The Snowmelt-Runoff Model (SRM) user's manual

A manual to provide a means by which a user may apply the snowmelt runoff model (SRM) unaided is presented. Model structure, conditions of application, and data requirements, including remote sensing, are described. Guidance is given for determining various model variables and parameters. Possible sources of error are discussed and conversion of snowmelt runoff model (SRM) from the simulation mode to the operational forecasting mode is explained. A computer program is presented for running SRM is easily adaptable to most systems used by water resources agencies

Analysis of standing vertical jumps using a force platform

A force platform analysis of vertical jumping provides an engaging demonstration of the kinematics and dynamics of one-dimensional motion. The height of the jump may be calculated (1) from the flight time of the jump, (2) by applying the impulse–momentum theorem to the force–time curve, and (3) by applying the work–energy theorem to the force-displacement curve

Towards Loop Quantization of Plane Gravitational Waves

The polarized Gowdy model in terms of Ashtekar-Barbero variables is further reduced by including the Killing equations for plane-fronted parallel gravitational waves with parallel rays. The resulting constraint algebra, including one constraint derived from the Killing equations in addition to the standard ones of General Relativity, are shown to form a set of first-class constraints. Using earlier work by Banerjee and Date the constraints are expressed in terms of classical quantities that have an operator equivalent in Loop Quantum Gravity, making space-times with pp-waves accessible to loop quantization techniques.Comment: 14 page

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood. It has been assumed that the first identified kinesin - the transport motor kinesin-1 – is the mechanistic paradigm for the entire superfamily, but accumulating evidence suggests that this is not the case. To address the deficits in our understanding of the molecular basis of functional divergence within the kinesin superfamily, we studied kinesin-5s, which are essential mitotic motors whose inhibition blocks cell division. Using cryo-electron microscopy and subnanometer resolution structure determination, we have visualised conformations of microtubule-bound human kinesin-5 motor domain at successive steps in its ATPase cycle. Following ATP hydrolysis, nucleotide-dependent conformational changes in the active site are allosterically propagated into rotations of the motor domain and uncurling of the drugbinding loop L5. In addition, the mechanical neck-linker element that is crucial for motor stepping undergoes discrete, ordered displacements. We also observed large reorientations of the motor N-terminus that indicate its importance for kinesin-5 function through control of neck-linker conformation. A kinesin-5 mutant lacking this N-terminus is enzymatically active, and ATP-dependent neck-linker movement and motility is defective although not ablated. All these aspects of kinesin-5 mechanochemistry are distinct from kinesin-1. Our findings directly demonstrate the regulatory role of the kinesin-5 N-terminus in collaboration with the motor’s structured neck-linker, and highlight the multiple adaptations within kinesin motor domains that tune their mechanochemistries according to distinct functional requirements

Shape in an Atom of Space: Exploring quantum geometry phenomenology

A phenomenology for the deep spatial geometry of loop quantum gravity is introduced. In the context of a simple model, an atom of space, it is shown how purely combinatorial structures can affect observations. The angle operator is used to develop a model of angular corrections to local, continuum flat-space 3-geometries. The physical effects involve neither breaking of local Lorentz invariance nor Planck scale suppression, but rather reply on only the combinatorics of SU(2) recoupling. Bhabha scattering is discussed as an example of how the effects might be observationally accessible.Comment: 14 pages, 7 figures; v2 references adde

Neutralizing antibody response during acute and chronic hepatitis C virus infection

Little is known about the role of Abs in determining the outcome of hepatitis C virus (HCV) infection. By using infectious retroviral pseudotypes bearing HCV glycoproteins, we measured neutralizing Ab (nAb) responses during acute and chronic HCV infection. In seven acutely infected health care workers, only two developed a nAb response that failed to associate with viral clearance. In contrast, the majority of chronically infected patients had nAbs. To determine the kinetics of strain-specific and crossreactive nAb emergence, we studied patient H, the source of the prototype genotype 1a H77 HCV strain. An early weak nAb response, specific for the autologous virus, was detected at seroconversion. However, neutralization of heterologous viruses was detected only between 33 and 111 weeks of infection. We also examined the development of nAbs in 10 chimpanzees infected with H77 clonal virus. No nAb responses were detected in three animals that cleared virus, whereas strain-specific nAbs were detected in six of the seven chronically infected animals after approximately 50 weeks of infection. The delayed appearance of high titer crossreactive nAbs in chronically infected patients suggests that selective mechanism(s) may operate to prevent the appearance of these Abs during acute infection. The long-term persistence of these nAbs in chronically infected patients may regulate viral replication

“CLOCK IN THE ROCK” – IN-SITU C-14 ROCK SURFACE EXPOSURE DATING APPLICATIONS

Cosmic rays interact not only with the atmosphere, but also with material at the surface of the Earth. Thus C-14 can be produced directly in a rock surface by the effect of cosmic-ray neutron effects. The goal of the research is to develop the capability of the Hertelendi Laboratory for Environmental Sciences (HEKAL) in the field of cosmogenic radionuclides produced in situ by the action of cosmic radiation. Our aim is to construct a small line for the extraction of cosmogenic C-14 from quartz, making a system compatible with the online capabilities of the new MICADAS accelerator mass spectrometer (AMS) at HEKAL in Debrecen. We have tested the chemical blank level, cross contamination effect and reproducibility of MICADAS gas ion source application in in-situ rock surface exposure dating