Inappropriate prescribing in hospitalized elderly patients

Inappropriate prescribing (IP) is a major healthcare problem in elderly patients. The risk of this problem increases during hospitalization. This is due to increase morbidity and thus increases the use of medications by the inpatients. This study will clarify the problem of IP for elderly people during hospitalization and will identify the different types of it. It also will highlight some tools that are used to assess the different types of IP and the prevalence of it in elderly patients during hospitalization. Finally, the study will address the consequences of IP in the elderly inpatients and the risks associated with the use of some potentially inappropriate medications (PIMs) in the elderly.

Evaluation of inappropriate prescribing to the hospitalized elderly patients in Al Shifa hospital, Gaza, Palestine

Background: The current study aimed to assess the prevalence of inappropriate prescribing (IP) for hospitalized elderly patients at Al Shifa Hospital, Gaza, Palestine.Methods: This study was a retrospective cross-sectional study. A total of 2385 prescribed drugs for 380 elderly inpatients in internal, cardiology, and respiratory departments were screened for IP. Four criteria were used to detect IP using chart review method; Drug-drug interactions (DDIs), drug contra-indications (CI), duplication of therapy and Beers' criteria 2012.Results: The results showed that 44.2% of patients had at least one IP. Around 33.2% of the patients had DDIs, 19.2% had IP according to Beers' criteria and 1.1% had drug CI. There was no duplication of therapy. A total of 323 IP instances were detected. Of them, 74% for DDIs and 24.8% for Beers' criteria. The prevalence of overall IP was significantly influenced by age (p-value=0.024), polypharmacy (p-value<0.001), degree of morbidity (p-value<0.001), and departments (p-value=0.018). The prevalence of DDIs was influenced by polypharmacy (p-value<0.001), degree of morbidity (p-value=0.001), and departments (p-value=0.005). Finally, the prevalence of IP according to Beers' criteria was significantly influenced by departments with the highest in the cardiology department (29.7%) (P-value=0.007).Conclusions: Although the overall IP was common, it was not far higher than that reported worldwide. The majority of IP was DDIs. Age, polypharmacy, degree of morbidity and departments influenced the occurrence of IP

Internet law

This paper aims to illustrate the basis of cyberspace law and its potential environment. Indeed, the laws governing the cyberspace are still premature at both national and international levels. This is due to the undefined nature of cyber borders that globalize the Internet in contradiction with the geographic borders. Hence, individual countries are losing part of their sovereignty as result of globalization of the internet to a point it is becoming a borderless space with no laws and regulations. This urges to agree on new international legislations to handle any acts that are not confined by geographical borders or any obstructing matters. Given the fact that the cyberspace does not have such boundaries, it is not realistic to stop all the activities of electronic crimes or other harmful activities. In addition, it is challenging to define viable means to face such threats by individuals, organizations or countries. It is believed that subjecting the internet to the law may contradict with freedom and democracy. Nonetheless, subjecting the internet to the law under democratic approach can result in an effective means for exchanging information and culture among people around the world. Although it is impossible to fully prevent the occurrence of cyberspace risks and predict the potential threats on the countries communication and information systems, this research provides answers to a number of questions on how to achieve the protection of public order, whether domestic or international, from criminal cyberspace threats. The research paper is divided into two sections as follows: 1. Legislative and regulatory framework of cyberspace Law. Sources of cyberspace La

Identifying effluents from a food processing industry

The agri-food industry in Morocco generates significant volumes of liquid waste, contributing to environmental challenges that directly impact public health. To address this issue, it is crucial to characterize this wastewater comprehensively, enabling the development of suitable treatment strategies to alleviate pollution and potentially facilitate recycling. This study focuses on the identification of effluents from an olive and caper preservation industry, employing physicochemical and bacteriological analyses on raw, decanted, and filtered effluent samples. The findings reveal that the effluent from the olive and caper preservation industry is characterized by high acidity and an exceptionally elevated mineral load. Notably, the application of decantation and filtration methods demonstrates a limited influence, primarily affecting the reduction of suspended solids. Understanding these physicochemical and bacteriological characteristics is pivotal for devising targeted treatment protocols, ensuring effective pollution reduction, and exploring avenues for potential recycling of this agri-food industry wastewater. This research serves as a foundation for informed decision-making in the development of sustainable and efficient wastewater management practices, balancing environmental preservation with industrial needs

CTGA: the database for genetic disorders in Arab populations

The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the ‘Catalogue of Transmission Genetics in Arabs’ (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA ()

