1,272 research outputs found
Mr. and Mrs. Louis Thuis, Jr. to Jim (28 September 1962)
https://egrove.olemiss.edu/mercorr_pro/1263/thumbnail.jp
Physicochemical Characteristics Of The Effluents Of The University Private Clinics Of Kinshasa Treated In Upflow Anaerobic Sludge Blanket (UASB)
The uses of water at the hospital are very varied: ¶use food, medical, technical and therapeutic;¶and thus various types of effluents generate. ¶To have a first approach on the current situation of the rejection of the effluents of the CUK, it is necessary to identify the origin of the rejections and to then know the risks which they can generate. ¶The chemical substances used in the hospitals for the activities of care and medical research are generally found in the liquid effluents. ¶This research has like objective to characterize the physicochemical pollution of the effluents of the university private clinics of Kinshasa, to appreciate the intensity of this pollution in order to estimate its impacts on those, in order to carry out a pilot treatment by engine UASB. ¶System UASB pilot set up gave satisfactory results. ¶All the physicochemical parameters of the effluents underwent an improvement in occurrence the DCO which passed from 6250 mg/l to 20 mg/l and the DBO5 of 200 mg/l with 0 mg/l on figure 8. ¶That goes in the same way with the pH, turbidity, dissolved oxygen, them MY, the Nitrate, as well as conductivity. This system in addition to the lowering of organic and mineral pollution, allows the production of the biogas, which in great scale can be used for the power supply of the generating establishment of the effluents.¶
Type IIA orientifold compactification on SU(2)-structure manifolds
We investigate the effective theory of type IIA string theory on
six-dimensional orientifold backgrounds with SU(2)-structure. We focus on the
case of orientifolds with O6-planes, for which we compute the bosonic effective
action in the supergravity approximation. For a generic SU(2)-structure
background, we find that the low-energy effective theory is a gauged N=2
supergravity where moduli in both vector and hypermultiplets are charged. Since
all these supergravities descend from a corresponding N=4 background, their
scalar target space is always a quotient of a SU(1,1)/U(1) x
SO(6,n)/SO(6)xSO(n) coset, and is therefore also very constrained.Comment: 31 pages; v2: local report number adde
Broken rotational symmetry in the pseudogap phase of a high-Tc superconductor
The nature of the pseudogap phase is a central problem in the quest to
understand high-Tc cuprate superconductors. A fundamental question is what
symmetries are broken when that phase sets in below a temperature T*. There is
evidence from both polarized neutron diffraction and polar Kerr effect
measurements that time- reversal symmetry is broken, but at temperatures that
differ significantly. Broken rotational symmetry was detected by both
resistivity and inelastic neutron scattering at low doping and by scanning
tunnelling spectroscopy at low temperature, but with no clear connection to T*.
Here we report the observation of a large in-plane anisotropy of the Nernst
effect in YBa2Cu3Oy that sets in precisely at T*, throughout the doping phase
diagram. We show that the CuO chains of the orthorhombic lattice are not
responsible for this anisotropy, which is therefore an intrinsic property of
the CuO2 planes. We conclude that the pseudogap phase is an electronic state
which strongly breaks four-fold rotational symmetry. This narrows the range of
possible states considerably, pointing to stripe or nematic orders.Comment: Published version. Journal reference and DOI adde
Sialylation of campylobacter jejuni lipo-oligosaccharides: impact on phagocytosis and cytokine production in mice
<p>Background:
Guillain-Barré syndrome (GBS) is a post-infectious polyradiculoneuropathy, frequently associated with antecedent Campylobacter jejuni (C. jejuni) infection. The presence of sialic acid on C. jejuni lipo-oligosaccharide (LOS) is considered a risk factor for development of GBS as it crucially determines the structural homology between LOS and gangliosides, explaining the induction of cross-reactive neurotoxic antibodies. Sialylated C. jejuni are recognised by TLR4 and sialoadhesin; however, the functional implications of these interactions in vivo are unknown.</p>
<p>Methodology/Principal Findings:
