The effect of the treatment of denture related stomatitis on peripheral T cells and monocytes

Purpose: Systemic immune activation has been recently linked to chronic inflammatory disorders of the oral cavity, particularly to periodontitis. The purpose of this study was to determine whether treatment of a fungus-induced oral inflammation, namely denture-related stomatitis (DRS), can affect the activation of the systemic immune response. Materials and Methods: Peripheral blood from patients with denture-related stomatitis caused by Candida albicans infection (n = 15) was collected at three time points: before treatment with nystatin, at the end of therapy and 2 months after finishing therapy. Activation of T cells and monocytes was assessed by flow cytometry. Results: The percentages of peripheral lymphocytes, T cells and their subpopulations, as well as monocytes were similar before, immediately following and two months after nystatin treatment. Cells expressing early activation marker CD69 and RANTES C-C chemokine receptor type 5 significantly increased immediately after treatment and returned to baseline levels after two months. Th17 cells, which have been implicated in the pathogenesis of DRS, remained unchanged. Central memory CD4+ subset and intermediate subset of monocytes were lower after therapy and this effect was sustained for two months. Conclusion: Treatment of denture-related stomatitis does not seem to affect the general state of the cellular components of the immune system. The results suggest a potential proinflammatory effect of the antifungal agent, nystatin. Although transient and not intense, this effect might be of particular clinical importance, because of relationships between inflammation and certain diseases. Further studies are required to clarify this aspect

The effect of bromination of carbon fibers on the coefficient of thermal expansion of graphite fiber-epoxy composites

To examine the effect of bromination of carbon fibers on the coefficient of thermal expansion (CTE) of carbon fiber epoxy composites, several pristine and brominated carbon fiber-epoxy composite samples were subjected to thermomechanical analysis. The CTE's of these samples were measured in the uniaxial and transverse directions. The CTE was dominated by the fibers in the uniaxial direction, while it was dominated by the matrix in the transverse directions. Bromination had no effect on the CTE of any of the composites. In addition, the CTE of fiber tow was measured in the absence of a polymer matrix, using an extension probe. The results from this technique were inconclusive

Acute Coronary Syndrome Treatment Cost Estimation in Selected Health Care Units in Poland – Pilot Survey Results

Background: The circulatory system diseases are one of biggest health problems which still pose a fundamental cause of mortality in developed countries. Among those illnesses important place takes myocardial ischemia. Aim: The main purpose of this article is to evaluate hospitalization costs of a patient with acute coronary syndrome in health care units conducting diagnostic and surgery (coronarography and PTCA) as well as in health centres, where patients are treated exclusively pharmacologically. Methods: There has been prepared and used author\u27s individual questionnaire enabling estimation of both fixed and variable treatment costs per patient. In economic analysis there have been used micro-costing principle, defining every element of used supplies and calculating unit cost. Results: The analysis has shown that fixed costs of one hospitalized patient in a clinic equipped in hemodynamics laboratory are only 33% of all costs. In hospitals which did not carry out surgeries, variable costs (e.g. medicines) were respectively lower, whereas fixed costs were up to 72% of total treatment costs. A great impact on level of costs had two risk factors: smoking tobacco and hypercholesterolemia. Conclusions: Increasing number of carried out angioplasty, raises total treatment costs of acute coronary syndrome. Over half of all hospitalization costs of one patient with myocardial ischemia in hospitals not equipped in hemodynamics laboratories determines for fixed costs

Discourses as units of knowledge in the light of neural language models. Refinement of the theory of discursive space

[EN] In recent years, and even months, a rapid development of NLP solutions can be observed. This technology allows one to define deeper semantic inferences in the text based on the idea of neural language models (NLMs). Neural language models (NLMs) are containers of knowledge. The relationship between language and knowledge has been extensively reflected in research in the form of the so-called discourse analysis. Based on Michel Foucault's concept of discourse, especially the text from 1971(Foucault, 1971), knowledge model was proposed named discursive space, in which discourses as instances of knowledge travel trajectories in a multidimensional dynamical space (Maciag, 2022). The idea presented in the paper assumed that it is possible to isolate semantic structures more complex than the semantic units used so far, i.e. tokens, which are based on words and their relationships in sentences. Such structures are discourses, i.e. linguistic (semantic) structures with a higher degree of abstraction than the sentences they consist of. Therefore, one should search for higher-order units (discourses) composed of lower-order semantic units (words) and their relations in sentences. It would be a repetition of the embedding technique used in NLM, but transferred to a higher semantic level, the aim of which is to create a set of vectors describing discourses. By analyzing the mutual position of the indicated discourses in the corpus of texts, a discursive linguistic model would be created. The introduction of a variable in the form of time, i.e. the construction of a dynamical discursive model, would fulfill the assumptions of discursive space.Maciag, R. (2023). Discourses as units of knowledge in the light of neural language models. Refinement of the theory of discursive space. Editorial Universitat Politècnica de València. 99-100. http://hdl.handle.net/10251/2017129910

