Changes in the phenolic complex of red aboriginal grape varieties in the system “grapes – base wine sparkling wine”

Due to the increased consumer interest in domestic wine products, winemaking enterprises are paying special attention to the use of aboriginal grape varieties now, in order to give products with distinctive characteristics, enabling to take the rightful place in wine market. However, there is no sufficient information about changes in the phenolic complex of grapes in the process of producing sparkling wines from red aboriginal varieties. The phenolic complex of grapes, base wines and sparkling wines produced from them was assessed, followed by the correlation established between the content of total phenolic, including coloring, substances in base wines and sparkling wines with their initial content and macerating (extracting) ability of these grape components, with corresponding correlation coefficients, which can be used for targeted regulation of accumulating these components

Special characteristics of technological indicators of white aboriginal grape varieties

Sparkling wines are high in demand, and they firmly occupy their strong position in wine market. In recent years, there was a reorientation of consumers from the low-price segment of sparkling wines to the mid-price and premium ones, motivating the manufacturer to be searching for new solutions for the unique high-quality wine production. One of the ways of its producing is the use of aboriginal grape varieties. At the same time, there is insufficient information about the distinctive technological characteristics of aboriginal grape varieties, which makes it difficult to release a product of high-quality. As a research result, significant indicators were established (the mass concentrations of titratable acids, proteins, polysaccharides, the content of phenolic substances in the must without contact with the pulp, the content of phenolic substances in the must after extraction of the pulp for 4 hours, the technological stock of phenolic substances) to differentiate grapes in accordance with the origin, and characterize their technological potential. A comparative analysis of aboriginal grape varieties with classical cultivars traditionally used in sparkling wine production was carried out. Deviations in the criterion technological indicators of aboriginal grape varieties were established to be taken into account when selecting grape processing technology for high-quality sparkling wine production

ОСОБЕННОСТИ ЛУЧЕВОЙ ТОКСИЧНОСТИ ПРИ ПРОВЕДЕНИИ ЛУЧЕВОЙ ТЕРАПИИ С ТРАСТУЗУМАБОМ

The aim of the study was to determine and analyze the most significant risk factors for developing cardiac, pulmonary and skin toxicities among patients who received concurrent radiation therapy and chemotherapy with trastuzumab.Material and methods. The study included 66 patients with histologically verified invasive intermediate or low-grade breast carcinoma, who received radiation therapy and chemotherapy with trastuzumab from 2018 to 2019. The average age of the patients was 53.1 ± 4.2 years. Locally advanced stage iii a and iii b breast cancer was the most common (52 %) followed by stage ii a and ii b cancer (36 %). The lvef of all patients was ≥50 %. All patients received neoadjuvant chemotherapy with anthracyclines and/or taxanes. Radiation-induced side effects were assessed using the rtog/eortc scoring criteria. Dose-volume histogram (dvh) of radiotherapy planning was matched to the quantec criteria.Results. Radiation-induced pulmonitis was observed in 2 patients within 2 to 6 months after the completion of radiation therapy. A 10 % reduction in lvef was observed in 3 patients, while a 20 % decrease in ef was not found. Long qt syndrome was observed in 3 patients, and it was accompanied by clinical manifestations in 2 patients. When evaluating the echo-cg protocols after treatment, normal lv diastolic function was recorded in 39 patients, moderate diastolic dysfunction (lv dd) in 27, and 1 patient had severe lv dd. When assessing the dose received by the lv myocardium, the excess of the average dose to the myocardium was present both on the left and on the right. Only in 16 % of cases, left myocardial irradiation met criterion v 25. Clinically, arrhythmias, unstable angina pectoris, and other manifestations of coronary artery disease were mostly observed among patients with left-sided breast cancer. Significant factors for the development of cardiotoxicity were left-sided breast cancer, previous chemotherapy with anthracyclines and/or taxanes, as well as myocardial doses. The occurrence of radiation pulmonitis did not show an obvious relationship with any factor, while the body mass index (bmi) of >30 was a significant factor for the occurrence of radiation-induced skin damage.Conclusion. The combination of radiation therapy and trastuzumab was associated with an acceptable risk of cardiotoxicity. Monitoring of the cardiovascular system parameters during treatment and detection of early signs of cardiotoxicity were shown to be of great importance.Целью исследования являлись определение и анализ наиболее значимых факторов, влияющих на развитие явлений кардио-, пульмо- и кожной токсичности среди пациенток, получавших лучевую терапию одновременно с введением трастузумаба.Материал и методы. В исследование вошли 66 пациенток с гистологически верифицированной инвазивной карциномой молочной железы умеренной и низкой степени дифференцировки, которые с 2018 по 2019 г. в ГБУЗ ЧОКЦО и ЯМ получали лучевую терапию с одновременной таргетной терапией трастузумабом. Средний возраст составил 53,1 ± 4,2 года. У 52 % пациенток диагностирован местнораспространенный рак молочной железы (iiia и iiiB стадии), у 36 % пациенток – iia и iiB стадий. Фракция выброса левого желудочка (ФВ ЛЖ) у всех пациенток составила ≥50 %. Все пациентки получили неоадъювантную химиотерапию с включением антрациклинов и/или таксанов. Явления токсичности оценивались по шкале Rtog/eoRtc для ранней лучевой токсичности. Гистограмма объема дозы (dVH) планов лучевой терапии соотносилась с критериями QuaNtec.Результаты. Лучевой пульмонит был зарегистрирован у 2 пациенток в сроки от 2 до 6 мес после окончания лучевой терапии. У 3 пациенток отмечалось снижение ФВ ЛЖ на 10 % от исходного значения, снижение ФВ на 20 % от исходного уровня не зарегистрировано. Удлинение интервала Qt зафиксировано у 3 пациенток, что у 2 больных сопровождалось клиническими проявлениями. При оценке протоколов ЭХО-КГ после проведения лечения у 39 пациенток отсутствовали нарушения функции ЛЖ, умеренная диастолическая дисфункция (ДД ЛЖ) зарегистрирована у 27, выраженная ДД ЛЖ – у 1 пациентки. Превышение средней дозы на миокард присутствовало и слева, и справа. Клинически значимые аритмии, нестабильная стенокардия и другие проявления ишемической болезни сердца в большинстве случаев наблюдались у пациенток с левосторонней локализацией рака молочной железы. Значимыми факторами кардиотоксичности стали левосторонняя локализация процесса, предшествующая полихимиотерапии антрациклинами и/или таксанами, а также доза, полученная миокардом. Возникновение лучевого пульмонита оказалось не связанным с какими-либо факторами, для возникновения лучевого дерматита значимым фактором оказался индекс массы тела пациенток >30 кг/м2.Заключение. Сочетание лучевой терапии и трастузумаба ассоциировано с приемлемым риском кардиотоксичности, при этом большое значение имеют мониторинг показателей сердечнососудистой системы в процессе лечения и диагностика ранних признаков кардиотоксичности

