60 research outputs found
Atividade fĂsica, qualidade de vida e depressĂŁo durante a gravidez
This study examines physical activity patterns among women, from pre-pregnancy to the second trimester of pregnancy, and the relationship between physical activity status based on physical activity guidelines and health-related quality of life (HRQoL) and depression over pregnancy. 56 healthy pregnant women self reported physical activity, HRQoL and depression at 10-15 and 19-24 weeks of pregnancy and physical activity before pregnancy. Whereas vigorous leisure physical activity decreased after conception, moderate leisure physical activity and work related physical activity remained stable over time. The prevalence of recommended physical activity was 39.3% and 12.5% in the 1st and 2nd trimesters of pregnancy respectively, and 14.3% pre-pregnancy. From the 1st to the 2nd pregnancy trimester, most
physical HRQoL dimensions scores decreased and only mental component increased, independently
of physical activity status. No changes in mean depression scores were observed. These data suggest
that physical activity patterns change with pregnancy and that physical and mental components
are differentially affected by pregnancy course, independently of physical activity status.Este estudo examina os padrĂľes de atividade fĂsica antes
da concepção atÊ o segundo trimestre de gravidez
e a relação entre o nĂvel de atividade fĂsica, com base
nas recomendaçþes de atividade fĂsica, a qualidade de
vida relacionada Ă saĂşde (QVRS) e depressĂŁo ao longo
da gravidez. Cinquenta e seis grĂĄvidas saudĂĄveis reportaram
nĂvel de atividade fĂsica, QVRS e depressĂŁo
Ă s 10-15 e 19-24 semanas de gravidez, alĂŠm de atividade
fĂsica antes da concepção. Enquanto a atividade
fĂsica vigorosa no lazer diminuiu depois da concepção,
as atividades fĂsicas moderadas no lazer e no trabalho
mantiveram-se estĂĄveis. A prevalĂŞncia de atividade fĂ-
sica recomendada foi de 39,3%, 12,5% e 14,3% antes,
no primeiro e no segundo trimestres de gravidez, respectivamente.
Independentemente do estatuto de atividade
fĂsica, a maior parte dos escores nas dimensĂľes
fĂsicas da QVRS diminui do primeiro para o segundo
trimestre de gestação, e apenas o componente mental
aumenta. Não se verificaram alteraçþes nos escores
mĂŠdios de depressĂŁo. Estes dados sugerem que, com a
gravidez, hĂĄ alteração nos padrĂľes de atividade fĂsica;
alĂŠm disso, os componentes fĂsico e mental sĂŁo diferentemente
afetados pelo curso da gestação, independentemente
do nĂvel de atividade fĂsica
Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial
BACKGROUND: The development of vaccines to control the COVID-19 pandemic progression is a worldwide priority. CoronaVacÂŽ is an inactivated SARS-CoV-2 vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials in China, Brazil, Indonesia, Turkey, and Chile. METHODS: This study is a randomized, multicenter, and controlled phase 3 trial in healthy Chilean adults aged âĽ18 years. Volunteers received two doses of CoronaVacÂŽ separated by two (0-14 schedule) or four weeks (0-28 schedule). 2,302 volunteers were enrolled, 440 were part of the immunogenicity arm, and blood samples were obtained at different times. Samples from a single center are reported. Humoral immune responses were evaluated by measuring the neutralizing capacities of circulating antibodies. Cellular immune responses were assessed by ELISPOT and flow cytometry. Correlation matrixes were performed to evaluate correlations in the data measured. RESULTS: Both schedules exhibited robust neutralizing capacities with the response induced by the 0-28 schedule being better. No differences were found in the concentration of antibodies against the virus and different variants of concern between schedules. Stimulation of PBMCs with MPs induced the secretion of IFN-g and the expression of activation induced markers for both schedules. Correlation matrixes showed strong correlations between neutralizing antibodies and IFN-g secretion. CONCLUSIONS: Immunization with CoronaVacÂŽ in Chilean adults promotes robust cellular and humoral immune responses. The 0-28 schedule induced a stronger humoral immune response than the 0-14 schedule. FUNDING: Ministry of Health, Government of Chile, Confederation of Production and Commerce & Millennium Institute on Immunology and Immunotherapy, Chile. CLINICAL TRIAL NUMBER: NCT04651790
Parentsâ marital status and child physical abuse potential: the mediation of depression symptoms
