54/07/04 (4) Marilyn Sheppard Autopsy Report

Marilyn Sheppard autopsy report performed and written by Dr. Gerber in 195

54/07/04 (1) Autopsy Protocol of Marilyn Reese Sheppard

The 1954 autopsy protocol of Marilyn Sheppard was performed by Dr. Samuel Gerber. An autopsy protocol is a standardized checklist of steps in a basic forensic postmortem examination that is meant to be objective and determine the comprehensive condition the body, including cause of death. Dr. Gerber determined that The death of the decedent was the result of: multiple impacts to head and face with... fractures of skull and... contusions of brain

54/07/04 (4) Marilyn Sheppard Autopsy Report

Marilyn Sheppard autopsy report performed and written by Dr. Gerber in 195

58/07/25 Lab Examination Letter from Gerber to Story re: 1958 Materials Found

Letter to Cleveland Chief of Police Frank W. Story explaining the tests and lab results of found evidence (knit cotton material, rock, piece of wood) submitted for possible association with the murder of Marilyn Sheppard. Cuyahoga County Coroner Sam Gerber summarized his results at the end of a five-page document: An exhaustive study of this material failed to yield any evidence to warrant suspicion that it could have been associated with the murder of Marilyn Sheppard

Verdict from Coroner on death of Marilyn Reese Sheppard

The Corner\u27s Verdict contains the legal cause of death of Marilyn Sheppard. Dr. Gerber\u27s verdict stated that the cause of death was brain contusions, hemorrhages, and a fractured skull resulting from multiple impacts to the skull and face. Dr. Gerber also details the Coroner\u27s Inquest performed to determine the cause and manner of Marilyn Sheppard\u27s death. The coroner\u27s verdict names Dr. Sam Sheppard as the murderer

Verdict from Coroner on death of Marilyn Reese Sheppard

The Corner\u27s Verdict contains the legal cause of death of Marilyn Sheppard. Dr. Gerber\u27s verdict stated that the cause of death was brain contusions, hemorrhages, and a fractured skull resulting from multiple impacts to the skull and face. Dr. Gerber also details the Coroner\u27s Inquest performed to determine the cause and manner of Marilyn Sheppard\u27s death. The coroner\u27s verdict names Dr. Sam Sheppard as the murderer

Multiangle observations of Arctic clouds from FIRE ACE: June 3, 1998, case study

In May and June 1998 the Airborne Multiangle Imaging Spectroradiometer (AirMISR) participated in the FIRE Arctic Cloud Experiment (ACE). AirMISR is an airborne instrument for obtaining multiangle imagery similar to that of the satellite-borne MISR instrument. This paper presents a detailed analysis of the data collected on June 3, 1998. In particular, AirMISR radiance measurements are compared with measurements made by two other instruments, the Cloud Absorption Radiometer (CAR) and the MODIS airborne simulator (MAS), as well as to plane-parallel radiative transfer simulations. It is found that the AirMISR radiance measurements and albedo estimates compare favorably both with the other instruments and with the radiative transfer simulations. In addition to radiance and albedo, the multiangle AirMISR data can be used to obtain estimates of cloud top height using stereoimaging techniques. Comparison of AirMISR retrieved cloud top height (using the complete MISR-based stereoimaging approach) shows excellent agreement with the measurements from the airborne Cloud Lidar System (CLS) and ground-based millimeterwave cloud radar

Neutrophil-lymphocyte ratio as a predictor of outcome following traumatic brain injury: Systematic review and meta-analysis

