1,203 research outputs found
A VLBA survey of the core shift effect in AGN jets I. Evidence for dominating synchrotron opacity
The effect of a frequency dependent shift of the VLBI core position (known as
the "core shift") was predicted more than three decades ago and has since been
observed in a few sources, but often within a narrow frequency range. This
effect has important astrophysical and astrometric applications. To achieve a
broader understanding of the core shift effect and the physics behind it, we
conducted a dedicated survey with NRAO's Very Long Baseline Array (VLBA). We
used the VLBA to image 20 pre-selected sources simultaneously at nine
frequencies in the 1.4-15.4 GHz range. The core position at each frequency was
measured by referencing it to a bright, optically thin feature in the jet. A
significant core shift has been successfully measured in each of the twenty
sources observed. The median value of the core shift is found to be 1.21 mas if
measured between 1.4 and 15.4 GHz, and 0.24 mas between 5.0 and 15.4 GHz. The
core position, r, as a function of frequency, n, is found to be consistent with
an r n^-1 law. This behavior is predicted by the Blandford & Koenigl model of a
purely synchrotron self-absorbed conical jet in equipartition. No systematic
deviation from unity of the power law index in the r(n) relation has been
convincingly detected. We conclude that neither free-free absorption nor
gradients in pressure and/or density in the jet itself and in the ambient
medium surrounding the jet play a significant role in the sources observed
within the 1.4-15.4 GHz frequency range. These results support the
interpretation of the parsec-scale core as a continuous Blandford-Koenigl type
jet with smooth gradients of physical properties along it.Comment: 31 pages, 6 figures, 5 tables; accepted to Astronomy & Astrophysic
Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.
Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity. The recruitment of innate leukocytes has been well studied in the context of extracellular bacterial and fungal infection but less during viral infections. We have recently shown that the understudied cytokine Interleukin (IL)-17D can mediate neutrophil, natural killer (NK) cell and monocyte infiltration in sterile inflammation and cancer. Herein, we show that early immune cell accumulation at the peritoneal site of infection by mouse cytomegalovirus (MCMV) is mediated by IL-17D. Mice deficient in IL-17D or the transcription factor Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an inducer of IL-17D, featured an early decreased number of innate immune cells at the point of viral entry and were more susceptible to MCMV infection. Interestingly, we were able to artificially induce innate leukocyte infiltration by applying the Nrf2 activator tert-butylhydroquinone (tBHQ), which rendered mice less susceptible to MCMV infection. Our results implicate the Nrf2/IL-17D axis as a sensor of viral infection and suggest therapeutic benefit in boosting this pathway to promote innate antiviral responses
Grey matter volume alterations in CADASIL: a voxel-based morphometry study
CADASIL is a hereditary disease characterized by cerebral subcortical microangiopathy leading to early onset cerebral strokes and progressive severe cognitive impairment. Until now, only few studies have investigated the extent and localization of grey matter (GM) involvement. The purpose of our study was to evaluate GM volume alterations in CADASIL patients compared to healthy subjects. We also looked for correlations between global and regional white matter (WM) lesion load and GM volume alterations. 14 genetically proved CADASIL patients and 12 healthy subjects were enrolled in our study. Brain MRI (1.5 T) was acquired in all subjects. Optimized-voxel based morphometry method was applied for the comparison of brain volumes between CADASIL patients and controls. Global and lobar WM lesion loads were calculated for each patient and used as covariate-of-interest for regression analyses with SPM-8. Compared to controls, patients showed GM volume reductions in bilateral temporal lobes (p < 0.05; FDR-corrected). Regression analysis in the patient group revealed a correlation between total WM lesion load and temporal GM atrophy (p < 0.05; uncorrected), not between temporal lesion load and GM atrophy. Temporal GM volume reduction was demonstrated in CADASIL patients compared to controls; it was related to WM lesion load involving the whole brain but not to lobar and, specifically, temporal WM lesion load. Complex interactions between sub-cortical and cortical damage should be hypothesized
Differential adherence and expression of virulence traits by Candida albicans and Candida parapsilosis in mono- and dual-species cultures in artificial saliva
AIMS:
To evaluate specific virulence factors of Candida albicans and Candida parapsilosis clinical oral isolates in mono- and dual-species culture in the presence of artificial saliva.
METHODS AND RESULTS:
Two of the strains used in this study were isolated from co-infection (C. albicans AM and C. parapsilosis AM2), and the other two were isolated from single infection (C. albicans AC and C. parapsilosis AD). The number of adhered yeast cells was measured and their enzymatic activity was determined simultaneously. In mono-species culture, C. parapsilosis strains adhered to a higher extent to the surface in comparison with the C. albicans strains. In dual-species culture, the C. parapsilosis strains adhered more in the presence of C. albicans AM. Interestingly, C. albicans AM and C. parapsilosis AD adhered to a higher extent when compared with all other co-cultures. In dual-species culture, the enzymatic activity of C. parapsilosis strains in the presence of C. albicans AC was higher than in the presence of C. albicans AM.
CONCLUSIONS:
The virulence factors of C. albicans and C. parapsilosis differ from strain to strain and are influenced by the presence of other species in culture.
