129 research outputs found
Preterm birth after loop electrosurgical excision procedure (LEEP). how cone features and microbiota could influence the pregnancy outcome
OBJECTIVE:
In the last years, the mean age of women who underwent cervical treatment for high-grade cervical intraepithelial neoplasia (CIN 2-3) is similar to the age of women having their first pregnancy. The aim of this study was to evaluate the risk of preterm birth in subsequent pregnancies after loop electrosurgical excision procedure (LEEP).
PATIENTS AND METHODS:
From January 2013 to January 2016 the study identified a total of 1435 women, nulliparous, who underwent LEEP for CIN 2-3, and who wished to have their first pregnancy. Before surgery, the lengths of the cervix were calculated by transvaginal sonography. After the treatment, the dimension of the removed tissue was evaluated. During the pregnancy, all women carried out periodic transvaginal sonography and vaginal-cervical swabs.
RESULTS:
The average age of patients was 31.96±5.24 years; the interval between the surgical procedure and pregnancy was 12.04±4.67 months; the gestational age at births was 37.53±2.91 weeks. The first vaginal and cervical swab performed during pregnancy was negative in 81.8% of patients. The most prevalent infections were related to C. Albicans, G. Vaginalis, and Group B Streptococcus (GBS). The rate of preterm delivery was significantly higher in women with a minor cervical length.
CONCLUSIONS:
The length and the volume of cervical tissue excised have been shown to be directly related to the risk for preterm birth. Furthermore, vaginal infections and their persistence during pregnancy in women with a history of LEEP may be associated with an increased risk for preterm birth, compared with women with no history of LEEP
Occultation analysis of BATSE data: Operational aspects
The Burst and Transient Source Experiment (BATSE) large area detectors are being used to monitor hard x-ray/gamma ray sources on a daily basis for evidence of transient behavior. Flux measurements are performed using a simple earth occultation technique. Daily searches are also being performed to detect occultation steps of sources which are not being routinely monitored. Topics concerning the operational aspects of the occultation measurements are presented. Preliminary spectral results are also presented for several of the brighter sources
BATSE Observations of Gamma-Ray Burst Spectra. IV. Time-Resolved High-Energy Spectroscopy
We report on the temporal behavior of the high-energy power law continuum
component of gamma-ray burst spectra with data obtained by the Burst and
Transient Source Experiment. We have selected 126 high fluence and high flux
bursts from the beginning of the mission up until the present. Much of the data
were obtained with the Large Area Detectors, which have nearly all-sky
coverage, excellent sensitivity over two decades of energy and moderate energy
resolution, ideal for continuum spectra studies of a large sample of bursts at
high time resolution. At least 8 spectra from each burst were fitted with a
spectral form that consisted of a low-energy power law, a spectral break at
middle energies and a high-energy continuum. In most bursts (122), the
high-energy continuum was consistent with a power law. The evolution of the
fitted high-energy power-law index over the selected spectra for each burst is
inconsistent with a constant for 34% of the total sample. The sample
distribution of the average value for the index from each burst is fairly
narrow, centered on -2.12. A linear trend in time is ruled out for only 20% of
the bursts, with hard-to-soft evolution dominating the sample (100 events). The
distribution for the total change in the power-law index over the duration of a
burst peaks at the value -0.37, and is characterized by a median absolute
deviation of 0.39, arguing that a single physical process is involved. We
present analyses of the correlation of the power-law index with time, burst
intensity and low-energy time evolution. In general, we confirm the general
hard-to-soft spectral evolution observed in the low-energy component of the
continuum, while presenting evidence that this evolution is different in nature
from that of the rest of the continuum.Comment: 30 pages, with 2 tables and 9 figures To appear in The Astrophysical
Journal, April 1, 199
Reduction of the Superfluid Density in the Vortex-Liquid Phase of Bi2Sr2CaCu2Oy
In-plane complex surface impedance of a Bi2Sr2CaCu2Oy single crystal was
measured in the mixed state at 40.8 GHz.The surface reactance, which is
proportional to the real part of the effective penetration depth, increased
rapidly just above the first-order vortex-lattice melting transition field and
the second magnetization peak field.This increase is ascribed to the decrease
in the superfluid density rather than the loss of pinning.This result indicates
that the vortex melting transition changes the electronic structure as well as
the vortex structure.Comment: 4 pages, 4 figures, accepted for publication in Phys. Rev. Let
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome.
Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioral and physiological symptoms. Mutations in the methyl CpG binding protein 2 gene (MECP2) cause more than 95% of classic cases, and currently there is no cure for this devastating disorder. Recently we have demonstrated that specific behavioral and brain molecular alterations can be rescued in MeCP2-308 male mice, a RTT mouse model, by pharmacological stimulation of the brain serotonin receptor 7 (5-HT7R). This member of the serotonin receptor family-crucially involved in the regulation of brain structural plasticity and cognitive processes-can be stimulated by systemic repeated treatment with LP-211, a brain-penetrant selective 5-HT7R agonist. The present study extends previous findings by demonstrating that the LP-211 treatment (0.25 mg/kg, once per day for 7 days) rescues RTT-related phenotypic alterations, motor coordination (Dowel test), spatial reference memory (Barnes maze test) and synaptic plasticity (hippocampal long-term-potentiation) in MeCP2-308 heterozygous female mice, the genetic and hormonal milieu that resembles that of RTT patients. LP-211 also restores the activation of the ribosomal protein (rp) S6, the downstream target of mTOR and S6 kinase, in the hippocampus of RTT female mice. Notably, the beneficial effects on neurobehavioral and molecular parameters of a seven-day long treatment with LP-211 were evident up to 2 months after the last injection, thus suggesting long-lasting effects on RTT-related impairments. Taken together with our previous study, these results provide compelling preclinical evidence of the potential therapeutic value for RTT of a pharmacological approach targeting the brain 5-HT7R
The Fourth BATSE Gamma-Ray Burst Catalog (Revised)
The Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray
Observatory (CGRO) has triggered on 1637 cosmic gamma-ray bursts between 1991
April 19 and 1996 August 29. These events constitute the Fourth BATSE burst
catalog. The current version (4Br) has been revised from the version first
circulated on CD-ROM in September 1997 (4B) to include improved locations for a
subset of bursts that have been reprocssed using additional data. A significant
difference from previous BATSE catalogs is the inclusion of bursts from periods
when the trigger energy range differed from the nominal 50-300 keV. We present
tables of the burst occurrence times, locations, peak fluxes, fluences, and
durations. In general, results from previous BATSE catalogs are confirmed here
with greater statistical significance.Comment: 45 pages, 12 Postscript figures, accepted for publication in Ap. J.
Supp
Using the Active Collimator and Shield Assembly of an EXIST-Type Mission as a Gamma-Ray Burst Spectrometer
The Energetic X-ray Imaging Survey Telescope (EXIST) is a mission design
concept that uses coded masks seen by Cadmium Zinc Telluride (CZT) detectors to
register hard X-rays in the energy region from 10 keV to 600 keV. A partially
active or fully active anti-coincidence shield/collimator with a total area of
between 15 and 35 square meters will be used to define the field of view of the
CZT detectors and to suppress the background of cosmic-ray-induced events. In
this paper, we describe the use of a sodium activated cesium iodide
shield/collimator to detect gamma-ray bursts (GRBs) and to measure their energy
spectra in the energy range from 100 keV up to 10 MeV. We use the code GEANT4
to simulate the interactions of photons and cosmic rays with the spacecraft and
instrument and the code DETECT2000 to simulate the optical properties of the
scintillation detectors. The shield collimator achieves a nu-F-nu sensitivity
of 3 x 10^(-9) erg cm^(-2) s^(-1) and 2 x 10^(-8) erg cm^(-2) s^(-1) at 100 keV
and 600 keV, respectively. The sensitivity is well matched to that of the coded
mask telescope. The broad energy coverage of an EXIST-type mission with active
shields will constrain the peak of the spectral energy distribution (SED) for a
large number of GRBs. The measurement of the SED peak may be key for
determining photometric GRB redshifts and for using GRBs as cosmological
probes.Comment: 20 pages, 10 Figures, Accepted May 19, 2006 A&
BATSE observations of 3C273
The quasar 3C273 has been detected by all instruments on CGRO. The emission from this source is monitored continuously by BATSE using Earth occultation. We present results of a preliminary analysis of BATSE data, including light curves of the 3C273 flux covering approximately 150 days in the interval April-August 1991 and approximately 350 days in the interval July 1992-April 1993. The source intensity in the energy range 50-300 keV is typically approx. 0.002 ph cm(exp -2)s(exp -1). We find weak evidence for variations of as much as a factor of 3 in the intensity. We derive spectral parameters of 3C273 during the intervals TJD 8422-8435 (15-28 June 1991) and TJD 8532-8546 (3-17 October 1991) for comparison with other CGRO instruments
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