Informed by a social interactional framework of stress and parenting, the aim of this study was to examine the mediating effect of depression symptoms on the asso- ciation between parentsâ marital status (married and divorced parents) and child physical abuse potential, in a Portuguese community sample. It was hypothesized that the possible observed differences between divorced and married parents in the child physical abuse potential would be explained by their depression symptoms. Parents (N = 892) were assessed in their marital status, severity of depression symptoms and child physical abuse potential. Results showed that, when compared with married parents, divorced parents had higher child physical abuse potential. However, parentsâ depression symptomatology was found as a mediator of the effect of marital status differences on child physical abuse potential. The influence of the status of divorced parents on the increase of child physical abuse potential was explained by the increase of the parentsâ depression symptoms. This finding suggested that parentsâ divorced status had no longer an effect on child physical abuse potential when parentsâ depression symptomatology was tested as a mediator vari- able. The present mediation model explained 47 % of the variability in the child physical abuse potential score. Prac- tical implications of these findings for prevention and psy- chological intervention are also discussed.info:eu-repo/semantics/publishedVersio
Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells
Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4â+âFoxp3+ regulatory T-cells (Tregs) reflected by lower CD25 surface density.Octapharma research funding; Fundação para a CiĂŞncia e a Tecnologia postdoctoral fellowships: (SFRH/BPD/20806/2004, SFRH/BPD/34648/2007); FCT Programa Pessoa travel grant
Uncovering Ecosystem Service Bundles through Social Preferences
Ecosystem service assessments have increasingly been used to support environmental management policies, mainly based on biophysical and economic indicators. However, few studies have coped with the social-cultural dimension of ecosystem services, despite being considered a research priority. We examined how ecosystem service bundles and trade-offs emerge from diverging social preferences toward ecosystem services delivered by various types of ecosystems in Spain. We conducted 3,379 direct face-to-face questionnaires in eight different case study sites from 2007 to 2011. Overall, 90.5% of the sampled population recognized the ecosystemâs capacity to deliver services. Formal studies, environmental behavior, and gender variables influenced the probability of people recognizing the ecosystemâs capacity to provide services. The ecosystem services most frequently perceived by people were regulating services; of those, air purification held the greatest importance. However, statistical analysis showed that socio-cultural factors and the conservation management strategy of ecosystems (i.e., National Park, Natural Park, or a non-protected area) have an effect on social preferences toward ecosystem services. Ecosystem service trade-offs and bundles were identified by analyzing social preferences through multivariate analysis (redundancy analysis and hierarchical cluster analysis). We found a clear trade-off among provisioning services (and recreational hunting) versus regulating services and almost all cultural services. We identified three ecosystem service bundles associated with the conservation management strategy and the rural-urban gradient. We conclude that socio-cultural preferences toward ecosystem services can serve as a tool to identify relevant services for people, the factors underlying these social preferences, and emerging ecosystem service bundles and trade-offs
Emancipatory practices of nurses in primary health care: the home visit as an instrument of health needs assessment
Objective Identify nursesâ emancipatory practices in primary care, to contribute to the improvement of health care. Method A case study type social research of qualitative nature, in which nurses of a primary health care service unit in SĂŁo Paulo were interviewed. Results The home visit was identified as a nursing practice possible to be expanded in order to identify social determinants of health, triggering emancipatory practices in the service. This expansion occurred because the design of health care labour intended by the service team changed its focus from the traditional object of health services, the disease. Conclusion First, it is advocated that social policies lead projects with the purpose of improving health needs. On the other hand, the daily labour needs to provide opportunities for reflection and discussion of healthcare projects, leading workers to propose labour-processes targeted to both the social determinants of health and peopleâs illness
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