Fetal and maternal outcomes among pregnant women with placental abruption associated with disseminated intravascular coagulation attending a rural tertiary care centre

Background: Placental abruption is the separation of the placenta from the uterine wall before the delivery of the fetus, and its frequency varies between 0.4 and 1%. The objective of this study was to determine risk factors and maternal and fetal complications in cases of abruptio placentae.Methods: A record-based study was conducted in the Obstetrics and Gynaecology department at a rural tertiary care centre between January 2015 and December 2019. All 72 pregnant women admitted with suspicion of placental abruption at 28 weeks of gestation and beyond were included in the study. All data were retrieved from the maternity register, patient files. The maternal outcome was assessed by mode of delivery, need for blood transfusion, parity, and any complications. Neonatal outcome was assessed by neonatal intensive care unit admission, still and live births. Data collected was entered and analysed by using coGuide software.Results: A total of 72 subjects were included in the final analysis. Most 58 (81%) of them were 21-30 years old. Forty-three patients (59.72%) were diagnosed to be preeclamptic. Forty-three (59.72%) of them had a vaginal delivery. Out of 72, 66 (91.67%) patients did not have any maternal complications. Most 41 (56.94%) births were stillbirths, and only 7 (9.72%) newborns required intensive care unit (ICU) admission.Conclusions: Placental abruption is one of the major threats to the well-being of pregnant women, with an alarmingly high rate of 41 (56.94%) stillbirths

Legacy Digital Transformation: TCO and ROI Analysis

Legacy Digital Transformation is modernizing or migrating systems from non-digital or older digital technology to newer digital technologies. Digitalization is essential for information reading, processing, transforming, and storing. Social media, Cloud, and analytics are the major technologies in today\u27s digital world. Digitalization (business process) and Digital Transformation (the effect) are the core elements of newer global policies and processes. Recent COVID pandemic situation, Organizations are willing to digitalize their environment without losing business. Digital technologies help to improve their capabilities to transform processes that intern promote new business models. Applications cannot remain static and should modernize to meet the evolving business and technology needs. Business needs time to market, Agility, and reduce technical debt. Technology needs consist of APIs, better Security, Portability, Scalability, Cloud support, Deployment, Automation, and Integration. This paper elaborates different transformation/modernization approaches for Legacy systems written in very long or End of Life (EOL) systems to newer digital technologies to serve the business needs. EOL impacts application production, supportability, compliance, and security. Organizations spend money and resources on Digital Transformation for considering Investment versus Return on Investment, Agility of the System, and improved business processes. Migration and Modernization are critical for any Legacy Digital Transformation. Management takes decisions to proceed with Digital Transformation for considering Total Cost Ownership (TCO) and Return on Investment (ROI) of the program. The paper also includes a TCO-ROI calculator for Transformation from Legacy / Monolithic to new architectures like Microservices

Using a disk operator to convert raster images of engineering drawings to vector images

Computer Scienc

Contact force sensing in ablation of ventricular arrhythmias using a 56-hole open-irrigation catheter: a propensity-matched analysis.

PURPOSE: The effect of adding contact force (CF) sensing to 56-hole tip irrigation in ventricular arrhythmia (VA) ablation has not been previously studied. We aimed to compare outcomes with and without CF sensing in VA ablation using a 56-hole radiofrequency (RF) catheter. METHODS: A total of 164 patients who underwent first-time VA ablation using Thermocool SmartTouch Surround Flow (TC-STSF) catheter (Biosense-Webster, Diamond Bar, CA, USA) were propensity-matched in a 1:1 fashion to 164 patients who had first-time ablation using Thermocool Surround Flow (TC-SF) catheter. Patients were matched for age, gender, cardiac aetiology, ejection fraction and approach. Acute success, complications and long-term follow-up were compared. RESULTS: There was no difference between procedures utilising either TC-SF or TC-STSF in acute success (TC-SF: 134/164 (82%), TC-STSF: 141/164 (86%), p = 0.3), complications (TC-SF: 11/164 (6.7%), TC-STSF: 11/164 (6.7%), p = 1.0) or VA-free survival (TC-SF: mean arrhythmia-free survival time = 5.9 years, 95% CI = 5.4-6.4, TC-STSF: mean = 3.2 years, 95% CI = 3-3.5, log-rank p = 0.74). Fluoroscopy time was longer in normal hearts with TC-SF (19 min, IQR: 14-30) than TC-STSF (14 min, IQR: 8-25; p = 0.04). CONCLUSION: Both TC-SF and TC-STSF catheters are safe and effective in treating VAs. The use of CF sensing catheters did not improve safety or acute and long-term outcomes, but reduced fluoroscopy time in normal heart VA

Nanometer-scale optical imaging of collagen fibers using gold nanoparticles

We describe 3D single particle tracking of gold nanoparticles (AuNPs) moving along collagen fibers in aqueous environment with two-photon excitation conditions. The photoacoustic effect at the collagen fiber caused by the irradiation with ultrashort, near-infrared laser pulses propels the particles adsorbed to the surface of the collagen fibers. We report the tracking of individual AuNPs in three dimensions with high spatial and temporal resolution, of few nanometers and milliseconds, respectively. Due to the emission signal caused by the interaction between the AuNPs and the weak chromophores in the collagen fiber, the trajectories of individual AuNPs reveal the fiber topography with nanometric resolution. The intensity along the trajectory shows that we are sensitive to the distribution of the weak chromophores on the fiber