3 research outputs found
Vitamin B<sub>12</sub> Catalyzed Atom Transfer Radical Addition
Vitamin B<sub>12</sub>, a natural Co-complex, catalyzes atom transfer
radical addition (ATRA) of organic halides to olefins. The established
conditions were found to be very selective, with atom transfer radical
polymerization (ATRP) occurring only in the case of acrylates
Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators
Herein, the synthesis of novel hydrophobic and hydrophilic
cobinamides
via aminolysis of vitamin B<sub>12</sub> derivatives that activate
soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators,
they target the catalytic domain of sGC and show higher activity than
(CN)<sub>2</sub>Cbi
Photoinduced Vitamin B<sub>12</sub>-Catalysis for Deprotection of (Allyloxy)arenes
Vitamin B<sub>12</sub> is a natural
cobalt complex that, while
reduced to the “supernucleophilic” Co(I) form, can easily
react with electrophiles via an S<sub>N</sub>2 mechanism. It is also
shown to react via an S<sub>N</sub>2′ mechanism with allylic
compounds allowing for photochemical deprotection of (allyloxy)arenes.
A sustainable alternative to commonly used noble metal-catalyzed deprotection
reactions is presented