Assessment of emphysematous change and pulmonary function after lobectomy for lung cancer - quantitative 3D-CT analysis

Background: Lung volume reduction surgery (LVRS) in patients with severe chronic pulmonary emphysema (CPE) results in postoperative improvement in pulmonary function. Lobectomy in patients with lung cancer also has the same effect.Methods: One hundred fourteen patients underwent lobectomy for lung cancer from 2006 to 2011. Computed tomography (CT) and pulmonary function test (PFT) were performed preoperatively and six months to one half year after surgery. All CT examinations were performed using a 64-row multidetector CT scanner during a breath-hold at deep inspiration. Total lung volume (TLV), each lobe volume, and low attenuation area (LAA) were extracted from CT data of each patient.Results: TLV after upper lobectomy was increased signifi cantly compared with lower lobectomy (111.0 ± 18.9% vs 103.9 ± 16.1%;p=0.05). There was no relationship between lung volume change and preoperative LAA%. In contrast, LAA% change demonstrated a negative relationship with preoperative LAA% (r=0.4590). In the group defi ned as preoperative LAA% more than 20%, postoperative LAA% decreased signifi cantly (34.9 ± 13.9% to 32.8 ± 18.4%; p<0.01) and FEV1% predicted improved (70. 3 ± 9.7% to 75.3 ± 12.7%;p=0.03).Conclusions: The resected lobe region is more important than the resected lobe volume (RLV) and segment number in TLV change after lobectomy. Preoperative LAA% is a negative factor of LAA% change. Therefore patients with severe emphysematous lung are less likely to increase their postoperative LAA%. Lobectomy for patients with high LAA% provides improved FEV1 % predicted.departmental bulletin pape

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

The androgen receptor (AR) is a ligand-dependent transcription factor that belongs to the family of nuclear receptors, and its activity is regulated by numerous AR coregulators. AR plays an important role in prostate development and cancer. In this study, we found that TRIM24/transcriptional intermediary factor 1α (TIF1α), which is known as a ligand-dependent nuclear receptor co-regulator, interacts with AR and enhances transcriptional activity of AR by dihydrotestosterone in prostate cancer cells. We showed that TRIM24 functionally interacts with TIP60, which acts as a coactivator of AR and synergizes with TIP60 in the transactivation of AR. We also showed that TRIM24 binds to bromodomain containing 7 (BRD7), which can negatively regulate cell proliferation and growth. A luciferase assay indicated that BRD7 represses the AR transactivation activity upregulated by TRIM24. These findings indicate that TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7

Reconnaissance report on the 2000 Kohzushima Kinkai earthquake

金沢大学理工研究域地球社会基盤学系An MJ6.4 earthquake occurred on July 1, 2000 offshore of Kohzushima Island in the Tokyo municipal jurisdiction. Large tremors also were felt on Kohzushima on July 9 and on Niijima on July 15. This is the damage investigation report on the 2000 Kohzushima Kinkai earthquake mad e by a JSCE reconnaissance team. Earthquake swarms continued near Kohzushima, Niijima, and Shikinejima islands for about three months. A JMA seismic intensity of lower 6 was recorded twice on Kohzushima during July, 2000. An outline of the earthquake and aftershocks and the damage done to civil structures is given. Slope failures, damage to retaining walls and disaster responses, in particular, are focused on

Reconnaissance report on the 2000 Kohzushima Kinkai earthquake

金沢大学理工研究域地球社会基盤学系An MJ6.4 earthquake occurred on July 1, 2000 offshore of Kohzushima Island in the Tokyo municipal jurisdiction. Large tremors also were felt on Kohzushima on July 9 and on Niijima on July 15. This is the damage investigation report on the 2000 Kohzushima Kinkai earthquake made by a JSCE reconnaissance team. Earthquake swarms continued near Kohzushima, Niijima, and Shikinejima islands for about three months. A JMA seismic intensity of lower 6 was recorded twice on Kohzushima during July, 2000. An outline of the earthquake and aftershocks and the damage done to civil structures is given. Slope failures, damage to retaining walls and disaster responses, in particular, are focused on

Total thoracoscopic lung segmentectomy of anterior basal segment of the right lower lobe (RS8) for NSCLC stage IA (case report)

Abstract A 69-year-old woman with a pulmonary nodule in anterior basal segment of the right lower lobe (RS8) was referred to our department. The diameter of the tumor was 12 mm, and it had increased over a few months. First, video-assisted thoracoscopic lung surgery (VATS) biopsy of the pulmonary nodule was carried out. Frozen section examination of this nodule confirmed the diagnosis of bronchioloalveolar carcinoma (BAC). Segmentectomy of RS8 with lower mediastinal node dissection (ND2a-1) was performed. The intersegmental plane was identified using the intersegmental veins as landmarks and the demarcation between the resected (inflated) and preserved (collapsed) lungs. Electrocautery at 70 watts was used to divide the intersegmental plane. A vessel sealing system was used to seal and cut the pulmonary arteries. Postoperative histopathological examination revealed that the tumor was T1aN0M0 BAC, and the minimal distance between the surgical margin and the tumor edge was 15 mm. The patient was discharged from hospital on postoperative day 5 without any complications.</p