65 research outputs found
Pregnancy Outcome in Women Having Oligohydramnios in Gandaki Medical College Teaching Hospital, Pokhara, Nepal
Background: Amniotic fluid index is one of the most commonly used methods of amniotic fluid volume assessment and is a predictor of adverse maternal and perinatal outcome.
Objectives: To compare the maternal and perinatal outcome in women with singleton term pregnancies having amniotic fluid index (AFI) ≤5 cm to those having AFI ≥5 to 20 cm.
Methods: This is a prospective, case-control study which was conducted at Gandaki Medical College Teaching Hospital over a period of one year from July 2017 to July 2018. It included 60 pregnant women at term pregnancy with amniotic fluid index ≤5 cm. The control group included 60 pregnant women at term pregnancy with amniotic fluid index ≥5 cm. The two groups were compared. Statistical analysis was done using the Chi-square test to calculate the P- value.
Results: There was a significantly higher incidence of overall cesarean rates due to fetal distress, low birth weight babies and adverse neonatal outcome like 5 minute Apgar score ≤7, neonatal intensive care unit (NICU) admission rates, and meconium aspiration syndrome in the group with oligohydramnios as compared to the group with normal liquor volume.
Conclusion: Oligohydramnios adversely affects the perinatal outcome. However a favorable outcome can be expected by good antenatal and intrapartum surveillance and neonatal care
Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma - a systematic review
Screening of HLA antibodies in maternal sera from Hyderabad
Antibodies against human leucocyte antigens (HLA) in sera from uni and multiparous women are the potential source of HLA reagent. The present study was undertaken to screen 169 sera from pregnant women for the presence of HLA antibodies employing 26 panel cells (Peripheral blood lymphocytes) having known HLA phenotypes. 20.7% (35/169) sera were found to be positive for HLA class-1 antibodies. Present study generated one monospecific, (r=0.6 for A32) the duospecific sera (r=0.5 for A2 B35, r=0.47 A1 DR6 and r=0.7 A28 B51), and rest multispecific sera (r=below 0.4). These positive sera will be utilized as HLA reagents in future studies for tissue typing
Association of family history of type 2 diabetes mellitus with markers of endothelial dysfunction in South Indian population
93-98<span style="font-size:
9.0pt;mso-bidi-font-size:11.0pt" lang="EN-US">Studies indicate that risk for type 2 diabetes
mellitus (T2D) or cardiovascular disease is detectable in childhood, though
these disorders may not emerge until adulthood. This study was aimed to assess
the markers of endothelial dysfunction in patients with the family history of
T2D from South Indian population. A total of 450 subjects were included in the
study comprising Group I (n = 200) of T2D, Group II (n = 200) of age- and
sex-matched healthy controls, Group III (n = 25) of children of T2D patients
and Group IV (n = 25) of children of healthy controls. Results showed that
intimal medial thickening (IMT) was significantly higher in T2D patients,
compared with control subjects with no family history of diabetes. The fasting
plasma glucose, glycated hemoglobin, serum total cholesterol, triglyceride, LDL-cholesterol,
apolipoprotein B (ApoB) and high-sensitive C-reactive protein (hsCRP) levels
were significantly increased, whereas
HDL-cholesterol and serum nitrite levels were significantly decreased in T2D
patients. However, children of T2D patients who were not diabetic did not show
significant increase in the IMT, as compared to those of healthy controls. In
conclusion, the present study demonstrated that IMT was significantly higher in
the T2D patients and increased with age and family history. The increased
levels of lipids, hsCRP, IMT and decreased nitrite levels might contribute to
the risk of endothelial dysfunction in patients with T2D. However, further
studies are warranted with other biomarkers of endothelial dysfunction in T2D
patients with increased sample size.
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Cardioprotective effect of magnesium chloride in experimental acute myocardial infarction
131-137Cardioprotective
role of intravenous administration of magnesium chloride was evaluated in rabbits
by biochemical and histopathological parameters. Myocardial damage was induced
by injecting (iv) isoprenaline 1, 2.5, 5 and 7.5 mg/kg body weight of animal.
There was a dose dependent increase in the activity of cardiac enzyme creatinine
kinase CK (C Max). Maximal elevation of CK (C Max) was observed with 2.5 mg
isoprenaline. The mean T-max (mean of the time duration in hr at which maximum
creatinine kinase activity of individual rabbit was observed in a group) shifted
early, significantly with 2.5, 5 and 7.5 mg isoprenaline compared to control group.
Histopathologically, myocardial damage was quite significant in 2.5 mg isoprenaline
subgroup of animals. A mortality of 29% was observed in animals injected with 5
and 7.5
mg isoprenaline,
whereas all animals subjected with 1 and 2.5 mg isoprenaline were alive for 72 hr.
Considering the data on serial determination of cardiac enzyme CIS and histopathological
changes, 2.5 mg isoprenaline was chosen as standard dose to study efficacy of
cardioprotection by gold standard verapamil and magnesium chloride. Verapamil
(5μM) injected prior to 2.5 mg isoprenaline administration revealed significant
reduction of CK (C Max) activity (P < 0.05) compared to animals infused
with isoprenaline alone. T-max value did not show any alteration in both the groups.
Histopathological findings showed no areas of necrosis and cellular infiltrates
in animals primed with 2.5 mg isoprenaline following verapamil. Highly significant
reduction in CK (C-max) activity was observed in animals administered with 40
mg magnesium chloride prior to isoprenaline compared to animals treated with
isoprenaline alone (P < 0.001). In addition to this, significant delay
in T-max of CK activity was observed in group treated with 40 mg magnesium
chloride and isoprenaline compared to group treated with only isoprenaline (P
< 0.01). The study clearly highlighted and confirmed the valuable role of
magnesium chloride as cardioprotective agent
Stability of total and free prostate specific antigen in serum samples at different storage conditions
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