Objetivos: El cociente neutrófilo-linfocito (NLR) es un parámetro hematológico sencillo y de realización rutinaria; sin embargo, los estudios sobre el NLR como herramienta pronóstica en el traumatismo craneoencefálico (TCE) han arrojado resultados contradictorios. Materiales y métodos: Esta revisión sistemática y meta-análisis se llevó a cabo de acuerdo con las Preferred Reporting Items in the Systematic Review and Meta-Analysis guidelines 2020. Se realizaron búsquedas en las bases de datos electrónicas de PubMed, Cochrane Library, Web of Science y Scopus. La población consistió en pacientes con TCE en ausencia de lesión extracraneal moderada y grave. Para el análisis se tomó el RNL del día 1. Los resultados evaluados fueron la mortalidad y la escala de resultados de Glasgow (GOS). No se impusieron restricciones en cuanto al idioma, el año y el país de publicación, y la duración del seguimiento. Se excluyeron del estudio los estudios con animales. Los estudios en los que se comunicaron datos inadecuados para los resultados se incluyeron en la síntesis cualitativa, pero se excluyeron de la síntesis cuantitativa. La calidad de los estudios se evaluó mediante la escala Newcastle-Ottawa (NOS). El riesgo de sesgo se estimó mediante la herramienta de riesgo de sesgo Cochrane RoBANS. Resultados: Se recuperaron 7213 citas mediante la estrategia de búsqueda y se excluyeron 2097 citas en función del cribado del título y el resumen. Se recuperó el texto completo de 40 artículos y se sometió a los criterios de elegibilidad, de los cuales 28 fueron excluidos del estudio. Doce estudios fueron elegibles para la síntesis de la revisión sistemática, mientras que siete estudios cumplieron los requisitos para el metanálisis. La puntuación media de los artículos fue de 8/9 según NOS. El riesgo de sesgo de selección fue bajo en todos los estudios, mientras que el riesgo de sesgo de detección fue alto en todos excepto en un estudio. Diez estudios se realizaron en pacientes adultos, mientras que dos estudios informaron sobre LCT pediátrica. Un metanálisis para GOS mostró que un NLR alto predijo resultados desfavorables en ≥6 meses con una diferencia media de -5,18 (intervalo de confianza del 95%: -10,04, -0,32); P = 0,04; heterogeneidad (I2), siendo del 98%. Las estimaciones del efecto para NLR y mortalidad fueron una diferencia media de -3,22 (intervalo de confianza del 95%: -7,12, 0,68), P = 0,11, y una I2 del 85%. El metanálisis de las características operativas del receptor del área bajo la curva (AUC) de los estudios incluidos mostró un buen poder predictivo del NLR para predecir los resultados tras una LCT, con un AUC de 0,706 (IC del 95%: 0,582-0,829). Conclusiones: Un NLR al ingreso más alto predice un mayor riesgo de mortalidad y resultados desfavorables después de una LCT. Sin embargo, es probable que futuras investigaciones aborden las lagunas existentes. 2022, Scientific Scholar LLC. Todos los derechos reservados.Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple and routinely performed hematological parameter; however, studies on NLR as a prognostic tool in traumatic brain injury (TBI) have yielded contradictory results. Materials and Methods: This systematic review and meta-analysis was conducted according to the Preferred Reporting Items in the Systematic Review and Meta-Analysis guidelines 2020. Electronic databases of PubMed, Cochrane Library, Web of Science, and Scopus were searched. The population consisted of TBI patients in the absence of moderate and severe extracranial injury. Day 1 NLR was taken for the analysis. The outcomes evaluated were mortality and the Glasgow Outcome Scale (GOS). No restrictions were placed on the language, year and country of publication, and duration of follow-up. Animal studies were excluded from the study. Studies, where inadequate data were reported for the outcomes, were included in the qualitative synthesis but excluded from the quantitative synthesis. Study quality was evaluated using the Newcastle-Ottawa scale (NOS). The risk of bias was estimated using the Cochrane RoBANS risk of bias tool. Results: We retrieved 7213 citations using the search strategy and 2097 citations were excluded based on the screening of the title and abstract. Full text was retrieved for 40 articles and subjected to the eligibility criteria, of which 28 were excluded from the study. Twelve studies were eligible for the synthesis of the systematic review while seven studies qualified for the meta-analysis. The median score of the articles was 8/9 as per NOS. The risk of selection bias was low in all the studies while the risk of detection bias was high in all except one study. Ten studies were conducted on adult patients, while two studies reported pediatric TBI. A meta-analysis for GOS showed that high NLR predicted unfavorable outcomes at ≥6 months with a mean difference of −5.18 (95% confidence interval: −10.04, −0.32); P = 0.04; heterogeneity (I2), being 98%. The effect estimates for NLR and mortality were a mean difference of −3.22 (95% confidence interval: −7.12, 0.68), P = 0.11, and an I2 of 85%. Meta-analysis for Area under the curve (AUC) receiver operating characteristic of the included studies showed good predictive power of NLR in predicting outcomes following TBI with AUC 0.706 (95% CI: 0.582–0.829). Conclusion: A higher admission NLR predicts an increased mortality risk and unfavorable outcomes following TBI. However, future research will likely address the existing gaps. © 2022, Scientific Scholar LLC. All rights reserved

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2). Our study has defined the origin of these macrophages by showing Gr1+ inflammatory monocytes (IMs) are preferentially recruited to pulmonary metastases but not primary mammary tumors, a process also found for human IMs in pulmonary metastases of human breast cancer cells. The recruitment of these CCR2 (receptor for chemokine CCL2) expressing IMs and subsequently MAMs and their interaction with metastasizing tumor cells is dependent on tumor and stromal synthesized CCL2 (FigS1). Inhibition of CCL2/CCR2 signaling using anti-CCL2 antibodies blocks IM recruitment and inhibits metastasis in vivo and prolongs the survival of tumor-bearing mice. Depletion of tumor cell-derived CCL2 also inhibits metastatic seeding. IMs promote tumor cell extravasation in a process that requires monocyte-derived VEGF. CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer (Fig S2)(3-6). Our data provides the mechanistic link between these two clinical associations and indicates new therapeutic targets for treating metastatic breast disease