The late diagnosis of double cortex syndrome in a 36-year-old woman with resistant atonic seizures

Subcortical laminar heterotopia (double cortex syndrome) is an orphan disease with an incidence of 1 to 200,000 people in the population. The cause of the disease is mutation of the gene DCX (synonyms: DBCN, XLIS) in chromosome Xq22.3-q23. The type of inheritance is X-linked dominant. Correct diagnosis requires a high degree of skills of a neurologist/epileptologist and a radiologist. The paper describes a clinical case of the late diagnosis of double cortex syndrome in a 36-year-old woman with a long history of resistant atonic seizures and mental retardation

Precast-Monolithic Frame System of Interspecific Application «MKS»

Сборно-монолитные каркасные системы имеют наилучшие показатели по расходу бетона и арматуры на квадратный метр общей площади здания по сравнению с массово возводимыми сегодня монолитными каркасами. Экономическая эффективность достигается за счет использования в сборно-монолитном каркасе предварительно напряженных железобетонных элементов заводского изготовления. В настоящее время новые технологии производства конструкций способом безопалубочного формования на длинных стендах массово замещают традиционный способ изготовления преднапряженных изделий агрегатно-поточным способом. При разработке конструктивных решений сборно-монолитной каркасной системы «МКС» использовались возможности технологии непрерывного безопалубочного формования железобетонных изделий, в которых предусмотрено устройство вырезов, отверстий, углублений для шпонок, петлевых выпусков, выпусков предварительно напряженной арматуры на торцах элементов, добавление сеток косвенного армирования в зоне расположения нижней предварительно напряженной арматуры. Все конструктивные узлы и отдельные элементы в системе «МКС» можно запроектировать на основе существующих нормативных документов. Однако отдельные нормативные документы, по которым осуществляется проектирование сборно-монолитных конструкций, носят либо рекомендательный характер, либо устарели. Некоторые современные методики расчета узлов сборно-монолитного каркаса «МКС» не отражены в нормативных документах, что сдерживает массовое применение, как системы «МКС», так и сборно-монолитного домостроения в целом.Prefabricated monolithic frame systems have the best indicators for the consumption of concrete and reinforcement per square meter of the total area of the building compared to the monolithic frames being massively erected today. Economic efficiency is achieved through the use of factory-made prestressed reinforced concrete elements in a prefabricated monolithic frame. Currently, new technologies for the production of structures by the method of formless molding on long stands are rapidly replacing the traditional method of manufacturing prestressed products by the aggregate-flow method. When developing structural solutions of the prefabricated monolithic frame system «MKS», the possibilities of the technology of continuous formless molding of reinforced concrete products were used, in which the device of cutouts, holes, recesses for dowels, loop releases, releases of prestressed reinforcement at the ends of the elements, the addition of indirect reinforcement grids in the area of the lower prestressed reinforcement is provided. All structural components and individual elements in the «MKS» system can be designed on the basis of existing regulatory documents. However, some regulatory documents, according to which the design of prefabricated monolithic structures is carried out, are either advisory in nature or outdated. Some modern methods of calculating the nodes of the prefabricated monolithic frame «MKS» are not reflected in regulatory documents, which constrains the mass application of both the «MKS» system and the prefabricated monolithic housing construction as a whole

Lightsheet-based flow cytometer for whole blood with the ability for the magnetic retrieval of objects from the blood flow

Detection and extraction of circulating tumor cells and other rare objects in the bloodstream are of great interest for modern diagnostics, but devices that can solve this problem for the whole blood volume of laboratory animals are still rare. Here we have developed SPIM-based lightsheet flow cytometer for the detection of fluorescently-labeled objects in whole blood. The bypass channel between two blood vessels connected with the external flow cell was used to visualize, detect, and magnetically separate fluorescently-labeled objects without hydrodynamic focusing. Carriers for targeted drug delivery were used as model objects to test the device performance. They were injected into the bloodstream of the rat, detected fluorescently, and then captured from the bloodstream by a magnetic separator prior to filtration in organs. Carriers extracted from the whole blood were studied by a number of in vitro methods

Changes to the Fossil Record of Insects through Fifteen Years of Discovery

The first and last occurrences of hexapod families in the fossil record are compiled from publications up to end-2009. The major features of these data are compared with those of previous datasets (1993 and 1994). About a third of families (>400) are new to the fossil record since 1994, over half of the earlier, existing families have experienced changes in their known stratigraphic range and only about ten percent have unchanged ranges. Despite these significant additions to knowledge, the broad pattern of described richness through time remains similar, with described richness increasing steadily through geological history and a shift in dominant taxa, from Palaeoptera and Polyneoptera to Paraneoptera and Holometabola, after the Palaeozoic. However, after detrending, described richness is not well correlated with the earlier datasets, indicating significant changes in shorter-term patterns. There is reduced Palaeozoic richness, peaking at a different time, and a less pronounced Permian decline. A pronounced Triassic peak and decline is shown, and the plateau from the mid Early Cretaceous to the end of the period remains, albeit at substantially higher richness compared to earlier datasets. Origination and extinction rates are broadly similar to before, with a broad decline in both through time but episodic peaks, including end-Permian turnover. Origination more consistently exceeds extinction compared to previous datasets and exceptions are mainly in the Palaeozoic. These changes suggest that some inferences about causal mechanisms in insect macroevolution are likely to differ as well

