Chilean Political Documentary Video of the 1980s

The chapter seeks to reconsider Chilean anti-dictatorship video documentary through both historical contextualization and close textual analysis of a series of landmark political video documentaries produced in Chile during that decade. The chapter proposes that these videos are significant components of Chile’s national screen culture’s ongoing engagement with the traumatic memory of the dictatorship period. The videos offer an example of oppositional media at a time when any form of opposition amounted to a defiant and risky gesture. These videos not only documented state violence and political resistance in Chile in the 1980s but constituted a form of resistance in their own right

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

The acute neurotoxicity of oligomeric forms of amyloid-beta 1-42 (Abeta) is implicated in the pathogenesis of Alzheimer's disease (AD). However, how these oligomers might first impair neuronal function at the onset of pathology is poorly understood. Here we have examined the underlying toxic effects caused by an increase in levels of intracellular Abeta, an event that could be important during the early stages of the disease. We show that oligomerised Abeta induces a rapid enhancement of AMPA receptor-mediated synaptic transmission (EPSCA) when applied intracellularly. This effect is dependent on postsynaptic Ca(2+) and PKA. Knockdown of GluA1, but not GluA2, prevents the effect, as does expression of a S845-phosphomutant of GluA1. Significantly, an inhibitor of Ca(2+)-permeable AMPARs (CP-AMPARs), IEM 1460, reverses the increase in the amplitude of EPSCA. These results suggest that a primary neuronal response to intracellular Abeta oligomers is the rapid synaptic insertion of CP-AMPARs