Mother–infant interaction in schizophrenia:Transmitting risk or resilience? A systematic review of the literature

Purpose: The parent–infant relationship is an important context for identifying very early risk and resilience factors and targets for the development of preventative interventions. The aim of this study was to systematically review studies investigating the early caregiver–infant relationship and attachment in offspring of parents with schizophrenia. Methods: We searched computerized databases for relevant articles investigating the relationship between early caregiver–infant relationship and outcomes for offspring of a caregiver with a diagnosis of schizophrenia. Studies were assessed for risk of bias. Results: We identified 27 studies derived from 10 cohorts, comprising 208 women diagnosed with schizophrenia, 71 with other psychoses, 203 women with depression, 59 women with mania/bipolar disorder, 40 with personality disorder, 8 with unspecified mental disorders and 119 non-psychiatric controls. There was some evidence to support disturbances in maternal behaviour amongst those with a diagnosis of schizophrenia and there was more limited evidence of disturbances in infant behaviour and mutuality of interaction. Conclusions: Further research should investigate both sources of resilience and risk in the development of offspring of parents with a diagnosis of schizophrenia and psychosis. Given the lack of specificity observed in this review, these studies should also include maternal affective disorders including depressive and bipolar disorders

Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa

Although there is well-documented evidence for hyperactivity of hypothalamic–pituitary–adrenal (HPA) axis function in anorexia nervosa (AN), there has been little research into secretory patterns of salivary cortisol and dehydroepiandrosterone (DHEA) in this condition. The cortisol awakening response (CAR), a prominent and discrete feature of the cortisol cycle, has not been extensively explored in adolescent AN. Saliva samples were collected at awakening, 30 min and 12 h post-awakening on two consecutive weekdays from eight female adolescents with clinically diagnosed AN and 41 healthy control (HC) age-matched females. Adolescent AN patients had greater salivary cortisol and DHEA concentrations than HC girls at all points. Increased hormone secretion was unrelated to body mass index. However, despite hypersecretion of both hormones, the circadian pattern including the CAR paralleled that of the HC group. Findings from this preliminary study confirm dysregulation of HPA axis function in adolescent AN as evidenced by hypersecretion of both cortisol and DHEA, which share the common secretagogue adrenocorticotropic hormone. However, the parallel diurnal profiles for AN and HC participants, including the CAR, may indicate hypersecretion per se rather than differential regulation of the diurnal pattern of these two adrenal steroids in AN

Relational security moderates the effect of serotonin transporter gene polymorphism (5-HTTLPR) on stress generation and depression among adolescents

Previous research demonstrates that carriers of the short allele of the serotonin transporter gene (5-HTTLPR) show both greater susceptibility to depression in response to stressful life events and higher rates of generation of stressful events in response to depression. The current study examines relational security (i.e., self-reported beliefs about attachment security) as a moderator of these effects, building on emerging research suggesting that the short allele acts as a marker of sensitivity to the social environment. Participants were 354 Caucasian adolescents oversampled for maternal depression (137 male, 217 female), assessed at ages 15 and 20. Results indicated that the short allele predicted increased stress generation at age 20 among those with low age 15 security but decreased stress generation among those with high security, and revealed a three-way interaction between age 15 depression, age 15 security, and genotype, where depression predicted stress generation only among short allele carriers with low security. Further, among boys only, security interacted with genotype to predict longitudinal changes in depression diagnosis, with the s-allele predicting relative increases in probability of depression among boys with low security but decreases among boys with high security. Results support the notion of the short allele as a marker of social reactivity, and suggest that attachment security may buffer against the genetic vulnerability introduced by the short allele, in line with predictions of the differential susceptibility theory

Enhancing Maternal Sensitivity and Emotional Wellbeing Through a Preventative Parent–Child Relationship Intervention in a Community Setting

The aim of this applied study was to explore the outcomes of a parent–child relationship intervention for enhancing maternal sensitivity to the infant’s needs and increasing maternal emotional wellbeing in the parenting situation. Whilst there is extensive support established for interventions with high-risk and at-risk populations, there is limited evidence from programs that target low risk parents who on presentation are often identified to have symptoms of depression, anxiety, or stress. A mixed methods research design was utilised to present quantitative and qualitative outcomes at pre- and post-intervention from 14 participants in the Tuned In Parenting program at a community health organisation. Self-report measures were summarised to provide a descriptive profile of participants. Recorded mother–child semi-structured play interactions were analysed using a behaviour rating scale. Transcripts of audio recordings from semi-structured interviews were analysed using a thematic and content approach. Participants demonstrated enhanced maternal sensitive responsiveness and a reduction in symptoms of maternal depression following program completion. The preventative relationship based intervention holds considerable promise in improving maternal wellbeing and transforming relationships between mothers and their children

The Mother-Infant Sleep Nexus: Night-Time Experiences in Early Infancy and Later Outcomes

Following their infant’s birth, parents in many societies in the global North experience acute sleep disruption for which few are adequately prepared, and which may result in profound and enduring negative outcomes such as parental depression and anxiety. For some babies, their parent’s inability to cope with sleep disruption results in harmful short-term outcomes (such as infants being medicalised, medicated, and abused); long-term consequences are more difficult to identify and therefore are understudied. Yet other parents, and indeed whole nations of parents, seem resilient to infant-related sleep disruption and take it all in their stride—so what differs? This chapter considers parental perceptions and experiences of night-time infant care and the strategies that are promoted and used for coping with infant-related sleep disruption. The potential consequences of these for parents, their babies, and society in general will be explored with suggestions for future research to fill current evidence gaps