Effects of sequential treatment with fluorine and bromine on graphite fibers

Three pitch based graphite fibers with different degrees of graphitization and one polyacryonitrile (PAN) based carbon fiber from Amoco Corporation were treated with 1 atm, room temperature fluorine gas for 90 hrs. Fluorination resulted in higher electrical conductivity for all pitch fibers. Further bromination after ambient condition defluorination resulted in further increases in electrical defluorination conductivity for less graphitized, less structurally ordered pitch fibers (P-55) which contain about 3% fluorine by weight before bromination. This product can be stable in 200 C air, or 100% humidity at 60 C. Due to its low cost, this less graphitized fiber may be useful for industrial application, such as airfoil deicer materials. The same bromination process, however, resulted in conductivity decreases for fluorine rich, more graphitized, structurally oriented pitch fibers (P-100 and P-75). Such decreases in electrical conductivity were partially reversed by heating the fibers at 185 C in air. Differential scanning calorimetric (DSC) data indicated that the more graphitized fibers (P-100) contained BrF3, whereas the less graphitized fibers (P-55) did not

Exact, E=0, Solutions for General Power-Law Potentials. I. Classical Orbits

For zero energy, $E=0$, we derive exact, classical solutions for {\em all} power-law potentials, $V(r)=-\gamma/r^\nu$, with $\gamma>0$ and $-\infty <\nu<\infty$. When the angular momentum is non-zero, these solutions lead to the orbits $\r(t)= [\cos \mu (\th(t)-\th_0(t))]^{1/\mu}$, for all $\mu \equiv \nu/2-1 \ne 0$. When $\nu>2$, the orbits are bound and go through the origin. This leads to discrete discontinuities in the functional dependence of $\th(t)$ and $\th_0(t)$, as functions of $t$, as the orbits pass through the origin. We describe a procedure to connect different analytic solutions for successive orbits at the origin. We calculate the periods and precessions of these bound orbits, and graph a number of specific examples. Also, we explain why they all must violate the virial theorem. The unbound orbits are also discussed in detail. This includes the unusual orbits which have finite travel times to infinity and also the special $\nu = 2$ case.Comment: LaTeX, 27 pages with 12 figures available from the authors or can be generated from Mathematica instructions at end of the fil

Regulation and effector functions of IFNgamma-induced immunity to intracellular pathogens

Macrophages are professional phagocytes that efficiently clear microbes, dying cells, and debris. Nonetheless, some pathogenic bacteria and parasites can subvert the macrophage phagosome into a vacuolar replicative niche. Exogenous macrophage activation by the cytokine interferon gamma (IFNγ) tips the equilibrium toward pathogen restriction, host survival, and subsequent adaptive immune responses. The relevance of IFNγ-induced immunity to human health has been demonstrated in patients with genetic defects in IFNγ signaling, who are profoundly susceptible to vacuolar pathogens such as Mycobacterium tuberculosis. Still, much remains to be discovered about IFNγ effector functions, and about their co-regulation by signaling downstream of the many innate immune sensors in macrophages. First, we asked whether IFNγ-induced vesicle trafficking mechanisms affect the maturation of phagosomes containing the bacterium Legionella pneumophila, the causative agent of Legionnaire's disease. We used functional genetic screening to discover candidate genes involved. From 380 genes in a curated vesicle trafficking-related set, 15 were selected as candidate IFNγ pathway members by RNAi screening in cell line and primary mouse macrophages. Functional validation of top candidates was inconclusive, but revealed potential roles for membrane tetraspanins and the AP3 complex in IFNγ-induced microbial restriction. Our second goal was to determine whether innate immune sensing affects IFNγ-induced bacterial restriction. Using macrophages from mice deficient in key elements of innate immune sensing pathways, we discovered that the antiviral transcription factor IRF3, which functions downstream of many nucleic acid sensing pathways, suppresses IFNγ-induced restriction of L. pneumophila and the protozoan parasite Trypanosoma cruzi. While activated IRF3 localizes to the nuclei in resting macrophages infected with L. pneumophila, it is mostly excluded from nuclei in macrophages activated with IFNγ prior to infection. This suggests a cascade of suppression in which IFNγ responses inhibit IRF3 activation, but residual IRF3 activity antagonizes IFNγ effectors. IRF3-mediated inhibition of IFNγ-inducible nitric oxide synthase was partially, but incompletely responsible for the phenotype observed; further candidate effectors were identified by gene expression profiling. We speculate that antagonism between IFNγ and IRF3-mediated mechanisms may facilitate a balance of vacuolar pathogen immunity with viral defense, or with protection of tissue damage by nitric oxide and other IFNγ-dependent responses