On computations of angular momentum and its flux in numerical relativity

The purpose of this note is to point out ambiguities that appear in the calculation of angular momentum and its radiated counterpart when some simple formulae are used to compute them. We illustrate, in two simple different examples, how incorrect results can be obtained with them. Additionally, we discuss the magnitude of possible errors in well known situations.Comment: 8 pages. Minor improvements . To appear in Class. Quantum Gra

The Goldberg-Sachs theorem in linearized gravity

The Goldberg-Sachs theorem has been very useful in constructing algebraically special exact solutions of Einstein vacuum equation. Most of the physical meaningful vacuum exact solutions are algebraically special. We show that the Goldberg-Sachs theorem is not true in linearized gravity. This is a remarkable result, which gives light on the understanding of the physical meaning of the linearized solutions.Comment: 6 pages, no figures, LaTeX 2

Intrinsic angular momentum for radiating spacetimes which agrees with the Komar integral in the axisymmetric case

Here, we present a new definition of intrinsic angular momentum at future null infinity, based on the charge-integral approach. This definition is suitable for the general case of radiating spacetimes without symmetries, which does not suffer from supertranslation ambiguities. In the case of axial symmetry, this new definition agrees with the Komar integral.publishedVersionFil: Gallo, Emanuel. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Gallo, Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina.Fil: Moreschi, Osvaldo Mario. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Moreschi, Osvaldo Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina.Física de Partículas y Campo

On a class of 2-surface observables in general relativity

The boundary conditions for canonical vacuum general relativity is investigated at the quasi-local level. It is shown that fixing the area element on the 2- surface S (rather than the induced 2-metric) is enough to have a well defined constraint algebra, and a well defined Poisson algebra of basic Hamiltonians parameterized by shifts that are tangent to and divergence-free on $. The evolution equations preserve these boundary conditions and the value of the basic Hamiltonian gives 2+2 covariant, gauge-invariant 2-surface observables. The meaning of these observables is also discussed.Comment: 11 pages, a discussion of the observables in stationary spacetimes is included, new references are added, typos correcte

The AdS/CFT Correspondence and a New Positive Energy Conjecture for General Relativity

We examine the AdS/CFT correspondence when the gauge theory is considered on a compactified space with supersymmetry breaking boundary conditions. We find that the corresponding supergravity solution has a negative energy, in agreement with the expected negative Casimir energy in the field theory. Stability of the gauge theory would imply that this supergravity solution has minimum energy among all solutions with the same boundary conditions. Hence we are lead to conjecture a new positive energy theorem for asymptotically locally Anti-de Sitter spacetimes. We show that the candidate minimum energy solution is stable against all quadratic fluctuations of the metric.Comment: 25 pages, harvma

Bioethical and medico-legal implications of withdrawing artificial nutrition and hydration from adults in critical care

The withdrawal of artificial nutrition and hydration or other life-sustaining treatments is a clinical decision, made in ICUs or in other settings, involving patients suffering from serious and irreversible diseases or impaired consciousness. Such clinical decisions must be made in the best interests of the patient, and must respect the wishes previously expressed by patients, laid down in their wills, in advance directives or in information passed on by relatives or legally appointed health-care agents, and in observance of common bioethical and legal rules in individual nations. Intensivists who are expert in the management of lifesustaining treatments are also involved in deciding when to withdraw futile therapies and instigate end-of-life care procedures for dying patients, with the sole aim of providing comfort and ensuring that suffering is not prolonged unnecessaril

Glutamine dipeptide supplementation improves clinical responses in patients with diabetic foot syndrome

ABSTRACT The effect of glutamine dipeptide (GDP) supplementation in patients with diabetic foot syndrome was evaluated. A total of 22 patients took part in the study. GDP was supplied in 10 g sachets, and was dissolved in water immediately before use, with ingestion once a day, after lunch or after dinner (20 g/day) over a period of 30 days. Quantification of foot insensitive areas, oxidative stress, blood cytokines, and biochemical, hematological and toxicological parameters was performed before and after GDP supplementation. We observed an increase in blood levels of interferon-&#945; (P=0.023), interferon-&#947; (P=0.038), interleukin-4 (P=0.003), interleukin-6 (P=0.0025), interleukin-7 (P=0.028), interleukin-12 p40 (P=0.017), interleukin-13 (P=0.001), leukocytes (P=0.037), eosinophils (P=0.049), and typical lymphocytes (P<0.001) due to GDP administration. In addition, we observed a reduced number (P=0.048) of insensitive areas on the foot, and reduction (P=0.047) of fasting hyperglycemia. Patients also showed increased blood high density lipoprotein (P<0.01) and protein thiol groups (P=0.004). These favorable results were associated with the absence of renal and hepatic toxicity. These results are of clinical relevance, since supplementation with GDP over 30 days improved clinical responses in patients with diabetic foot syndrome

Cellular Basis of Tissue Regeneration by Omentum

The omentum is a sheet-like tissue attached to the greater curvature of the stomach and contains secondary lymphoid organs called milky spots. The omentum has been used for its healing potential for over 100 years by transposing the omental pedicle to injured organs (omental transposition), but the mechanism by which omentum helps the healing process of damaged tissues is not well understood. Omental transposition promotes expansion of pancreatic islets, hepatocytes, embryonic kidney, and neurons. Omental cells (OCs) can be activated by foreign bodies in vivo. Once activated, they become a rich source for growth factors and express pluripotent stem cell markers. Moreover, OCs become engrafted in injured tissues suggesting that they might function as stem cells

Development of selective agonists and antagonists of P2Y receptors

Although elucidation of the medicinal chemistry of agonists and antagonists of the P2Y receptors has lagged behind that of many other members of group A G protein-coupled receptors, detailed qualitative and quantitative structure–activity relationships (SARs) were recently constructed for several of the subtypes. Agonists selective for P2Y1, P2Y2, and P2Y6 receptors and nucleotide antagonists selective for P2Y1 and P2Y12 receptors are now known. Selective nonnucleotide antagonists were reported for P2Y1, P2Y2, P2Y6, P2Y11, P2Y12, and P2Y13 receptors. At the P2Y1 and P2Y12 receptors, nucleotide agonists (5′-diphosphate derivatives) were converted into antagonists of nanomolar affinity by altering the phosphate moieties, with a focus particularly on the ribose conformation and substitution pattern. Nucleotide analogues with conformationally constrained ribose-like rings were introduced as selective receptor probes for P2Y1 and P2Y6 receptors. Screening chemically diverse compound libraries has begun to yield new lead compounds for the development of P2Y receptor antagonists, such as competitive P2Y12 receptor antagonists with antithrombotic activity. Selective agonists for the P2Y4, P2Y11, and P2Y13 receptors and selective antagonists for P2Y4 and P2Y14 receptors have not yet been identified. The P2Y14 receptor appears to be the most restrictive of the class with respect to modification of the nucleobase, ribose, and phosphate moieties. The continuing process of ligand design for the P2Y receptors will aid in the identification of new clinical targets