Genomics and epidemiology for gastric adenocarcinomas (GE4GAC): a Brazilian initiative to study gastric cancer

Abstract Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Dilemas e desafios da Proteção Internacional dos Direitos Humanos no limiar do século XXI

Balanço dos avanços conceituais e práticos e das limitações ainda existentes, de ordem legal ou política, à proteção universal dos direitos humanos, ressaltando a construção progressiva dos instrumentos disponíveis - as convenções centrais - e o papel das conferências e das cortes regionais de defesa dos direitos humanos.<br>Review of the conceptual and practical progresses and the restrictions that still exists, of legal or political order, to the universal protection of human rights, emphasizing the progressive building of the available instruments - the central conventions and the role of the conferences and regional courts of human rights defense

Judicialização da política externa e direitos humanos

O objetivo do artigo é fornecer uma base teórica para a compreensão da "judicialização da política externa", tomando como ponto de partida as elaborações clássicas de Locke e Montesquieu que conferiam ao Executivo uma grande dose de discricionariedade na condução das relações exteriores, gradualmente contrabalançada pelo Legislativo e pelo Judiciário. Revisitando a literatura sobre "judicialização da política" e as deturpações a que foi submetida, o autor procura aplicar o conceito para a política externa e analisa cinco casos da Corte Interamericana de Direitos Humanos.<br>The purpose of the article is to provide a theoretical basis for the application of judicial proceedings (judicialização) in the foreign policy. The starting point is the classical conceptions of Locke and Montesquieu which conferred a great deal of discretion to the Executive for managing foreign relations, what was gradually counterbalanced by the Legislative and the Judiciary. Approaching the Brazilian literature on the expansion of judicial power to the politics and subsequent misrepresentations, the author tries to apply the concept to the foreign policy and analyses five cases of the Inter-American Court of Human Rights

Desafios globais contemporâneos: cenário de convergências no direito internacional Global contemporary challenges: convergences scenario in international law

O cenário internacional contemporâneo é caracterizado por uma multiplicidade de agentes e interesses, gerando uma complexa teia de relações econômicas, sociais e jurídicas. os desafios globais representados pelas inéditas relações exigem respostas rápidas e eficientes por parte do direito. Essa jornada em busca das soluções para os conflitos emergentes do plano internacional requer uma releitura do significado da divisão entre as esferas pública e privada do direito. Seja através do crescimento dos fundos soberanos de riqueza, que traz à luz uma série de novos paradigmas no campo econômico, sobretudo a convergência entre o papel do estado e o papel do investidor internacional; seja através do encontro entre a necessidade de proteção aos direitos humanos e a harmonização do sistema multilateral de comércio internacional; seja através das interseções entre a governança global e a tutela dos direitos difusos, o direito internacional certamente caminha para a convergência.<br>The contemporary international scenario is characterized by a multiplicity of actors and interests, creating a complex web of economic, social and legal relationships. The challenges represented by these new relationships need rapid and efficient responses by law. This journey seeking the solutions to the conflicts arising from the international arena requires a reassessment of the meaning of the division between public and private spheres of law. Through the growth of sovereign wealth funds, which arises several new paradigms in the economic field, noticeably the convergence between the role of the state and the role of the international investor; through the encounter between the necessity to protect human rights and harmonize the multilateral international trade system, or through the intersections between global governance and the protection of diffuse rights, international law is certainly moving towards the convergence