Associations between Supper Timing and Mortality from Cardiovascular Disease among People with and without Hypertension

Inui, Tomoki, Sakaniwa, Ryoto, Shirai, Kokoro, et al. Associations between Supper Timing and Mortality from Cardiovascular Disease among People with and without Hypertension : . Journal of Atherosclerosis and Thrombosis advpub, (2024); https://doi.org/10.5551/jat.64192 .Aim: Less is known about the impact of supper time on cardiovascular disease (CVD) risk among hypertensives and nonhypertensives. We aimed to explore this issue in a cohort study. Methods: We analyzed the data of 72,658 participants (15,386 hypertensives and 57,272 nonhypertensives) aged 40–79 years without a history of CVD at baseline (1988–1990) under the Japan Collaborative Cohort study. Supper time was assessed based on self-reported questionnaires categorized as before 17:00, between 17:00 and 20:00, after 20:00, irregular supper time, and reference supper time (17:00–20:00). Hazard ratios (HRs) and 95% confidence intervals (95% CI) of CVD mortality were calculated according to supper time after adjustment for potential confounders, stratified by hypertensive status and age group (＜65 and ≥ 65 years).Results: During a median of 19.4 years of follow-up, 4,850 CVD deaths were recorded. Compared with the reference time, the risk of CVD mortality was higher for irregular supper time for the total population, either hypertensives or nonhypertensives, more specifically hypertensives aged ≥ 65 years; the multivariable HR (95% CI) of CVD mortality in the total population was 1.28 (1.11–1.50, P＜0.01). The supper time of ＞20:00 tended to be associated with the higher risk only for hypertensives; the multivariable HR was 1.39 (0.98–1.96, P=0.06). Conclusion: Irregular supper time was associated with an increased risk of CVD mortality. Supper timing could be a surrogate marker for CVD risk

Self-Association Behavior of Cell Membrane-Inspired Amphiphilic Random Copolymers in Water

Water-soluble and amphiphilic random copolymers (P(MPC/DMAx)) composed of hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) and hydrophobic n-dodecyl methacrylate (DMA) were prepared via reversible addition-fragmentation chain transfer (RAFT) controlled radical polymerization. The compositions of DMA unit (x) in the copolymer were in the range of 0 to 38 unit mol %. The degree of polymerization of P(MPC/DMAx) was adjusted to about 200. Since the monomer reactivity ratios of MPC and DMA are 1.01 and 1.00, respectively, ideal free radical copolymerization occurred. In aqueous solutions, interpolymer aggregation occurred due to the hydrophobic pendant n-dodecyl groups. The aggregation number (Nagg) increased with an increasing x. The mobilities of the DMA and MPC pendant groups in aqueous solutions were restricted, as confirmed by 1H NMR relaxation time measurements, because a part of the MPC units were trapped in the hydrophobic microdomain formed from the pendant n-dodecyl groups. The polarity of the hydrophobic microdomain formed from P(MPC/DMA38) in water was similar to that of ethyl acetate according to fluorescence probe experiments. No specific interactions were found in water between P(MPC/DMAx) and bovine serum albumin because the surface of the interpolymer aggregates contained only hydrophilic MPC units

Relationships of habitual daily alcohol consumption with all-day and time-specific average glucose levels among non-diabetic population samples

Background: Alcohol consumption is a prevalent behavior that is bi-directionally related to the risk of type 2 diabetes. However, the effect of daily alcohol consumption on glucose levels in real-world situations in the general population has not been well elucidated. This study aimed to clarify the relationship between alcohol consumption and all-day and time-specific glucose levels among non-diabetic individuals. Methods: We investigated 913 non-diabetic males and females, aged 40–69 years, during 2018–2020 from four communities across Japan. The daily alcohol consumption was assessed using a self-report questionnaire. All-day and time-specific average glucose levels were estimated from the interstitial glucose concentrations measured using the Flash glucose monitoring system for a median duration of 13 days. Furthermore, we investigated the association between all-day and time-specific average glucose levels and habitual daily alcohol consumption levels, using never drinkers as the reference, and performed multiple linear regression analyses after adjusting for age, community, and other diabetes risk factors for males and females separately. Results: All-day average glucose levels did not vary according to alcohol consumption categories in both males and females. However, for males, the average glucose levels between 5:00 and 11:00 h and between 11:00 and 17:00 h were higher in moderate and heavy drinkers than in never drinkers, with the difference values of 4.6 and 4.7 mg/dL for moderate drinkers, and 5.7 and 6.8 mg/dL for heavy drinkers. Conversely, the average glucose levels between 17:00 and 24:00 h were lower in male moderate and heavy drinkers and female current drinkers than in never drinkers; the difference values of mean glucose levels were −5.8 for moderate drinkers, and −6.1 mg/dL for heavy drinkers in males and −2.7 mg/dL for female current drinkers. Conclusions: Alcohol consumption was associated with glucose levels in a time-dependent biphasic pattern