НЕЙТРОННАЯ ЛУЧЕВАЯ ТЕРАПИЯ В ЛЕЧЕНИИ РЕЦИДИВОВ ВЫСОКОЗЛОКАЧЕСТВЕННЫХ ГЛИОМ ГОЛОВНОГО МОЗГА

 The main objective of this study was to determine the place and role of neutron radiation therapy in the treatment of patients with recurrent high-grade glioma. Material and Methods. Treatment outcomes were analyzed in 40 patients who were treated at Oncology Center (Chelyabinsk) and Center for Neutron Therapy (Snezhinsk) from 2005 to 2015. The median age of patients was 45 years. The male to female ratio was 1:1. Recurrent glioblastoma was diagnosed in 19 patients, and anaplastic astrocytoma was revealed in 21 patients. Twenty patients underwent neutron therapy alone,and 20 patients underwent combined neutronphoton radiation therapy. The median overall survival time for all patients with recurrent high-grade glioma was 50 months. The 1-year, 2-year and 3-year survival rates were 94.1 %, 77.8 % and 66.7 % respectively.Results. The median survival time after treatment for relapse was 27 months. The main prognostic factors affecting the treatment outcomes were the age of the patients, histological verification and time to relapse. The method-specific overall survival rate was significantly higher in patients who underwent combined neutron-photon radiation therapy than in patients who underwent neutron therapy alone (48 months versus 20 months, p=0.05).  Целью исследования явилось определение места и роли нейтронной лучевой терапии в лечениипациентов с рецидивами высокозлокачественных глиом головного мозга. Материал и методы. Были проанализированы результаты лечения 40 больных, получивших лечение с 2005 по 2015 г. на базе ГБУЗ «Челябинский областной клинический центр онкологии и ядерной медицины» и Центра нейтронной  терапии (г. Снежинск). Средний возраст пациентов – 45 лет.  Соотношение мужчин и женщин – 1:1. У 19 пациентов был рецидив глиобластомы, у 21 – анапластической астроцитомы. В 20 случаях проведена нейтронная терапия в самостоятельном варианте, 20 больным проведен курс сочетанной нейтронно-фотонной лучевой терапии. Результаты. Медиана общей выживаемости для всех пациентов с рецидивами высокозлокачественных глиом головного мозга после проведенного лечения составила 50 мес, показатели 1-летней общей выживаемости – 94,1 %; 2-летней – 77,8 %; 3-летней – 66,7 %. Медиана выживаемости после лечения рецидива – 27 мес. Основными  прогностическими факторами, влияющими на результаты лечения, стали возраст пациентов, гистологическое  заключение, а также время до возникновения рецидива. Метод-специфическая выживаемость была достоверно выше у пациентов с проведением сочетанной нейтронно-фотонной терапии: 48 мес против 20 мес при проведении нейтронной терапии в самостоятельном варианте (р=0,05).