In this study we investigated the effects of bacterial sialylation on phagocytosis and cytokine secretion by mouse myeloid cells in vitro and in vivo. Using fluorescently labelled GM1a/GD1a ganglioside-mimicking C. jejuni strains and corresponding (Cst-II-mutant) control strains lacking sialic acid, we show that sialylated C. jejuni was more efficiently phagocytosed in vitro by BM-MΦ, but not by BM-DC. In addition, LOS sialylation increased the production of IL-10, IL-6 and IFN-β by both BM-MΦ and BM-DC. Subsequent in vivo experiments revealed that sialylation augmented the deposition of fluorescent bacteria in splenic DC, but not macrophages. In addition, sialylation significantly amplified the production of type I interferons, which was independent of pDC.</p>
<p>Conclusions/Significance:
These results identify novel immune stimulatory effects of C. jejuni sialylation, which may be important in inducing cross-reactive humoral responses that cause GBS</p>
Moduli Stabilization and Cosmology of Type IIB on SU(2)-Structure Orientifolds
We consider type IIB flux compactifications on six-dimensional
SU(2)-structure manifolds with O5- and O7-planes. These six-dimensional spaces
allow not only for F_3 and H_3 fluxes but also for F_1 and F_5 fluxes. We
derive the four-dimensional N=1 scalar potential for such compactifications and
present one explicit example of a fully stabilized AdS vacuum with large volume
and small string coupling. We then discuss cosmological aspects of these
compactifications and derive several no-go theorems that forbid dS vacua and
slow-roll inflation under certain conditions. We also study concrete examples
of cosets and twisted tori and find that our no-go theorems forbid dS vacua and
slow-roll inflation in all but one of them. For the latter we find a dS
critical point with \epsilon numerically zero. However, the point has two
tachyons and eta-parameter \eta \approx -3.1.Comment: 35 pages + appendices, LaTeX2e; v2: numerical dS extremum added,
typos corrected, references adde
The effective action of D6-branes in N=1 type IIA orientifolds
We use a Kaluza-Klein reduction to compute the low-energy effective action
for the massless modes of a spacetime-filling D6-brane wrapped on a special
Lagrangian 3-cycle of a type IIA Calabi-Yau orientifold. The modifications to
the characteristic data of the N=1 bulk orientifold theory in the presence of a
D6-brane are analysed by studying the underlying Type IIA supergravity coupled
to the brane worldvolume in the democratic formulation and performing a
detailed dualisation procedure. The N=1 chiral coordinates are found to be in
agreement with expectations from mirror symmetry. We work out the Kahler
potential for the chiral superfields as well as the gauge kinetic functions for
the bulk and the brane gauge multiplets including the kinetic mixing between
the two. The scalar potential resulting from the dualisation procedure can be
formally interpreted in terms of a superpotential. Finally, the gauging of the
Peccei-Quinn shift symmetries of the complex structure multiplets reproduces
the D-term potential enforcing the calibration condition for special Lagrangian
3-cycles.Comment: 48 pages, v2: typos corrected, references adde
F-Theory and the Mordell-Weil Group of Elliptically-Fibered Calabi-Yau Threefolds
The Mordell-Weil group of an elliptically fibered Calabi-Yau threefold X
contains information about the abelian sector of the six-dimensional theory
obtained by compactifying F-theory on X. After examining features of the
abelian anomaly coefficient matrix and U(1) charge quantization conditions of
general F-theory vacua, we study Calabi-Yau threefolds with Mordell-Weil
rank-one as a first step towards understanding the features of the Mordell-Weil
group of threefolds in more detail. In particular, we generate an interesting
class of F-theory models with U(1) gauge symmetry that have matter with both
charges 1 and 2. The anomaly equations --- which relate the Neron-Tate height
of a section to intersection numbers between the section and fibral rational
curves of the manifold --- serve as an important tool in our analysis.Comment: 29 pages + appendices, 5 figures; v2: minor correction
Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extrachromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.This work was supported by the Tumorzentrum Heidelberg/Mannheim grant (D.10026941)and by March of Dimes Research Foundation grant #1-FY06-377 and NIH R01 GM069514
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