Augmenting mental models

The complexity of conceptualizing mental models has made Virtual Reality an interesting way to enhance communication and understanding between individuals working together on a project or idea. Here, the authors discuss practical applications of using VR for this purpose

Slowing heavy, ground-state molecules using an alternating gradient decelerator

Cold supersonic beams of molecules can be slowed down using a switched sequence of electrostatic field gradients. The energy to be removed is proportional to the mass of the molecules. Here we report deceleration of YbF, which is 7 times heavier than any molecule previously decelerated. We use an alternating gradient structure to decelerate and focus the molecules in their ground state. We show that the decelerator exhibits the axial and transverse stability required to bring these molecules to rest. Our work significantly extends the range of molecules amenable to this powerful method of cooling and trapping.Comment: 4 pages, 5 figure

Can Polymer Coils be modeled as "Soft Colloids"?

We map dilute or semi-dilute solutions of non-intersecting polymer chains onto a fluid of ``soft'' particles interacting via a concentration dependent effective pair potential, by inverting the pair distribution function of the centers of mass of the initial polymer chains. A similar inversion is used to derive an effective wall-polymer potential; these potentials are combined to successfully reproduce the calculated exact depletion interaction induced by non-intersecting polymers between two walls. The mapping opens up the possibility of large-scale simulations of polymer solutions in complex geometries.Comment: 4 pages, 3 figures ReVTeX[epsfig,multicol,amssymb] references update

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics

Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates a plethora of phosphorylation events. However, it has remained unclear whether thrombin signaling is exclusively mediated through PAR1. Furthermore, mechanistic insight into activation and inhibition of PAR1-mediated EC signaling is lacking. In addition, signaling networks of biased PAR1 activation after differential cleavage of the PAR1 N terminus have remained an unresolved issue. Here, we used a quantitative phosphoproteomics approach to show that classical and peptide activation of PAR1 induce highly similar signaling, that low thrombin concentrations initiate only limited phosphoregulation, and that the PAR1 inhibitors vorapaxar and parmodulin-2 demonstrate distinct antagonistic properties. Subsequent analysis of the thrombin-regulated phosphosites in the presence of PAR1 inhibitors revealed that biased activation of PAR1 is not solely linked to a specific G-protein downstream of PAR1. In addition, we showed that only the canonical thrombin PAR1 tethered ligand induces extensive early phosphoregulation in ECs. Our study provides detailed insight in the signaling mechanisms downstream of PAR1. Our data demonstrate that thrombin-induced EC phosphoregulation is mediated exclusively through PAR1, that thrombin and thrombin-tethered ligand peptide induce similar phosphoregulation, and that only canonical PAR1 cleavage by thrombin generates a tethered ligand that potently induces early signaling. Furthermore, platelet PAR1 inhibitors directly affect EC signaling, indicating that it will be a challenge to design a PAR1 antagonist that will target only those pathways responsible for tissue pathology

On the interplay between flaring and shadowing in disks around Herbig Ae/Be stars

Based on the SED, Herbig stars have been categorized into two observational groups, reflecting their overall disk structure: group I members have disks with a higher degree of flaring than their group II counterparts. We investigate the 5-35 um Spitzer IRS spectra of a sample of 13 group I sources and 20 group II sources. We focus on the continuum emission to study the underlying disk geometry. We have determined the [30/13.5] and [13.5/7] continuum flux ratios. The 7-um flux excess with respect to the stellar photosphere is measured, as a marker for the strength of the near-IR emission produced by the inner disk. We have compared our data to self-consistent passive-disk model spectra, for which the same quantities were derived. We confirm the literature result that the difference in continuum emission between group I and II sources can largely be explained by a different amount of small dust grains. However, we report a strong correlation between the [30/13.5] and [13.5/7] flux ratios for Meeus group II sources. Moreover, the [30/13.5] flux ratio decreases with increasing 7-um excess for all targets in the sample. To explain these correlations with the models, we need to introduce an artificial scaling factor for the inner disk height. In roughly 50% of the Herbig Ae/Be stars in our sample, the inner disk must be inflated by a factor 2 to 3 beyond what hydrostatic calculations predict. The total disk mass in small dust grains determines the degree of flaring. We conclude, however, that for any given disk mass in small dust grains, the shadowing of the outer (tens of AU) disk is determined by the scale height of the inner disk (1 AU). The inner disk partially obscures the outer disk, reducing the disk surface temperature. Here, for the first time, we prove these effects observationally.Comment: 4 pages, 3 figures, accepted by A&

Anisotropic and strong negative magneto-resistance in the three-dimensional topological insulator Bi2Se3

We report on high-field angle-dependent magneto-transport measurements on epitaxial thin films of Bi2Se3, a three-dimensional topological insulator. At low temperature, we observe quantum oscillations that demonstrate the simultaneous presence of bulk and surface carriers. The magneto- resistance of Bi2Se3 is found to be highly anisotropic. In the presence of a parallel electric and magnetic field, we observe a strong negative longitudinal magneto-resistance that has been consid- ered as a smoking-gun for the presence of chiral fermions in a certain class of semi-metals due to the so-called axial anomaly. Its observation in a three-dimensional topological insulator implies that the axial anomaly may be in fact a far more generic phenomenon than originally thought.Comment: 6 pages, 4 figure

Collisional and thermal ionization of sodium Rydberg atoms I. Experiment for nS and nD atoms with n=8-20

Collisional and thermal ionization of sodium nS and nD Rydberg atoms with n=8-20 has been studied. The experiments were performed using a two-step pulsed laser excitation in an effusive atomic beam at atom density of about 2 10^{10} cm^{-3}. Molecular and atomic ions from associative, Penning, and thermal ionization processes were detected. It has been found that the atomic ions were created mainly due to photoionization of Rydberg atoms by photons of blackbody radiation at the ambient temperature of 300K. Blackbody ionization rates and effective lifetimes of Rydberg states of interest were determined. The molecular ions were found to be from associative ionization in Na(nL)+Na(3S) collisions. Rate constants of associative ionization have been measured using an original method based on relative measurements of Na_{2}^{+} and Na^{+} ion signals.Comment: 23 pages, 10 figure

Sensory navigation device for blind people

[EN] This paper presents a new Electronic Travel Aid (ETA) 'Acoustic Prototype' which is especially suited to facilitate the navigation of visually impaired users. The device consists of a set of 3-Dimensional Complementary Metal Oxide Semiconductor (3-D CMOS) image sensors based on the three-dimensional integration and Complementary Metal-Oxide Semiconductor (CMOS) processing techniques implemented into a pair of glasses, stereo headphones as well as a Field-Programmable Gate Array (FPGA) used as processing unit. The device is intended to be used as a complementary device to navigation through both open known and unknown environments. The FPGA and the 3D-CMOS image sensor electronics control object detection. Distance measurement is achieved by using chip-integrated technology based on the Multiple Short Time Integration method. The processed information of the object distance is presented to the user via acoustic sounds through stereophonic headphones. The user interprets the information as an acoustic image of the surrounding environment. The Acoustic Prototype transforms the surface of the objects of the real environment into acoustical sounds. The method used is similar to a bat's acoustic orientation. Having good hearing ability, with few weeks training the users are able to perceive not only the presence of an object but also the object form (that is, if the object is round, if it has corners, if it is a car or a box, if it is a cardboard object or if it is an iron or cement object, a tree, a person, a static or moving object). The information is continuously delivered to the user in a few nanoseconds until the device is shut down, helping the end user to perceive the information in real time.The first author would like to acknowledge that this research was funded through the FP6 European project CASBLiP number 027063 and Project number 2062 of the Programa de Apoyo a la Investigacion y Desarrollo 2011 from the Universitat Politecnica de Valencia.Dunai, L.; Peris Fajarnes, G.; Lluna Gil, E.; Defez Garcia, B. (2013). Sensory navigation device for blind people. Journal of Navigation. 66(3):346-362. doi:10.1017/S0373463312000574S34636266