P4-NetFPGA-based network slicing solution for 5G MEC architectures

Network Slicing is one of the fundamental capabilities of the new Fifth-generation (5G)networks. It is defined as several logical networks that are created to fulfil specific Quality of Service (QoS)and Quality of Experience (QoE)requirements and are available over the same physical infrastructure. This paper proposes a novel extension to P4-NetFPGA framework to achieve network slicing between different 5G users in the edge-to-core network segment. This solution provides hardware-isolation of the performance in terms of bandwidth, latency and packet loss of 5G network traffic. The work proposed has been validated in a real 5G infrastructure

NetFPGA-based firewall solution for 5G multi-tenant architectures

Future fifth-generation (5G) mobile networks entails architectural and network changes, mainly motivated by the idea of sharing resources between different network operators, which implies a reduction of the costs, thanks to the deployment of virtualised scenarios in shared infrastructures, and an improvement of the network usability. These architectural changes should guarantee that security and 5G Key Performance Indicators (KPIs) are achieved in 5G multi-tenant scenarios. The deployment of advanced architectures and network scenarios for the emerging 5G networks involves a renovation of the elements that compose them. Nowadays, there is no hardware solution which ensures the protection in 5G edge to core multi-tenant scenarios, therefore this paper proposes a fully functional 5G firewall based on a Field Programmable Gate Array (FPGA) that allows effective detention of cyber-attacks in 5G multi-tenant scenarios with user mobility support. The prototyped 5G firewall has been empirically evaluated to validate new capabilities in a 5G edge-to-core scenario. Moreover, an extensive performance and scalability test of the prototyped system has been carried out in a realistic testbed

DIMENSIONAMIENTO DE CRISTALES DE AZÚCAR A PARTIR DE PROCESAMIENTO DE IMÁGENES (SIZING OF SUGAR CRYSTALS BY IMAGE PROCESSING)

Resumen En este trabajo se determinaron las áreas superficiales y los volúmenes de cristales de azúcar capturados en un microscopio. El área superficial se determina a partir del análisis de imágenes, para ello se determinan los bordes de los cristales que se muestren completos y ortorrómbicos en la pantalla. Con la determinación de las áreas de los cristales se crea una relación dentro del programa para generar el valor del volumen. El procesamiento aquí mostrado puede ser empleado en línea o procesando un video pregrabado. En este caso, para grabar se utilizó un celular que grababa a través de la mirilla de un microscopio mientras los cristales pasabas por una celda de cristal. El análisis cuenta con un error del 0.8016% en comparación al método mie, utilizado en un MasterSizer. Palabras clave: Procesamiento imagen, cristales, dimensionamiento. Abstract In this work, the surface areas and volumes of sugar crystals captured under a microscope were determined. The surface area is determined from image analysis by determining the edges of the crystals that appear complete and orthorhombic on the screen. With the determination of the crystal areas a relation is created within the program to generate the volume value. The processing shown here can be employed online or by processing a pre-recorded video. In this case, a cell phone was used to record through a microscope scope while the crystals were passing through a crystal cell. The analysis has an error of 0.8016% compared to the mie method used in MasterSizer. Keywords: Image processing, crystals, sizing.>/em

Synchronous Rotation in the (136199) Eris–Dysnomia System

We combine photometry of Eris from a 6 month campaign on the Palomar 60 inch telescope in 2015, a 1 month Hubble Space Telescope WFC3 campaign in 2018, and Dark Energy Survey data spanning 2013–2018 to determine a light curve of definitive period 15.771 ± 0.008 days (1σ formal uncertainties), with nearly sinusoidal shape and peak-to-peak flux variation of 3%. This is consistent at part-per-thousand precision with the P = 15.785 90 ± 0.00005 day sidereal period of Dysnomia's orbit around Eris, strengthening the recent detection of synchronous rotation of Eris by Szakáts et al. with independent data. Photometry from Gaia are consistent with the same light curve. We detect a slope of 0.05 ± 0.01 mag per degree of Eris's brightness with respect to illumination phase averaged across g, V, and r bands, intermediate between Pluto's and Charon's values. Variations of 0.3 mag are detected in Dysnomia's brightness, plausibly consistent with a double-peaked light curve at the synchronous period. The synchronous rotation of Eris is consistent with simple tidal models initiated with a giant-impact origin of the binary, but is difficult to reconcile with gravitational capture of Dysnomia by Eris. The high albedo contrast between Eris and Dysnomia remains unexplained in the giant-impact scenario

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Título: Excelencias del glorioso Apostol Santiago

ColofónMarca de editor en páxina 96Sinatura.: []¡1, *¡8, A-L¡8, M¡7 ; []¡2, A-Z¡8, 2A-2D¡8, 2E¡6, Ú-2Ú¡8, Ú¡2Texto a dúas columnas.Anteportada.Frontispicio calcográfico arquitectónico: "P¡o de Villafranca sculptor Regis sculpsit Matriti 1658", en cada parte."Parte segunda de las excelencias y primacias del glorioso Apostol Santiago... : diuidida en dos libros / compuestos por el... Padre Geronimo Pardo... de los Clerigos Menores..., 1657", con port. y pag. propia