РЕЗУЛЬТАТЫ СОЧЕТАННОЙ ЛУЧЕВОЙ ТЕРАПИИ РАКА ПИЩЕВОДА С ПРИМЕНЕНИЕМ БРАХИТЕРАПИИ ВЫСОКОЙ МОЩНОСТИ

Between 2008 and 2015, 82 patients with inoperable esophageal cancer were treated with radiation therapy. The patients were divided into 3 groups. Group I consisted of 30 patients, who received external beam radiation therapy (EBRT) in combination with brachytherapy. Group II and group III patients (30 and 22 patients, respectively) received EBRT alone. Patients of group II received EBRT at a total dose of 60–70 Gy and patients of group III received EBRT at a total dose of 40–50 Gy. Treatment outcomes were better in patients treated with combination of EBRT and brachytherapy than in patients treated with EBRT alone. There was no significant difference between groups 2 and 3 with regard to their survival rates. Two-year overall survival rates in group I, II and III were 36 %, 12 % and 12 % and the median overall survival time was 15.7; 9.7 and 6.6 months, respectively.Проведено сравнительное исследование с включением 82 пациентов, страдающих раком пищевода, получивших самостоятельный курс лучевой терапии. В первую группу вошли 30 пациентов, получивших сочетанную лучевую терапию с брахитерапией, во 2-ю группу – 30 пациентов, получивших дистанционную лучевую терапию (ДЛТ) до суммарной дозы 60–70 Гр, у 22 пациентов 3-й группы суммарная доза ДЛТ была ограничена 40–50 Гр. Результаты лечения оказались лучше в группе сочетанной лучевой терапии, в то время как значение суммарной дозы ДЛТ не повлияло на показатели выживаемости. Двухлетняя общая выживаемость в сравниваемых группах составила 36, 12 и 12 %, медиана общей выживаемости – 15,7; 9,7 и 6,6 мес соответственно.

Integration of physical and spiritual recreation of youth in the socio-educational animation

Purpose - to reveal the possibilities of physical and spiritual recreation by combining them in the process of socio-educational animation. It examines the conceptual apparatus, which is the basis of development of methodology for the study of the recreational potential of the animation. Investigated the social and educational value of the integration of physical and spiritual recreation during the implementation of the animation activity among young people. The paper summarizes the current trends of social and pedagogical aspects of physical recreation. We consider the interpretation of the essence of the animation, which is to enhance the personality of its involvement in activities account recreational and educational opportunities animation. Defended the idea that the physical recovery - the basis of social optimism and social creativity. Settles integrated approach to social and educational animations to enhance the physical and social activity of the young man, the prevention of social passivity. Provides advanced methods and forms of recreation during the implementation of the animation business. It is proposed to use intensively games, theatrical performances, tourist travel, sports event

Tetrapalladium-Containing Polyoxotungstate [Pd4IIPd^{II}_4(α-P2W15O56)2P_2W_{15}O_{56})_2]16–{}^{16–}: A Comparative Study

The novel tetrapalladium(II)-containing polyoxometalate [PdII4(α-P2W15O56)2]16– has been prepared in aqueous medium and characterized as its hydrated sodium salt Na16[Pd4(α-P2W15O56)2]·71H2O by single-crystal XRD, elemental analysis, IR, Raman, multinuclear NMR, and UV–vis spectroscopy. The complex exists in anti and syn conformations, which form in a 2:1 ratio, and possesses unique structural characteristics in comparison with known {M4(P2W15)2} species. 31P and 183W NMR spectroscopy are consistent with the long-term stability of the both isomers in aqueous solutions

Integration of physical and spiritual recreation of youth in the socio-educational animation

<p>Purpose - to reveal the possibilities of physical and spiritual recreation by combining them in the process of socio-educational animation. It examines the conceptual apparatus, which is the basis of development of methodology for the study of the recreational potential of the animation. Investigated the social and educational value of the integration of physical and spiritual recreation during the implementation of the animation activity among young people. The paper summarizes the current trends of social and pedagogical aspects of physical recreation. We consider the interpretation of the essence of the animation, which is to enhance the personality of its involvement in activities account recreational and educational opportunities animation. Defended the idea that the physical recovery - the basis of social optimism and social creativity. Settles integrated approach to social and educational animations to enhance the physical and social activity of the young man, the prevention of social passivity. Provides advanced methods and forms of recreation during the implementation of the animation business. It is proposed to use intensively games, theatrical performances, tourist travel, sporting event.</p