The Electrostatic Ion Beam Trap : a mass spectrometer of infinite mass range

We study the ions dynamics inside an Electrostatic Ion Beam Trap (EIBT) and show that the stability of the trapping is ruled by a Hill's equation. This unexpectedly demonstrates that an EIBT, in the reference frame of the ions works very similar to a quadrupole trap. The parallelism between these two kinds of traps is illustrated by comparing experimental and theoretical stability diagrams of the EIBT. The main difference with quadrupole traps is that the stability depends only on the ratio of the acceleration and trapping electrostatic potentials, not on the mass nor the charge of the ions. All kinds of ions can be trapped simultaneously and since parametric resonances are proportional to the square root of the charge/mass ratio the EIBT can be used as a mass spectrometer of infinite mass range

Clinicians’ perceptions of Norwegian women’s experiences of infertility diseases

Background: Norway has one of the best health systems in the world. However, it has a low birth rate, which decreased by 21.2% between 2009 and 2018, and one of the highest rates of infertility prevalence. The aim of this study is to understand how Norwegian doctors perceive female infertility diseases, namely those that are more difficult to diagnose and to treat, and that are more common in their practice. Method: Descriptive qualitative study was conducted with gynecologists and general practitioners. The sample resulted from the establishment of five criteria and on the doctors’ acceptance to participate in this study. Our sample comprised thirteen highly qualified and experienced doctors. Qualitative content analysis was the method chosen to analyze the collected data. Results: Clinical diseases (polycystic ovary syndrome, endometriosis and vulvodynia) and consequences of these diseases were the pinpointed themes. These led to a set of sub-themes: the main symptoms and the treatment of the diseases, from the perspective of both women and doctors (stigmatization, disturbances in women’s daily life, diagnostic delay, and governmental support). Conclusions: The three most relevant disorders mentioned were polycystic ovary syndrome, endometriosis and vulvodynia. These diseases cause several impacts on the lives of women, because they feel stigmatized and limited in their daily life and sexuality, and the diagnosis of these diseases takes too much time. Governments should better redistribute the financing of women’s health and allocate resources to specialized centers.info:eu-repo/semantics/publishedVersio

The activation energy for GaAs/AlGaAs interdiffusion

Copyright 1997 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. This article appeared in Journal of Applied Physics 82, 4842 (1997) and may be found at

Advanced Directives and Living Will: A Case Report

Descreve-se o caso de uma mulher de 61 anos, com diagnóstico de neoplasia da mama em estadio IV. Na altura, recusou terapêutica. Recorre ao Serviço de Urgência, um ano após o diagnóstico, em mutismo, sendo que os exames complementares de diagnóstico revelaram uma lesão cerebral, interpretada como nova metástase. No seu processo clínico, tem uma diretiva antecipada de vontade. Este é um documento formal que explicita quais os cuidados que pretende ou não receber em final de vida. Apresentamos a descrição do caso, as indicações que a doente deixou expressas neste documento e uma reflexão acerca das diretivas antecipadas de vontade e de como estas devem ser integradas na prática clínica.info:eu-repo/semantics/publishedVersio

Particle Motion in Rapidly Oscillating Potentials: The Role of the Potential's Initial Phase

Rapidly oscillating potentials with a vanishing time average have been used for a long time to trap charged particles in source-free regions. It has been argued that the motion of a particle in such a potential can be approximately described by a time independent effective potential, which does not depend upon the initial phase of the oscillating potential. However, here we show that the motion of a particle and its trapping condition significantly depend upon this initial phase for arbitrarily high frequencies of the potential's oscillation. We explain this novel phenomenon by showing that the motion of a particle is determined by the effective potential stated in the literature only if its initial conditions are transformed according to a transformation which we show to significantly depend on the potential's initial phase for arbitrarily high frequencies. We confirm our theoretical findings by numerical simulations. Further, we demonstrate that the found phenomenon offers new ways to manipulate the dynamics of particles which are trapped by rapidly oscillating potentials. Finally, we propose a simple experiment to verify the theoretical findings of this work.Comment: 9 pages, 8 figures, published in PR

The role of antihydrogen formation in the radial transport of antiprotons in positron plasmas

Simulations of the behaviour of antiprotons in positron clouds during antihydrogen formation.The work added to our understanding of the underlying processes, including the dominant role played by antihydrogen formation itself

Modulation of Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Function by Hypoxia-Upregulated Protein 1

Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these proteins is viral interleukin-6 (vIL-6), which is a homolog of human IL-6 (hIL-6). vIL-6 is able to prevent apoptosis and promote proinflammatory signaling, angiogenesis, and cell proliferation. Although it can be secreted, vIL-6 is mainly an intracellular protein that is retained in the endoplasmic reticulum (ER). We performed affinity purification and mass spectrometry to identify novel vIL-6 binding partners and found that a cellular ER chaperone, hypoxia-upregulated protein 1 (HYOU1), interacts with vIL-6. Immunohistochemical staining reveals that both PEL and KS tumor tissues express significant amounts of HYOU1. We also show that HYOU1 increases endogenous vIL-6 protein levels and that HYOU1 facilitates vIL-6-induced JAK/STAT signaling, migration, and survival in endothelial cells. Furthermore, our data suggest that HYOU1 also modulates vIL-6's ability to induce CCL2, a chemokine involved in cell migration. Finally, we investigated the impact of HYOU1 on cellular hIL-6 signaling. Collectively, our data indicate that HYOU1 is important for vIL-6 function and may play a role in the pathogenesis of KSHV-associated cancers

In vitro sensitivity of Hungarian Actinobaculum suis strains to selected antimicrobials

In vitro antimicrobial sensitivity of 12 Hungarian isolates and the type strain ATCC 33144 of Actinobaculum suis to different antimicrobial compounds was determined both by the agar dilution and by the disc diffusion method. By agar dilution, MIC50 values in the range of 0.05-3.125µg/ml were determined for penicillin, ampicillin, ceftiofur, doxycycline, tylosin, pleuromutilins, chloramphenicol, florfenicol, enrofloxacin and lincomycin. The MIC50 value of oxytetracycline and spectinomycin was 6.25 and 12.5µg/ml, respectively. For ofloxacin, flumequine, neomycin, streptomycin, gentamicin, nalidixic acid, nitrofurantoin and sulphamethoxazole + trimethoprim MIC50 values were in the range of 25-100µg/ml. With the disc diffusion method, all strains were sensitive to penicillin, cephalosporins examined, chloramphenicol and florfenicol, tetracyclines examined, pleuromutilins, lincomycin and tylosin. Variable sensitivity was observed for fluoroquinolones (flumequine, enrofloxacin, ofloxacin), most of the strains were susceptible to marbofloxacin. Almost all strains were resistant to aminoglycosides but most of them were sensitive to spectinomycin. A strong correlation was determined for disc diffusion and MIC results (Spearman's rho 0.789, p<0001). MIC values of the type strain and MIC50 values of other tested strains did not differ significantly. Few strains showed a partially distinct resistance pattern for erythromycin, lincomycin and ampicillin in both methods