39 consenting patients. Clinical and biohumoral data were correlated with baseline and 6-month PCI follow-up angiography. RESULTS: Osteopontin, IL-6, and CRP were higher in patients with ACS than in those with CCS (analysis of variance: P<0.001, 0.05, and 0.05, respectively). Baseline osteopontin levels proved to be associated with rapid coronary plaque progression (P=0.005) and instent restenosis (P=0.05). The highest osteopontin levels were found in patients with CAD with both rapid plaque progression and instent restenosis (P=0.003). PCI increased inflammatory markers acutely, and osteopontin remained elevated in patients with ACS. Patients with ACS showed a higher percentage (74%) of rapid plaque progression than those with CCS (26%) (P<0.05). CONCLUSION: The study prospectively shows the link between inflammatory status and accelerated atherosclerosis in patients with CAD undergoing PCI. The baseline and persistent rise of osteopontin is an expression of its contribution to the accelerated plaque progression, and therefore osteopontin may be a useful prognostic biomarker

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks