Allergy as a factor in idiopathic epilepsy

Two cases of idiopathic epilepsy are reported. In the first, epileptic convulsions disappeared completely during an acute infection and the patient's mental condition showed a remarkable improvement. In the second, after an acute febrile illness in 1931, the patient has since had only two fits. His mental condition shows a very striking improvement.Protein skin tests were performed on twenty -five male patients suffering from idiopathic epilepsy and on twenty -five non -epileptic controls. Among the former, 36% were positive, among the latter, 4%. Sensitiveness, as indicated by positive skin reactions was found to be increased before, and diminished, for a variable period after a fit or series of fits. A few hours after an injection of Pyrifer, it had disappeared. completely.Non -specific desensitisation by means of Pyrifer was attempted in the case of those showing multi- sensitivity. All showed definite mental improvement. In two cases the fits were reduced by 50% and 38% respectively, while in the third case, there was no reduction in the number of fits.Of those treated with Peptone, two improved mentally, while the third showed no noticeable improvement. The effect on the incidence of fits was not so striking as in the case of Pyrifer.The essential features of Allergy are outlined.Evidence is adduced in support of the view that Allergy is a factor in the causation of certain cases of essential Epilepsy.Other methods of treatment are briefly described.The writer urges the investigation of all cases of idiopathic epilepsy from the allergic point of view and the carrying out of protein skin tests. He strongly advocates some form of desensitisation treatment in those cases which appear to have an allergic basis

Dumpor\u27s Case: Its Status

Dumpor\u27s Case holds, according to the syllabus in Sir Edward Coke\u27s Reports (4 Coke 119b) that a condition in a lease that the lessee or his assigns shall not alien without the special license of the lessor, is determined by an alienation by licence, and no subsequent alienation is a breach of condition, nor does it give a right of entry to the lessor. The same case more properly titled Dumpor v Symms (Coke) or Dumper v Syms is reported by Sir George Croke (Croke\u27s Eliz. 815) The head note there reads: On a proviso that a lessee and his assigns shall not alien without licence, if the lessor give licence, the condition is entirely destroyed and the assignee may afterwards assign or demise the whole or any part of the term without licence; but otherwise a devise of the term would have been a breach of the condition

Evidence: Contradiction of Collateral Matter

It has been said so many times that a party is concluded by the answers of a witness on any collateral matter, that the real rule and the reasons therefor are very generally misunderstood and frequently misapplied. Some cases and some textbooks draw a very clear distinction between impeachment as applied to a collateral matter and contradiction as applied to a collateral matter. The distinguishing feature seems to be found in whether or not the answer sought to be refuted is elicited on direct examination or cross-examination. If an answer given on direct examination is to be disproven it is called contradiction. If an answer elicited on cross-examination is to be disproven it is called impeachment. It is obvious, of course, that this is all a matter of definition and despite a confusion of terms the question of refuting answers elicited either on direct or cross-examination is really a matter of impeachment and by the better writers is generally called impeachment by contradiction. Definitions are not particularly material to our present inquiry as we are here chiefly interested in applying this rule of evidence to collateral matters

Poliomyelitis in Malta, 1950-1951: An Epidemiological and Clinical Study of the Disease as it Affected the Armed Services

The basis of the treatment of the acute stage of poliomyelitis is presented and the meaning of muscle spasm is discussed. The results of treatment are shown and roughly compared with those of other epidemics

Alien Registration- Macfarlane, Robert G. (Mars Hill, Aroostook County)

https://digitalmaine.com/alien_docs/33984/thumbnail.jp

Photo- and solvatochromic properties of nitrobenzospiropyran in ionic liquids containing the [NTf2]- anion

The photo-, thermo- and solvatochromic properties of 2,3-dihydro-10,30,30-trimethyl-6-nitrospiro- [1-benzopyran-2,20-1H-indole] (BSP-NO2) were studied in ILs containing the anion [NTf2]- by UV-Vis absorption spectroscopy, ab initio molecular orbital theory and density functional theory (DFT) calculations. It was found that the kinetics and thermodynamics of the BSP-NO2 MC (merocyanine) equilibrium was sensitive to the nature of the cation. It was also observed that the imidazolium cation can form a through-space orbital interaction with the MC isomer, rather than a simple electrostatic interaction, thus preventing the MC conversion back to the BSP-NO2 isomer. The BSP-NO2 MC equilibrium thus serves as a model system for studying modes of interaction of the cations in ionic liquids