SIGNIFICANCE AND IMPACT OF THE STUDY:
To understand the expression of virulence factors in Candida dual-species systems.This work was supported by Portuguese Foundation for Science and Technology (FCT) through the grant SFRH/BPD/20987/2004 attributed to Claudia Botelho
The XMM Cluster Survey: The interplay between the brightest cluster galaxy and the intra-cluster medium via AGN feedback
Using a sample of 123 X-ray clusters and groups drawn from the XMM-Cluster
Survey first data release, we investigate the interplay between the brightest
cluster galaxy (BCG), its black hole, and the intra-cluster/group medium (ICM).
It appears that for groups and clusters with a BCG likely to host significant
AGN feedback, gas cooling dominates in those with Tx > 2 keV while AGN feedback
dominates below. This may be understood through the sub-unity exponent found in
the scaling relation we derive between the BCG mass and cluster mass over the
halo mass range 10^13 < M500 < 10^15Msol and the lack of correlation between
radio luminosity and cluster mass, such that BCG AGN in groups can have
relatively more energetic influence on the ICM. The Lx - Tx relation for
systems with the most massive BCGs, or those with BCGs co-located with the peak
of the ICM emission, is steeper than that for those with the least massive and
most offset, which instead follows self-similarity. This is evidence that a
combination of central gas cooling and powerful, well fuelled AGN causes the
departure of the ICM from pure gravitational heating, with the steepened
relation crossing self-similarity at Tx = 2 keV. Importantly, regardless of
their black hole mass, BCGs are more likely to host radio-loud AGN if they are
in a massive cluster (Tx > 2 keV) and again co-located with an effective fuel
supply of dense, cooling gas. This demonstrates that the most massive black
holes appear to know more about their host cluster than they do about their
host galaxy. The results lead us to propose a physically motivated, empirical
definition of 'cluster' and 'group', delineated at 2 keV.Comment: Accepted for publication in MNRAS - replaced to match corrected proo
The evolution of tooth wear indices
Tooth wear—attrition, erosion and abrasion—is perceived internationally as an ever-increasing problem. Clinical and epidemiological studies, however, are difficult to interpret and compare due to differences in terminology and the large number of indices that have been developed for diagnosing, grading and monitoring dental hard tissue loss. These indices have been designed to identify increasing severity and are usually numerical. Some record lesions on an aetiological basis (e.g. erosion indices), others record lesions irrespective of aetiology (tooth wear indices); none have universal acceptance, complicating the evaluation of the true increase in prevalence reported. This article considers the ideal requirements for an erosion index. It reviews the literature to consider how current indices have evolved and discusses if these indices meet the clinical and research needs of the dental profession
Constructing Memories of Holmfirth through 'Last of the Summer Wine'
Last of the Summer Wine (BBC, 1973-2010) was filmed in Holmfirth, West Yorkshire, UK for 37 years. Its presence in the town has affected collective memories of the space and place of the region. In examining Summer Wine’s continued presence in Holmfirth even after it has ceased production, we investigate how the series as a text, institution and brand serves to spatially inform Holmfirth and construct, embed and inform cultural memory
CMB Telescopes and Optical Systems
The cosmic microwave background radiation (CMB) is now firmly established as
a fundamental and essential probe of the geometry, constituents, and birth of
the Universe. The CMB is a potent observable because it can be measured with
precision and accuracy. Just as importantly, theoretical models of the Universe
can predict the characteristics of the CMB to high accuracy, and those
predictions can be directly compared to observations. There are multiple
aspects associated with making a precise measurement. In this review, we focus
on optical components for the instrumentation used to measure the CMB
polarization and temperature anisotropy. We begin with an overview of general
considerations for CMB observations and discuss common concepts used in the
community. We next consider a variety of alternatives available for a designer
of a CMB telescope. Our discussion is guided by the ground and balloon-based
instruments that have been implemented over the years. In the same vein, we
compare the arc-minute resolution Atacama Cosmology Telescope (ACT) and the
South Pole Telescope (SPT). CMB interferometers are presented briefly. We
conclude with a comparison of the four CMB satellites, Relikt, COBE, WMAP, and
Planck, to demonstrate a remarkable evolution in design, sensitivity,
resolution, and complexity over the past thirty years.Comment: To appear in: Planets, Stars and Stellar Systems (PSSS), Volume 1:
Telescopes and Instrumentatio
Interviews with Irish healthcare workers from different disciplines about palliative care for people with Parkinson’s disease: a definite role but uncertainty around terminology and timing
Background: An integrated palliative care approach is recommended in all life-limiting diseases, including Parkinson’s disease (PD). However research shows that people with PD have unmet palliative care needs. The study aimed to explore multidisciplinary healthcare workers’ (HCWs) views on palliative care for people with PD, identifying perceived barriers and facilitators. Methods: A qualitative design was used; data was analysed using Thematic Analysis. Semi-structured interviews were conducted with 30 HCWs, working either with people with PD or in a palliative care setting in Ireland. Results: A number of perceived barriers were evident helping to account for the previously reported unmet palliative care needs in PD. A lack of education about PD and palliative care meant that HCWs were unsure of the appropriateness of referral, and patients and carers weren’t equipped with information to seek palliative care. A lack of communication between PD and palliative care specialists was seen to impede collaboration between the disciplines. Uncertainty about the timing of palliative care meant that it was often not introduced until a crisis point, despite the recognised need for early planning due to increased prevalence of dementia. Conclusions: Most HCWs recognised a need for palliative care for people with PD; however several barriers to implementing a palliative care approach in this population need to be addressed. Implications for clinical practice and policy include the need for an integrated model of care, and education for all HCWs, patients, carers, and the public on both the nature of advanced PD, and the potential of palliative care in support of patients and their family members
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