The lexicographic treatment of the demonstrative copulative in Sesotho sa Leboa — an exercise in multiple cross-referencing

In this research article an in-depth investigation is presented of the lexicographic treatment of the demonstrative copulative (DC) in Sesotho sa Leboa. This one case study serves as an example to illustrate the so-called 'paradigmatic lemmatisation' of closed-class words in the African languages. The need for such an approach follows a discussion, in Sections 1 and 2 respectively, of the present and missing directions in African-language metalexicography. A theoretical conspectus of the DC in Sesotho sa Leboa is then offered in Section 3, while Section 4 examines the treatment of the DC in the four existing desktop dictionaries for this language. The outcomes from the two latter sections are then used in Section 5, which analyses the problems of and options for a sound lexicographic treatment of the DC in bilingual and monolingual dictionaries. The next two sections proceed with a review of the practical implementation of the DC lemmatisation suggestions in PyaSsaL, i.e. the Pukuntšutlhaloši ya Sesotho sa Leboa 'Explanatory Sesotho sa Leboa Dictionary' — with Section 6 focussing on the hardcopy and Section 7 on the online version. In the process, the very first fully monolingual African-language dictionary on the Internet is introduced. Section 8, finally, concludes briefly. Keywords: lexicography, paradigmatic lemmatisation, african languages, sesotho sa leboa (northern sotho, sepedi), demonstrative copulative, cross-referencing, corpus, monolingual dictionary, bilingual dictionar

Gene and cell therapy in South Africa: Current status and future prospects

South Africa has a high disease burden resulting from communicable and non-communicable diseases. Current therapeutic interventions rarely result in a cure and the associated lifelong treatment places a considerable strain on an overburdened health sector. Gene and cell therapies present novel alternatives to disease management, offering the promise of a single treatment and a lifelong cure. Although challenges remain, investment in the field has started to bear fruit, with a number of gene and cell therapeutics reaching the market in the past decade. To take full advantage of these developments, it is important that a proactive approach to nurturing appropriate human and material resources is adopted in the country

Protecting participants in health research: The South African Material Transfer Agreement

The need to transfer human biological materials (HBMs) across national boundaries has become increasingly important in view of increased biobank and commercial activities globally. In light of South Africa (SA)’s history of colonisation and racial discrimination, coupled with well-known instances of exploitation of research participants in the developing world, it is critical that the management of HBMs from and to other jurisdictions is explored and regulated. Material transfer agreements (MTAs) represent an important point of departure in such a process. This article explores the need for a uniform MTA in SA and discusses some aspects of the recently gazetted national MTA, which provides a framework that can serve as a safeguard for cross-border transfer of HBMs in the absence of the National Health Act’s chapter 8 regulations in this regard

Protecting participants in health research: The South African Material Transfer Agreement

The need to transfer human biological materials (HBMs) across national boundaries has become increasingly important in view of increased biobank and commercial activities globally. In light of South Africa (SA)’s history of colonisation and racial discrimination, coupled with well-known instances of exploitation of research participants in the developing world, it is critical that the management of HBMs from and to other jurisdictions is explored and regulated. Material transfer agreements (MTAs) represent an important point of departure in such a process. This article explores the need for a uniform MTA in SA and discusses some aspects of the recently gazetted national MTA, which provides a framework that can serve as a safeguard for cross-border transfer of HBMs in the absence of the National Health Act’s chapter 8 regulations in this regard

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance against the multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity and were addressed through structure–activity and structure–property relationship studies. Pharmacokinetic properties were assessed in mice for compounds showing desirable in vitro activity, a selectivity window over cytotoxicity, and microsomal metabolic stability. Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rγnull (NSG) mouse model. Preliminary mechanistic studies suggest inhibition of hemozoin formation as a contributing mode of action

Research careers of Y-rated researchers in South Africa: Evaluation, support and obstacles

No Abstract.South African Journal of Higher Education Vol. 22 (2) 2008: pp. 348-36

Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles

Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial activity against Plasmodium falciparum and are widely used as scaffolds for metal-based drug research. Incorporating substituents with various lipophilic and electronic properties can influence trans-membrane interactions and concomitantly improve the biological activity. To study structure-activity relationships, a series of 2-phenylbenzimidazoles and their corresponding Ru(II), Ir(III) and Rh(III) cyclometallated complexes were synthesised and evaluated for antiplasmodial activity against the chloroquine-sensitive (NF54) strain of the human malaria parasite Plasmodium falciparum. Selected metal complexes were further screened against the multidrug-resistant (K1) strain. In general, the 2-phenylbenzimidazole ligands showed weak antiplasmodial activities (IC50 ∼ 17.66–22.32 μM) while an enhancement of antiplasmodial activity was observed upon coordination of the ligands with either ruthenium, iridium or rhodium. The new cyclometallated complexes were found to be active against both parasite strains, with IC50 values in the low to submicromolar range (0.12–5.17 μM). In addition, the metal complexes have relatively low cytotoxicity against mammalian Chinese Hamster Ovarian (CHO) cells

RNP and Lewis RNP for all 14 natural tensor norms of Grothendieck

We classify all 14 natural tensor norms of Grothendieck according to the possession of the lack of the Radon-Nikodym property (RNP) and the Lewis Radon-Nikodym property.http://www.tandfonline.com/loi/tqma20nf201