Design, synthesis, antitumor activity and molecular docking study of novel 5-deazaalloxazine analogs

open access articleProtein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein, we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted alkylamino), 2-(heterocyclic substituted), 2-amino, 2,4-dioxo and 2-deoxo-5-deazaalloxazine derivatives by applying structure-based drug design (SBDD) using AutoDock 4.2. Their antitumor activities against human CCRF-HSB-2, KB, MCF-7 and HeLa have been investigated in vitro. Many 5-deazaalloxazine analogs revealed high selective activities against MCF-7 tumor cell lines (IC50: 0.17–2.17 µM) over HeLa tumor cell lines (IC50 > 100 µM). Protein kinase profiling revealed that compound 3h induced multi- targets kinase inhibition including −43% against (FAK), −40% against (CDKI) and −36% against (SCR). Moreover, the Annexin-V/PI apoptotic assay elucidate that compound 3h showed 33% and potentially 140% increase in early and late apoptosis to MCF-7 cells respectively, compared to the control. The structure-activity relationship (SAR) and molecular docking study using PTK as a target enzyme for the synthesized 7-deazaalloaxazine derivatives were investigated as potential antitumor agents. The AutoDock binding affinities of the 5deazaalloxazine analogs into c-kit PTK (PDB code: 1t46) revealed reasonable correlations between their AutoDock binding free energy and IC50

Detection of Herpes Viruses in Aggressive Periodontitis Patients in Mosul

The aim of the study is to estimate the frequency of herpes viruses HCMV, EBV1 and HSV in periodontal pocket samples of aggressive periodontitis patients. This study was carried out on total number of 24 Aggressive Periodontitis patients, 14 (58%) males and 10 (42%) females, aging between 20-?40 years old). Periodontal pocket samples were collected from three deepest pocket sites and nested PCR technique was used to detect HCMV, EBV and HS

Serum and Salivary Markers in Aggressive Periodontitis Patients In Mosul

This study also showed direct correlation between serum IL-1? and Salivary peroxidase, also between (IgA, total protein and peroxidase Specific activity in saliva). Finally presence of direct correlation between peroxidase specific activity and total protein. The aims of the study is to assess and compare serum levels of cytokines (IL-8,IL-6,IL-1?,IFN-? and TNF-?) and salivary markers (sIgA, peroxidase, peroxidase specific activity and total protein) in aggressive periodontitis patients and periodontally healthy individuals in Mosul. This study was carried out on a total number of 49 subjects, 24 Aggressive Periodontitis patients,14 males and 10 females, aging between 20 - ?40 years, and 25 healthy subjects as control group which consisted of 14 males and 11 females aging between 20-45 years. All patients were systemically healthy. Five ml of venous blood and saliva were withdrawn from each patient and control subject, for assessments of serum cytokines (IL-8,IL-6,IL-1?,IFN-? and TNF-? ) and salivary markers (sIgA, total protein and peroxidase specific activity) usin

Application of the fuzzy analytic hierarchy process for water resources in the Wadi AlHasa catchment, Jordan

This article introduces a groundwater vulnerability assessment model that utilises the fuzzy analytic hierarchy process (FAHP) in the Wadi AlHasa catchment, Jordan. The assessment takes into account both geomorphological and hydrogeological variables, employing a comprehensive methodology that integrates various parameters. To evaluate the catchment, the study employs remote sensing and Geographic Information System (GIS) techniques. The analysis of the digital elevation model enables the creation of a map illustrating the diverse geomorphology of the catchment. This geomorphology significantly influences drainage density, direction, and the spatial distribution and intensity of flash flood events. Moreover, the study develops and maps a fuzzy FAHP DRASTIC vulnerability index, which proves to be a valuable tool for assessing the susceptibility of groundwater resources to contamination. The unique feature of the index is its ability to incorporate uncertain or subjective data, providing a means to evaluate the significance of various influencing factors. This information serves as critical support for decision-making and management efforts geared towards safeguarding and enhancing groundwater resources. Within the study area, the DRASTIC vulnerability index values span from 0.08325 to 0.28409, with 18% of the site exhibiting a high vulnerability rate. Additionally, the article implements a managed aquifer recharge model (MAR), with 31% of the area falling into MAR classes. Among these, 22.1% are classified as a high MAR class, while 0.7% belong to a very high MAR class. These findings underscore the feasibility of MAR projects in regions with limited water resources

Bioactive chemical constituents of Curcuma longa L. rhizomes extract inhibit the growth of human hepatoma cell line (HepG2)

The present study was designed to identify the chemical constituents of the methanolic extract of Curcuma longa L. rhizomes and their inhibitory effect on a hepatoma cell line. The methanolic extract was subjected to GC-MS analysis to identify the volatile constituents and the other part of the same extract was subjected to liquid column chromatographic separation to isolate curcumin. The inhibition of cell growth in the hepatoma cell line and the cytopathological changes were studied. GC-MS analysis showed the presence of fifty compounds in the methanolic extract of C. longa. The major compounds were ar-turmerone (20.50 %), β-sesquiphellandrene (5.20 %) and curcumenol (5.11 %). Curcumin was identified using IR, 1H and 13C NMR. The inhibition of cell growth by curcumin (IC50 = 41.69 ± 2.87 µg mL–1) was much more effective than that of methanolic extract (IC50 = 196.12 ± 5.25 µg mL–1). Degenerative and apoptotic changes were more evident in curcumin-treated hepatoma cells than in those treated with the methanol extract. Antitumor potential of the methanolic extract may be attributed to the presence of sesquiterpenes and phenolic constituents including curcumin (0.051 %, 511.39 µg g–1 dried methanol extract) in C. longa rhizomes