Sexual differentiation of neural circuitry in the neuroendocrine hypothalamus

Estrogen or aromatizable androgen exerts potent influences on modulating neural development and neural circuit formation in developing sex steroid-sensitive neuroendocrine hypothalamus. Sex steroids can act as a neurotrophic factor on neural tissues, stimulating axonal and dendritic growth and synapse formation. Sex steroids are involved in regulation of expression of certain structural proteins and their messenger ribonucleic acids in the hypothalamic neurons, which could affect neuropil organization. These organizational actions of sex steroids seem to induce permanent sexual difference in neuronal circuitry driving neuroendocrine and behavioral functions of the hypothalamus.Biomedical Reviews 1997; 7: 5-15

スマートフォンを用いて近距離からディスプレイとポインティング連携するための不可視ARマーカ

学位の種別: 修士University of Tokyo(東京大学

“Media for Capability” of Children with Disabilities: Development of the Japanese Augmentative Alternative Communication App by Tablet for Persons with Hard of Hearing

Over the past few decades, a considerable number of studies have been conducted on the communication for persons with Hard of hearing and Deaf in Japan. But little attention has been given to the take advantage of Information Technology devices to support the communication for Hard of hearing children. \ \ By the way, the present study analyses in greater detail the survey results summarized in the importance of the “Tablet-Media”. We discuss our communication assist software to express texts and images by Android application for children with Hard of hearing. In this paper, this app is analyzed using the “Capability theory” with emphasis on the power of self-expression and the right to self-determination of persons with disabilities. \ \ The results of our performance tests showed that our system was very helpful in order to provide their “Capability” for Hard of hearing children. We suggest the potential to combine our App is what we should call “Media for Capability” of communication in children with hard of hearing

Recruitment of DNA repair synthesis machinery to sites of DNA damage/repair in living human cells

The eukaryotic sliding DNA clamp, proliferating cell nuclear antigen (PCNA), is essential for DNA replication and repair synthesis. In order to load the ring-shaped, homotrimeric PCNA onto the DNA double helix, the ATPase activity of the replication factor C (RFC) clamp loader complex is required. Although the recruitment of PCNA by RFC to DNA replication sites has well been documented, our understanding of its recruitment during DNA repair synthesis is limited. In this study, we analyzed the accumulation of endogenous and fluorescent-tagged proteins for DNA repair synthesis at the sites of DNA damage produced locally by UVA-laser micro-irradiation in HeLa cells. Accumulation kinetics and in vitro pull-down assays of the large subunit of RFC (RFC140) revealed that there are two distinct modes of recruitment of RFC to DNA damage, a simultaneous accumulation of RFC140 and PCNA caused by interaction between PCNA and the extreme N-terminus of RFC140 and a much faster accumulation of RFC140 than PCNA at the damaged site. Furthermore, RFC140 knock-down experiments showed that PCNA can accumulate at DNA damage independently of RFC. These results suggest that immediate accumulation of RFC and PCNA at DNA damage is only partly interdependent

Calculating composite-particle spectra in Hamiltonian formalism and demonstration in 2-flavor QED1+1d_{1+1\text{d}}

We consider three distinct methods to compute the mass spectrum of gauge theories in the Hamiltonian formalism: (1) correlation-function scheme, (2) one-point-function scheme, and (3) dispersion-relation scheme. The first one corresponds to the conventional Euclidean method in the Monte Carlo simulations. The second one uses the boundary effect to efficiently compute the mass spectrum. The third one constructs the excited states and fits their energy using the dispersion relation with selecting quantum numbers. Each method has its pros and cons, and we clarify such properties in their applications to the mass spectrum for the 2-flavor massive Schwinger model at $m/g=0.1$ and $\theta=0$ using the density-matrix renormalization group (DMRG). We note that the multi-flavor Schwinger model at small mass $m$ is a strongly-coupled field theory even after the bosonizations, and thus it deserves to perform the first-principles numerical calculations. All these methods mostly agree and identify the stable particles, pions $\pi_a$ ($J^{PG}=1^{-+}$), sigma meson $\sigma$ ($J^{PG}=0^{++}$), and eta meson $\eta$ ($J^{PG}=0^{--}$). In particular, we find that the mass of $\sigma$ meson is lighter than twice the pion mass, and thus $\sigma$ is stable against the decay process, $\sigma \to \pi\pi$. This is consistent with the analytic prediction using the WKB approximation, and, remarkably, our numerical results are so close to the WKB-based formula between the pion and sigma-meson masses, $M_\sigma/M_\pi=\sqrt{3}$.Comment: 40 pages, 16 figure