Scale-specific spatial density-dependence in parasitoids: a multi-factor meta-analysis

1. Within a landscape, the risk of an insect being attacked by a parasitoid varies with the local density of the host species. This relationship should be strongest when observed at medium extents and resolutions with respect to the parasitoids’ foraging range, and turn negative at fine resolutions. The relationship is also hypothesised to depend on certain traits of the host and parasitoid taxa – e.g. being more positive for more specialised hosts or parasitoids and more negative for mobile hosts or gregarious parasitoids. Building on earlier literature reviews, it is now possible to investigate these hypotheses using meta-analysis. 2. We performed a multi-factor meta-analysis on 151 analyses of parasitism rates with respect to host densities at specified scales, from 61 empirical studies published from 1988 to 2012. We explored how the correlation between host density and parasitism rate may be related to the explanatory variables already mentioned, plus parasitoid body-size and various other characteristics of both hosts and parasitoids. 3. Correlations (Pearson’s r) between host density and parasitism rate ranged from –0.88 to 0.98 (mean 0.16, standard deviation 0.39). The correlation was more often negative where the host was exotic or in the orders Lepidoptera or Diptera, where the parasitoid was larger or exotic, or where the study was conducted at a finer grain-size. Hymenoptera and Homoptera were the most likely host orders to reveal positive associations, with Coleoptera and Diptera intermediate. 4. The fact that increased observational grain-size had similar effects to decreased parasitoid body length could be taken as evidence that parasitoids’ foraging ranges increase with their body-length. However, the hypothesis about scale-specific foraging was not supported by studies that compared multiple scales. 5. We conclude that parasitism most commonly produces positive (compensatory) spatial density-dependence, but ecological context is all-important. These findings should help improve the design and interpretation of field experiments on parasitism as well as their application to the modelling of population dynamics and the practice of biological control

Homophily and Contagion Are Generically Confounded in Observational Social Network Studies

We consider processes on social networks that can potentially involve three factors: homophily, or the formation of social ties due to matching individual traits; social contagion, also known as social influence; and the causal effect of an individual's covariates on their behavior or other measurable responses. We show that, generically, all of these are confounded with each other. Distinguishing them from one another requires strong assumptions on the parametrization of the social process or on the adequacy of the covariates used (or both). In particular we demonstrate, with simple examples, that asymmetries in regression coefficients cannot identify causal effects, and that very simple models of imitation (a form of social contagion) can produce substantial correlations between an individual's enduring traits and their choices, even when there is no intrinsic affinity between them. We also suggest some possible constructive responses to these results.Comment: 27 pages, 9 figures. V2: Revised in response to referees. V3: Ditt

Cosmological parameters from SDSS and WMAP

We measure cosmological parameters using the three-dimensional power spectrum P(k) from over 200,000 galaxies in the Sloan Digital Sky Survey (SDSS) in combination with WMAP and other data. Our results are consistent with a ``vanilla'' flat adiabatic Lambda-CDM model without tilt (n=1), running tilt, tensor modes or massive neutrinos. Adding SDSS information more than halves the WMAP-only error bars on some parameters, tightening 1 sigma constraints on the Hubble parameter from h~0.74+0.18-0.07 to h~0.70+0.04-0.03, on the matter density from Omega_m~0.25+/-0.10 to Omega_m~0.30+/-0.04 (1 sigma) and on neutrino masses from <11 eV to <0.6 eV (95%). SDSS helps even more when dropping prior assumptions about curvature, neutrinos, tensor modes and the equation of state. Our results are in substantial agreement with the joint analysis of WMAP and the 2dF Galaxy Redshift Survey, which is an impressive consistency check with independent redshift survey data and analysis techniques. In this paper, we place particular emphasis on clarifying the physical origin of the constraints, i.e., what we do and do not know when using different data sets and prior assumptions. For instance, dropping the assumption that space is perfectly flat, the WMAP-only constraint on the measured age of the Universe tightens from t0~16.3+2.3-1.8 Gyr to t0~14.1+1.0-0.9 Gyr by adding SDSS and SN Ia data. Including tensors, running tilt, neutrino mass and equation of state in the list of free parameters, many constraints are still quite weak, but future cosmological measurements from SDSS and other sources should allow these to be substantially tightened.Comment: Minor revisions to match accepted PRD version. SDSS data and ppt figures available at http://www.hep.upenn.edu/~max/sdsspars.htm

Governing Boards and Profound Organizational Change in Hospitals

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69047/2/10.1177_107755878904600204.pd

The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s

Visualization and analysis of frames in collections of messages: Content analysis and the measurement of meaning.

A step-by-step introduction is provided on how to generate a semantic map from a collection of messages (full texts, paragraphs, or statements) using freely available software and/or SPSS for the relevant statistics and the visualization. The techniques are discussed in the various theoretical contexts of (i) linguistics (e.g., Latent Semantic Analysis), (ii) sociocybernetics and social systems theory (e.g., the communication of meaning), and (iii) communication studies (e.g., framing and agenda-setting). The authors distinguish between the communication of information in the network space (social network analysis) and the communication of meaning in the vector space. The vector space can be considered a generated as an architecture by the network of relations in the network space; words are then not only related, but also positioned. These positions are expected rather than observed, and therefore one can communicate meaning. Knowledge can be generated when these meanings can recursively be communicated and therefore also further codified

A role for mammalian Ubc6 homologues in ER-associated protein degradation

Integral membrane and secretory proteins which fail to fold productively are retained in the endoplasmic reticulum and targeted for degradation by cytoplasmic proteasomes. Genetic and biochemical analyses suggest that substrates of this pathway must be dislocated across the membrane of the endoplasmic reticulum (ER) by a process requiring a functional Sec61 complex and multiubiquitinylation. In yeast, the tail-anchored ubiquitin-conjugating enzyme Ubc6p, which is localized to the cytoplasmic surface of the ER, participates in ER-associated degradation (ERAD) of misfolded proteins. Here we describe the identification of two families of mammalian Ubc6p-related proteins. Members of both families are also located in the ER membrane and display a similar membrane topology as the yeast enzyme. Furthermore we show that expression of elevated levels of wild-type and dominant-negative alleles of these components affects specifically ERAD of the α subunit of the T-cell receptor and a mutant form of the CFTR protein. Similarly, we describe that the expression level of Ubc6p in yeast is also critical for ERAD, suggesting that the Ubc6p function is highly conserved from yeast to mammals