Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives

A series of novel 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives (6a-h) and (7a-e) were synthesized by nucleophilic substitution reaction of 1-(1,4-benzodioxane-2-carbonyl)piperazine (3) with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, 1H NMR and LC-MS spectral studies. All compounds were evaluated for in vitro antibacterial, antifungal and antioxidant activities. Compound, 4-(2-trifluoromethyl)-benzenesulfonyl-1-(1,4-benzodioxane -2-carbonyl)piperazine (6b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound, 4-(3-methoxy)-benzoyl-1-(1,4-benzodioxane-2-carbonyl)piperazine (7a) showed moderate antioxidant activity compared to standard drug by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay method

Certain results on Kenmotsu pseudo-metric manifolds

In this paper, a systematic study of Kenmotsu pseudo-metric manifolds are introduced. After studying the properties of this manifolds, we provide necessary and sufficient condition for Kenmotsu pseudo-metric manifold to have constant $\varphi$-sectional curvature, and prove the structure theorem for $\xi$-conformally flat and $\varphi$-conformally flat Kenmotsu pseudo-metric manifolds. Next, we consider Ricci solitons on this manifolds. In particular, we prove that an $\eta$-Einstein Kenmotsu pseudo-metric manifold of dimension higher than 3 admitting a Ricci soliton is Einstein, and a Kenmotsu pseudo-metric 3-manifold admitting a Ricci soliton is of constant curvature $-\varepsilon$.Comment: 17 page

2-Methyl-3-(5-methyl-2-thien­yl)-5-phenyl­perhydro­pyrrolo[3,4-d]isoxazole-4,6-dione

In the mol­ecule of the title compound, C17H16N2O3S, the phenyl ring is oriented with respect to the thio­phene and succinimide rings at dihedral angles of 88.08 (3) and 57.81 (3)°, respectively; the dihedral angle between the thio­phene and succinimide rings is 35.69 (3)°. The isoxazole ring adopts an envelope conformation with the N atom at the flap position. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into infinite chains along the b axis. Weak C—H⋯π inter­actions may further stabilize the structure

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazole derivatives and their in vivo anticonvulsant activity

A series of 2,5-disubstituted-1,3,4-thiadiazole derivatives were synthesized by the reaction of 3-(2-cyanopropan-2-yl)-N-(5-(piperazine-1-yl)-1, 3,4-thiadiazol-2-yl)benzamide with various sulfonyl chlorides and evaluated for their anticonvulsant activity in MES test. Rotorod method was employed to determine the neurotoxicity. The purity of the compounds is confirmed on the basis of their elemental analysis. The structures of all the new compounds are established on the basis of 1H NMR and mass spectral data. Out of fifteen compounds, three were found to be potent anticolvunstants. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg)

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazole derivatives and their in vivo anticonvulsant activity

A series of 2,5-disubstituted-1,3,4-thiadiazole derivatives were synthesized by the reaction of 3-(2-cyanopropan-2-yl)-N-(5-(piperazine-1-yl)-1, 3,4-thiadiazol-2-yl)benzamide with various sulfonyl chlorides and evaluated for their anticonvulsant activity in MES test. Rotorod method was employed to determine the neurotoxicity. The purity of the compounds is confirmed on the basis of their elemental analysis. The structures of all the new compounds are established on the basis of 1H NMR and mass spectral data. Out of fifteen compounds, three were found to be potent anticolvunstants. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg)

Nutritional Studies and Antioxidant Profile of Pickled Oyster Mushrooms of North East India

Mushroom is a very popular food that is consumed around the globe yet it finds very limited acceptance in India, that too mainly among the elite. Non-availability of mushrooms around the year and its highly perishable nature makes it an expensive commodity for the common people to afford. Hence pickling may be viewed as a method to increase the shelf life of oyster mushrooms from 4-7 days under refrigerated condition to at least up to 12 months at room temperature. Hence a recipe for pickling of mushrooms using Indian spices was formulated so as to suit the Indian palate. The proximate analysis, calorific value, mineral and fatty acid profile along with antioxidant profile of the mushroom pickle was elucidated. Sensory parameters and shelf life and stability determining data like pH, titratable acidity and microbiological profile of the pickle was also performed. Finally it was observed that the mushroom pickle formulation has a shelf life of at least 12 months at room temperature with an overall acceptability (OAA) score above ‘very good’ mark

Macro micronutrients and Antioxidant Potentials of Plants and Fungal based Food from Tawang Area Arunachal Pradesh India

Certain variety of plants such as vegetables, spices and seaweed are abundantly being grown in high altitude cold desert region of Tawang in Arunachal Pradesh, India. Therefore, five different vegetables, spices and seaweed were taken from that particular cold region viz., finger millet, nori seaweed, pepper corn, bean and mushroom have been selected based on the higher consumption of people of Northeast (NE) India for the proximate analysis, mineral, antioxidant and vitamin contents. So far, there is no nutritional composition studies have been carried out with available vegetables, spices and seaweeds growing in NE. For this reason, this study was undertaken to determine the macro and micro nutrients and antioxidant potential of these plant foods. Different analyzed varieties were significantly different for proximate composition and mineral content, and each variety showed significant differences. Common bean showed higher percentage of protein with 35.09% and fat percentage of the finger millet is higher (9.2%) as compared to other varieties from other regions (1-1.5%). Higher crude fibre was assessed in mushroom with 47.77% followed with pepper corn (38.42%), bean with 30.987%, and finger millet (5.14%).Calcium was higher in finger millet with 225 mg per 100g whereas iron content was higher in mushroom with 652 mg followed with beans (543 mg), pepper corn (408 mg per 100g). Higher amount of polyphenols observed in finger millet with 8.716 µg (GAE)/mg and highest total flavonoids in pepper corn with 48.196 µg (RU)/ml. Likewise, highest FRAP in finger millet noticed with 72.0 µg of FeSO4 equivalent /mg and reducing power (ascorbic acid equivalent /mg) in mushroom (244.0) and pepper corn (242.0). All samples had higher metal chelating activity between 86.657- 83.383 IC50 µg. Similarly, higher amount of vit B6 was noted in pepper corn with 197.0 mg while lowest in seaweed with 1.76 mg/100gm. &nbsp

Lettuce: a promising leafy vegetable with functional properties

Lactuca sativa (lettuce) belongs to Asteraceae family important leafy vegetable known for its medicinal properties. The lettuce is a food that should not lack in our meals, we should keep in mind that its low fat and carbohydrate contents and its high contents of water, it provides caloric power of only 13 Kcal /100gm are very appropriate for weight loss diets. It is rich in minerals, especially potassium that is very necessary to maintain appropriate levels of liquids in the body, together with calcium and phosphorus makes it especially for the correct well being of the bones. It contains selenium, an antioxidant that has a medicinal property in prevention of certain type of cancers, colon, prostrate and lungs. It contains many necessary amino acids for the formation of the proteins, alanine, and necessary for the construction of muscular and nervous tissues, glycine for the correct operation of immunological system. The most of therapeutic properties of this plant is due to sesquiterpene lactones- lactucin, lactucopicrin the most bioactive compound of Lactuca sativa. This review mainly focuses on the pharmacological action of the Lettuce and active constituents for the wide spectrum biological properties, such as anti-oxidant, anti-inflammatory, anti-microbial, analgesic, neuroprotective and sedative properties etc. Since Lettuce has medicinal therapeutic potential its usage in dietary supplementation can be exploited. Lettuce has also acquired a folk reputation. More clinical studies are needed to further asses the efficiency and safety in therapeutic applicatio