Measured non-transformed cytokine values as median and inter-quartile range (pg/mL).

<p>Measured non-transformed cytokine values as median and inter-quartile range (pg/mL).</p

Cytokines associated with CLI when compared to IC.

<p>Forest plot illustrating the findings of multivariable modeling. The ratio value indicates that there is an independent 8% (95% CI, 1–16%) increase in the level of IL-1β associated with the presence of critical ischemia, an independent 15% (95% CI, 6–25%) increase in the level of IL-1ra in the presence of CLI, an independent 11% (95% CI, 2–20%) increase the level of IL-2 associated with the presence of critical ischemia etc.</p

Baseline characteristics.

<p>Baseline characteristics.</p

Soluble CD73 concentrations (ng/mL) according to the 90-day survival.

<p>Soluble CD73 concentrations (ng/mL) according to the 90-day survival.</p

Soluble CD73 concentrations (ng/mL) according to the presence/development of acute kidney injury (AKI).

<p>Soluble CD73 concentrations (ng/mL) according to the presence/development of acute kidney injury (AKI).</p

Univariate and multivariable logistic regression models for 90-day mortality.

<p>Univariate and multivariable logistic regression models for 90-day mortality.</p

Box-plots presenting sCD73 levels according to the severity of sepsis at the time of sampling.

<p>The figure is truncated at level 30 ng/mL level excluding 51 (3.3%) of the cases (range in values 0.47 to 220.59 ng/mL). ICU; intensive care unit. Comparisons: ICU admission: severe sepsis (n = 300) vs. septic shock (n = 190) <i>P</i> = 0.158; no sepsis (n = 98) vs. severe sepsis, P = 0.08; no sepsis vs. septic shock <i>P</i> = 0.011, across all three groups <i>P</i> = 0.031. 24H: severe sepsis (n = 172) vs. septic shock (n = 404) <i>P</i> = 0.039; no sepsis (n = 12) vs. severe sepsis, p = 0.980; no sepsis vs. septic shock P = 0.593; across all three groups <i>P</i> = 0.196. Day 3: severe sepsis (n = 34) vs. septic shock (n = 98) <i>P</i> = 0.014. Day 5: severe sepsis (n = 44) vs. septic shock (n = 180) <i>P</i> = 0.086.</p

Univariate and multivariable logistic regression models for the development of AKI.

<p>Univariate and multivariable logistic regression models for the development of AKI.</p

Study flow chart ICU; intensive care unit.

<p>Study flow chart ICU; intensive care unit.</p

Soluble CD73 concentrations (ng/mL) according to the presence/development of acute kidney injury (AKI).

<p>Soluble CD73 concentrations (ng/mL) according to the presence/development of acute kidney injury (AKI).</p