72 research outputs found
Wannier functions analysis of the nonlinear Schr\"{o}dinger equation with a periodic potential
In the present Letter we use the Wannier function basis to construct lattice
approximations of the nonlinear Schr\"{o}dinger equation with a periodic
potential. We show that the nonlinear Schr\"{o}dinger equation with a periodic
potential is equivalent to a vector lattice with long-range interactions. For
the case-example of the cosine potential we study the validity of the so-called
tight-binding approximation i.e., the approximation when nearest neighbor
interactions are dominant. The results are relevant to Bose-Einstein condensate
theory as well as to other physical systems like, for example, electromagnetic
wave propagation in nonlinear photonic crystals.Comment: 5 pages, 1 figure, submitted to Phys. Rev.
Prospects in computational molecular medicine: a millennial mega-project on peptide folding
During the second half of the 20th century, Molecular Computations have
reached to a level that can revolutionize chemistry. The next target
will be structural biology, which will be followed soon by Molecular
Medicine. The present paper outlines where we are at, in this field, at
the end of the 20th century, and in what direction the development may
take in the new millennium. In view of the gigantic nature of the
problem, it is suggested that a suitably designed cooperative
Millennial Mega-project might accelerate our schedule. (C) 2000
Elsevier Science B.V. All rights reserved
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-dependent antioxidant signaling by physically interacting with Nrf2 and promoting its stability and activation. BRCA1-deficient mouse primary mammary epithelial cells show low expression of Nrf2-regulated antioxidant enzymes and accumulate reactive oxygen species (ROS) that impair survival in vivo. Increased Nrf2 activation rescues survival and ROS levels in BRCA1-null cells. Interestingly, 53BP1 inactivation, which has been shown to alleviate several defects associated with BRCA1 loss, rescues survival of BRCA1-null cells without restoring ROS levels. We demonstrate that estrogen treatment partially restores Nrf2 levels in the absence of BRCA1. Our data suggest that Nrf2-regulated antioxidant response plays a crucial role in controlling survival downstream of BRCA1 loss. The ability of estrogen to induce Nrf2 posits an involvement of an estrogen-Nrf2 connection in BRCA1 tumor suppression. Lastly, BRCA1-mutated tumors retain a defective antioxidant response that increases the sensitivity to oxidative stress. In conclusion, the role of BRCA1 in regulating Nrf2 activity suggests important implications for both the etiology and treatment of BRCA1-related cancers.FWN – Publicaties zonder aanstelling Universiteit Leide
Measurement of the νe and total 8B solar neutrino fluxes with the Sudbury Neutrino Observatory phase-III data set
This paper details the solar neutrino analysis of the 385.17-day phase-III data set acquired by the Sudbury Neutrino Observatory (SNO). An array of 3He proportional counters was installed in the heavy-water target to measure precisely the rate of neutrino-deuteron neutral-current interactions. This technique to determine the total active 8B solar neutrino flux was largely independent of the methods employed in previous phases. The total flux of active neutrinos was measured to be 5.54-0.31+0.33(stat.)-0.34+0.36(syst.)×106 cm-2 s-1, consistent with previous measurements and standard solar models. A global analysis of solar and reactor neutrino mixing parameters yielded the best-fit values of Δm2=7.59-0.21+0.19×10 -5eV2 and θ=34.4-1.2+1.3degrees
Managing activity costs with flexible budgeting and variance analysis
Accounting Horizons103141-14
’Die Politik von Florence Nightingale in der feministischen Geschichtsschreibung’ [vertaling]
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Factors affecting the characteristics of boards of directors: An empirical study of New Zealand initial public offering firms
Journal of Business Research472147-159JBRE
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