Vitamin B₁₂ Catalyzed Atom Transfer Radical Addition

Vitamin B₁₂, a natural Co-complex, catalyzes atom transfer radical addition (ATRA) of organic halides to olefins. The established conditions were found to be very selective, with atom transfer radical polymerization (ATRP) occurring only in the case of acrylates

Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators

Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B₁₂ derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)₂Cbi

Photoinduced Vitamin B₁₂-Catalysis for Deprotection of (Allyloxy)­arenes

Vitamin B₁₂ is a natural cobalt complex that, while reduced to the “supernucleophilic” Co­(I) form, can easily react with electrophiles via an S_N2 mechanism. It is also shown to react via an S_N2′ mechanism with allylic compounds allowing for photochemical deprotection of (allyloxy)­arenes. A sustainable alternative to commonly used noble metal-catalyzed deprotection reactions is presented