A study on the short-term cognitive outcome of percutaneous transluminal coronary angioplasty with intra-coronary stenting

Includes bibliographical references (leaves 23-26).This study explores the short term cognitive outcome of percutaneous transluminalcoronary angioplasty with intra-coronary stenting. Participants were assessed cognitively using specific neuropsychological tests used to measure performance in the seven cognitive domains. Forty people took part in the study, with twenty of them making up the stented group, and twenty of them making up the control group. The stented group were assessed a few days before, and then a few weeks after their procedures. The control group were simply assessed whenever they agreed to participate, and then again a few weeks later. There were ten males and ten females in each group. The participants were all between the ages of 34 and 75, and the sample had an average age of 57. The researchers were given access to patients at Groote Schuur Hospital and Gatesville Medical Centre. Analysis of variance was used in order to assess differences between the groups with respect to changes in cognitive performance in all seven cognitive domains. Results indicated that there were not significant differences between the groups, with respect to changes in cognitive performance between the first and second interviews

Contribution of growth hormone-releasing hormone and somatostatin to decreased growth hormone secretion in elderly men

Objective. The pathophysiology of the decline in circulating growth hormone (GH) concentrations that may occur with ageing remains elusive. We have investigated the potential contributions of decreased endogenous GH-releasing hormone (GHRH) and increased somatostatin secretion to this phenomenon.Design and methods. The strategy used was to stimulate GH secretion in 8 young (20 - 24 years old, body mass index (BMI) 22.8 ± 2.8 kg/m2) and 8 elderly (68- 82 years old, BMI 23.4 ± 1.6 kg/m2) male subjects on separate occasions by means of: (i) intravenous bolus 0.5 ).lg/kg D-Ala2 GHRH(1-29)-NH alone; (ii) 0.5 μg/kg GHRH after pretreatment with two oral doses of 50 mg atenolol (to inhibit somatostatin secretion); (iii) 1.25 mg oral bromocriptine alone (to increase endogenous GHRH and/or inhibit somatostatin); (iv) 50 mg oral atenolol plus 1.25 mg oral bromocriptine; and (v) 0.5 μg/kg GHRH after pre-treatment with 1.25 mg oral bromocriptine.Results. The elderly men had a significantly lower peak and area under curve (AUC) GH response to intravenous GHRH when compared with 8 young men (peak 3.1 ± 1.0 ng/ml v. 21.6 ± 5.0 ng/ ml, AUC 205 ±56 ng/ ml/min v.1 315 ± 295 ng/ ml/ min, P < 0.05). Pre-treatment with atenolol before GHRH administration produced no significant increase in peak and AUC GH response in both groups, whlch remained lower in the elderly men than in their young counterparts (peak 5.5 ±1.8 ng/ ml v. 29.3 ± 7.0 ng/ml, AUC 327 ± 90 ng/ml/min v. 2 017 ± 590 ng/ ml/min, P < 0.05). Bromocriptine alone did not cause a significant rise in GH concentration in either elderly or young subjects (peak 3.1 ± 1.1 v. 8.8 ± 3.2 ng/ ml, P > 0.05). When atenolol was administered before bromocriptine, both groups responded but the elderly subjects had a significantly greater peak and AUC response (peak 3.6 ± 0.7 v. 10:7 ± 2.1 ng/ ml; AUC 191 ± 39 v. 533 ± 125 ng/ ml/ min, P < 0.05). Bromocriptine given before GHRH failed to potentiate GHRH action on GH release in either group. Of 5 elderly men who tmderwent further evaluation of GH secretory ability, 2 subjects had GH levels > 10 ng/ rnl, either basally or after intravenous GHRH. The remaining 3 had an initially impaired GH response to bolus intravenous GHRH. After 100 μg GHRH subcutaneously twice daily for up to 2 weeks the GH responses to intravenous bolus GHRH (0.5μg /kg) were reassessed. One exhibited a normal response (> 10 ng/ rnl) after 1 week of daily GHRH treatment, another had a nearnormal response after 2 weeks (9.7 ng/ rnl), while the third still had an impaired response by the end of the 2-week treatment period (3.2 ng/ ml).Conclusions. The restoration of endogenous GH secretion in these elderly subjects by means of GHRH priming, and the failure of manipulation of somatostatinergic tone to restore a normal GH response to GHRH suggests that somatotroph atrophy due to a reduction in endogenous GHRH secretion is the principal cause of the diminished GH secretion with ageing