Lopezus fedtschenkoi

Lopezus fedtschenkoi (McLachlan, 1875) МатериаΛ. *РеспубΛика КаΛмыкия: 1♂, Δаганский р-н, 19 км СВВ с. Артезиан, 45°3.042N / 46°44.944E, поΛупустыня, 30.05.2019.Published as part of Makarkin, V. N., Solodovnikov, A. Yu. & Shchurov, V. I., 2021, New data on Neuropterida from the southern part of the European Russia, pp. 45-49 in Caucasian Entomological Bulletin (Caucas. entomol. bull.) (Caucas. entomol. bull.) 17 (1) on page 48, DOI: 10.23885/181433262021171-454

Neuroleon nemausiensis subsp. piryulini Kryvokhasky 2011

Neuroleon nemausiensis piryulini Kryvokhasky, 2011 МатериаΛ. Астраханская обΛ.: 1♀, берег р. ВоΛга, 46°49.817N / 47°34.744E, на свет, 1.06.2019.Published as part of Makarkin, V. N., Solodovnikov, A. Yu. & Shchurov, V. I., 2021, New data on Neuropterida from the southern part of the European Russia, pp. 45-49 in Caucasian Entomological Bulletin (Caucas. entomol. bull.) (Caucas. entomol. bull.) 17 (1) on page 48, DOI: 10.23885/181433262021171-454

Chrysopa abbreviata Curtis 1834

Chrysopa abbreviata Curtis, 1834 МатериаΛ. РеспубΛика КаΛмыкия: 1♀, р. Ахтуба, 46°49.817N / 44°47.394E, на свет, 2.06.2019.Published as part of Makarkin, V. N., Solodovnikov, A. Yu. & Shchurov, V. I., 2021, New data on Neuropterida from the southern part of the European Russia, pp. 45-49 in Caucasian Entomological Bulletin (Caucas. entomol. bull.) (Caucas. entomol. bull.) 17 (1) on page 48, DOI: 10.23885/181433262021171-454

Chrysoperla carnea, s. l.

Chrysoperla carnea (Stephens, 1836), s. l. МатериаΛ. РеспубΛика КаΛмыкия: 3♂, 1♀, берег р. ЭΛиста, на свет, 46°17.800N / 44°32.061E, 29.05.2019. Астраханская обΛ.: 1♀, берег р. ВоΛга, 46°49.817N / 47°34.744E, на свет, 1.06.2019. ВоΛгограΑская обΛ.: 1♀, окр. оз. ЭΛьтон, 49°12.476N / 46°43.173E, кошение, 4.06.2019. Саратовская обΛ.: 1♀, ХваΛынский Λес (национаΛьный парк «ХваΛынский»), 52°41.978N / 47°93.894E, 9.06.2019.Published as part of Makarkin, V. N., Solodovnikov, A. Yu. & Shchurov, V. I., 2021, New data on Neuropterida from the southern part of the European Russia, pp. 45-49 in Caucasian Entomological Bulletin (Caucas. entomol. bull.) (Caucas. entomol. bull.) 17 (1) on page 48, DOI: 10.23885/181433262021171-454

Wesmaelius navasi

Wesmaelius navasi (Andreu, 1911) МатериаΛ. *РеспубΛика КаΛмыкия: 1♀, пойма р. Ахтуба, 46°49.817N / 44°47.394E, на свет, 2.06.2019. Замечания. Источник света, на который собран изученный экземпΛяр, быΛ выставΛен в сухой степи, непоΑаΛеку от реки, окаймΛенной тростником. Распространение. КсерофиΛьный южнопаΛеарктический виΑ, распространенный от островов МаΑейра и Канарских Αо Внутренней МонгоΛии в Китае [Makarkin, 1996]. В Европе он известен тоΛько на крайнем юге: Испания, острова Крит и МаΛьта, Крым и Северный Кавказ (АΑыгея, Ингушетия) [Ábrahám, 2000; Aspöck et al., 2001; Макаркин, Щуров, 2011]. НахоΑка виΑа в КаΛмыкии, таким образом, самая северная в Европе.Published as part of Makarkin, V. N., Solodovnikov, A. Yu. & Shchurov, V. I., 2021, New data on Neuropterida from the southern part of the European Russia, pp. 45-49 in Caucasian Entomological Bulletin (Caucas. entomol. bull.) (Caucas. entomol. bull.) 17 (1) on page 46, DOI: 10.23885/181433262021171-454

Chrysopa formosa Brauer 1851

Chrysopa formosa Brauer, 1851 МатериаΛ. Астраханская обΛ.: 2♂, берег р. ВоΛга, 46°49.817N / 47°34.744E, на свет, 1.06.2019.Саратовская обΛ.: 1♂, 1♀, ХваΛынский Λес (национаΛьный парк «ХваΛынский»), 52°41.978N / 47°93.894E, 9.06.2019.Published as part of Makarkin, V. N., Solodovnikov, A. Yu. & Shchurov, V. I., 2021, New data on Neuropterida from the southern part of the European Russia, pp. 45-49 in Caucasian Entomological Bulletin (Caucas. entomol. bull.) (Caucas. entomol. bull.) 17 (1) on page 48, DOI: 10.23885/181433262021171-454